ES2640012T3 - Nanoparticulas de dioxido de silicio y el uso de las mismas para la vacunacion - Google Patents

Nanoparticulas de dioxido de silicio y el uso de las mismas para la vacunacion Download PDF

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Publication number
ES2640012T3
ES2640012T3 ES09777154.7T ES09777154T ES2640012T3 ES 2640012 T3 ES2640012 T3 ES 2640012T3 ES 09777154 T ES09777154 T ES 09777154T ES 2640012 T3 ES2640012 T3 ES 2640012T3
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silicon dioxide
antigen
nanoparticles
vaccination
vaccine
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Markus Weigandt
Andrea Hanefeld
Armin Kuebelbeck
Gregor Larbig
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Merck Patent GmbH
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Merck Patent GmbH
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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Abstract

Nanopartículas monodispersas que comprenden una matriz de más de 50% de dióxido de silicio que presentan en su superficie uno o más grupos químicos como conectores para fijar y liberar de manera controlada un antígeno, y al menos un antígeno se enlaza de modo específico al sitio y de modo covalente al conector, y las partículas tienen un tamaño de 5 a 50 nm, del cual la desviación estándar es de máximo 15% para el uso como vacuna para la fijación como objetivo de antígenos en células que presentan antígeno, para activar el sistema inmune y como adyuvante.

Description

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Claims (1)

  1. imagen1
ES09777154.7T 2008-07-15 2009-07-13 Nanoparticulas de dioxido de silicio y el uso de las mismas para la vacunacion Active ES2640012T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008033175 2008-07-15
DE102008033175A DE102008033175A1 (de) 2008-07-15 2008-07-15 Siliciumdioxid-Nanopartikel und deren Verwendung zur Vakzinierung
PCT/EP2009/005078 WO2010006753A2 (de) 2008-07-15 2009-07-13 Siliciumdioxid-nanopartikel und deren verwendung zur vakzinierung

Publications (1)

Publication Number Publication Date
ES2640012T3 true ES2640012T3 (es) 2017-10-31

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ES09777154.7T Active ES2640012T3 (es) 2008-07-15 2009-07-13 Nanoparticulas de dioxido de silicio y el uso de las mismas para la vacunacion
ES17175233T Active ES2885055T3 (es) 2008-07-15 2009-07-13 Nanoparticulas de dioxido de silicio y el uso de las mismas para la vacunacion

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES17175233T Active ES2885055T3 (es) 2008-07-15 2009-07-13 Nanoparticulas de dioxido de silicio y el uso de las mismas para la vacunacion

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US (4) US8980324B2 (es)
EP (2) EP3241545B1 (es)
JP (3) JP5726075B2 (es)
KR (2) KR101694130B1 (es)
CN (2) CN105126115B (es)
AU (1) AU2009270468B2 (es)
BR (2) BRPI0915788B8 (es)
CA (1) CA2730694C (es)
DE (1) DE102008033175A1 (es)
DK (2) DK3241545T3 (es)
EA (1) EA023047B1 (es)
ES (2) ES2640012T3 (es)
HU (2) HUE036309T2 (es)
MX (1) MX341881B (es)
PT (2) PT3241545T (es)
WO (1) WO2010006753A2 (es)
ZA (1) ZA201101171B (es)

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