ES2637024T3 - Composición farmacéutica para el tratamiento de enfermedades inflamatorias mediadas por MCP-1 - Google Patents

Composición farmacéutica para el tratamiento de enfermedades inflamatorias mediadas por MCP-1 Download PDF

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ES2637024T3
ES2637024T3 ES10747897.6T ES10747897T ES2637024T3 ES 2637024 T3 ES2637024 T3 ES 2637024T3 ES 10747897 T ES10747897 T ES 10747897T ES 2637024 T3 ES2637024 T3 ES 2637024T3
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captopril
group
pharmaceutical composition
arb
pharmaceutically acceptable
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Angelo Guglielmotti
Beatrice Garrone
Alessandro Ble'
Giuseppe Biondi
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Angelini Acraf SpA
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Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Composición farmacéutica, que comprende: (a) el ácido 2-((1-bencil-3-indazolil)metoxi)-2-metilpropiónico que presenta la fórmula estructural siguiente: (b) por lo menos uno de entre (i) un agente hipotensor seleccionado de entre unos inhibidores de ACE, ARB y CCB, y/o (ii) un agente reductor del colesterol seleccionado de entre unos derivados de estatina, o cualquier sal farmacéuticamente aceptable y éster del mismo, y (c) por lo menos un vehículo farmacéuticamente aceptable, en la que dicho inhibidor de ACE se selecciona de entre el grupo que consiste en alacepril, altiopril calcio, benzoil-captopril, captopril, captopril-cisteína, captopril-glutatión, ceronapril, converstatina, enalapril, enalaprilato, epicaptopril, fosinopril, fosinopril sodio, fosinoprilato, hemorfina-4, indolapril, indolaprilato, lisinopril, moveltipril, pentopril, perindopril, perindoprilato, quinapril, clorhidrato de quinapril, quinaprilato, ramipril, ramiprilato, espirapril, clorhidrato de espirapril, espiraprilato, trandolapril, trandolaprilato, zabicipril, zabiciprilato, zofenopril, zofenoprilato, dicho ARB se selecciona de entre el grupo que consiste en candesartán, cilexetilo, irbesartán, losartán, olmesartán, telmisartán, valsartán y pratosartán, dicho CCB se selecciona de entre el grupo que consiste en amlodipino, aranidipino, barnidipino, benidipino, cilnidipino, efonidipino, elgodipino, felodipino, isradipino, lacidipino, lercanidipino, manidipino, nicardipino, nifedipino, nilvadipino, nimodipino, nisoldipino, nitrendipino, diltiazem, clentiazem, bepridilo, benciclano, etafenona, flunarizina, lidoflazina, lomerizina, mibefradilo, fendilina, prenilamina, semotiadilo, terodilina, galopamilo y verapamilo, dicho derivado de estatina se selecciona de entre el grupo que consiste en lovastatina, mevastatina, pravastatina y simvastatina.

Description

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Claims (1)

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ES10747897.6T 2009-09-23 2010-09-03 Composición farmacéutica para el tratamiento de enfermedades inflamatorias mediadas por MCP-1 Active ES2637024T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09425368 2009-09-23
EP09425368 2009-09-23
PCT/EP2010/062979 WO2011036047A1 (en) 2009-09-23 2010-09-03 Pharmaceutical composition for the treatment of mcp-1 mediated inflammatory diseases

Publications (1)

Publication Number Publication Date
ES2637024T3 true ES2637024T3 (es) 2017-10-10

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ES10747897.6T Active ES2637024T3 (es) 2009-09-23 2010-09-03 Composición farmacéutica para el tratamiento de enfermedades inflamatorias mediadas por MCP-1

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Country Link
US (1) US9492542B2 (es)
EP (1) EP2480224B1 (es)
JP (2) JP2013505278A (es)
KR (1) KR101774402B1 (es)
CN (1) CN102573827B (es)
AR (1) AR078307A1 (es)
AU (1) AU2010297405B2 (es)
BR (1) BR112012006149A2 (es)
CA (1) CA2760180C (es)
CY (1) CY1119125T1 (es)
DK (1) DK2480224T3 (es)
EA (1) EA021485B1 (es)
ES (1) ES2637024T3 (es)
GE (1) GEP20146067B (es)
HR (1) HRP20171209T1 (es)
HU (1) HUE033102T2 (es)
IL (1) IL218001A (es)
LT (1) LT2480224T (es)
MX (1) MX347957B (es)
PL (1) PL2480224T3 (es)
PT (1) PT2480224T (es)
SG (2) SG178414A1 (es)
SI (1) SI2480224T1 (es)
SM (1) SMT201700330T1 (es)
UA (1) UA108742C2 (es)
WO (1) WO2011036047A1 (es)

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Publication number Publication date
CN102573827B (zh) 2016-08-31
JP2013505278A (ja) 2013-02-14
CA2760180A1 (en) 2011-03-31
EP2480224A1 (en) 2012-08-01
MX347957B (es) 2017-05-16
AU2010297405B2 (en) 2016-05-26
EA021485B1 (ru) 2015-06-30
DK2480224T3 (en) 2017-09-04
PT2480224T (pt) 2017-07-18
LT2480224T (lt) 2017-08-25
CA2760180C (en) 2017-07-25
MX2012003485A (es) 2012-04-19
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US9492542B2 (en) 2016-11-15
JP2016028026A (ja) 2016-02-25
PL2480224T3 (pl) 2017-10-31
IL218001A0 (en) 2012-04-30
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CN102573827A (zh) 2012-07-11
EA201270449A1 (ru) 2012-08-30
UA108742C2 (uk) 2015-06-10
EP2480224B1 (en) 2017-05-24
WO2011036047A1 (en) 2011-03-31
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KR20120090988A (ko) 2012-08-17
AU2010297405A1 (en) 2012-03-01
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SI2480224T1 (sl) 2017-10-30
CY1119125T1 (el) 2018-02-14
JP6122470B2 (ja) 2017-04-26
BR112012006149A2 (pt) 2016-06-28
US20120220636A1 (en) 2012-08-30
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IL218001A (en) 2015-10-29

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