ES2694667T3 - Método para producir oxalato oxidasas que tienen actividad óptica cerca de pH fisiológico y uso de tales oxalato oxidasas recombinantes en el tratamiento de enfermedades relacionadas con oxalato - Google Patents
Método para producir oxalato oxidasas que tienen actividad óptica cerca de pH fisiológico y uso de tales oxalato oxidasas recombinantes en el tratamiento de enfermedades relacionadas con oxalato Download PDFInfo
- Publication number
- ES2694667T3 ES2694667T3 ES14819001.0T ES14819001T ES2694667T3 ES 2694667 T3 ES2694667 T3 ES 2694667T3 ES 14819001 T ES14819001 T ES 14819001T ES 2694667 T3 ES2694667 T3 ES 2694667T3
- Authority
- ES
- Spain
- Prior art keywords
- oxalate
- oxidases
- recombinant
- treatment
- related diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108010063734 Oxalate oxidase Proteins 0.000 title abstract 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000003287 optical effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
- C12Y102/03004—Oxalate oxidase (1.2.3.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Oxalato oxidasa recombinante que tiene una identidad de secuencia de al menos el 60% con los polipéptidos de SEQ ID NO: 2, SEQ ID NO: 4 o SEQ ID NO: 6, o una identidad de secuencia de al menos el 99% con el polipéptido de SEQ ID NO: 8, y en la que la oxalato oxidasa recombinante puede degradar oxalato con una actividad relativa de al menos el 20% a pH 7,5, en la que se calcula la actividad relativa como (actividad observada (pH 7,5)/actividad máx.) * 100%.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199309 | 2013-12-23 | ||
| EP13199309 | 2013-12-23 | ||
| PCT/EP2014/078984 WO2015097148A1 (en) | 2013-12-23 | 2014-12-22 | Method for producing oxalate oxidases having activity optimum near physiological ph and use of such recombinant oxalate oxidases in the treatment of oxalate-related diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2694667T3 true ES2694667T3 (es) | 2018-12-26 |
Family
ID=49885050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14819001.0T Active ES2694667T3 (es) | 2013-12-23 | 2014-12-22 | Método para producir oxalato oxidasas que tienen actividad óptica cerca de pH fisiológico y uso de tales oxalato oxidasas recombinantes en el tratamiento de enfermedades relacionadas con oxalato |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10266811B2 (es) |
| EP (1) | EP3087178B1 (es) |
| DK (1) | DK3087178T3 (es) |
| ES (1) | ES2694667T3 (es) |
| PL (1) | PL3087178T3 (es) |
| PT (1) | PT3087178T (es) |
| WO (1) | WO2015097148A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6820246B2 (ja) * | 2017-11-30 | 2021-01-27 | 佳人 鳥居 | 免疫活性化剤の製造方法および免疫活性化用飲食品の製造方法 |
| CN108935101B (zh) * | 2018-08-13 | 2022-06-07 | 云南省农业科学院花卉研究所 | 一种降低彩纹秋海棠叶片组织培养褐化率的方法 |
| CN109793839A (zh) * | 2019-03-13 | 2019-05-24 | 浙江理工大学 | 用于治疗白色念珠菌的三叶青妇科泡腾片及其制备方法 |
| CN110432151B (zh) * | 2019-09-11 | 2022-03-25 | 安徽农业大学 | 一种重阳木的组培快繁方法 |
| CN110933969A (zh) * | 2019-11-08 | 2020-03-31 | 广西南亚热带农业科学研究所 | 一种提高赤苍藤种子发芽率的方法 |
| CN113116764A (zh) * | 2019-12-30 | 2021-07-16 | 四川金铃子生物科技有限公司 | 一种含笑花护肤用品及其制备方法 |
| WO2021183818A1 (en) * | 2020-03-12 | 2021-09-16 | University Of Florida Research Foundation, Incorporated | Recombinant oxalate oxidase and uses thereof |
| CN111568935B (zh) * | 2020-05-25 | 2022-03-25 | 广西中医药大学 | 赤苍藤提取物在制备抗肿瘤药物中的应用 |
| CN111763683B (zh) * | 2020-06-30 | 2022-06-03 | 南京林业大学 | 一种柳杉CfICE1基因及其应用 |
| CN112359051B (zh) * | 2020-11-10 | 2023-07-18 | 杭州鑫旺途科技有限公司 | 一种来源于三叶青的苯丙氨酸解氨酶基因ThPAL及其应用 |
| CN112772416B (zh) * | 2021-01-28 | 2022-08-12 | 苏州金铁红林业科技有限公司 | 一种小叶桢楠的组织培养育苗方法 |
| CN116171863B (zh) * | 2023-03-17 | 2024-02-06 | 江苏省中国科学院植物研究所 | 一种蝴蝶花高效再生的方法 |
| CN117530941B (zh) * | 2023-10-18 | 2024-07-19 | 贵州省畜牧兽医研究所 | 3-(4-甲苯氧基)-丙酸在抑菌方面的应用 |
| CN117502228A (zh) * | 2023-10-19 | 2024-02-06 | 南京林业大学 | 一种白木香组织培养快繁体系的建立方法 |
| CN118615354B (zh) * | 2024-06-19 | 2025-07-11 | 成都中医药大学 | 香橼或其提取物在制备治疗溃疡性结肠炎的药物中的用途，以及一种治疗溃疡性结肠炎的药物组合物 |
| CN119547730A (zh) * | 2024-12-31 | 2025-03-04 | 绍兴市农业科学研究院 | 一种诱导铁筷子快速无性繁殖体系建立的方法 |
| CN120519626B (zh) * | 2025-07-24 | 2025-10-10 | 湖北大学 | 一种鉴定云南金钱槭种群的InDel分子标记与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4455371A (en) * | 1982-03-03 | 1984-06-19 | The Ohio State University Research Foundation | Oxalate oxidase composition for assay of oxalate |
| JP5199077B2 (ja) * | 2005-06-10 | 2013-05-15 | アルタス ファーマシューティカルズ インコーポレイテッド | シュウ酸オキシダーゼ結晶の投与による、シュウ酸塩濃度を低下させるための方法 |
| PT1962873E (pt) | 2005-12-14 | 2013-08-29 | Oxthera Inc | Composições farmacêuticas compreendendo bactérias redutoras de oxalato |
| EP2504428A4 (en) | 2009-11-25 | 2013-09-25 | Captozyme Llc | METHODS AND COMPOSITIONS FOR TREATING OXALATE RELATED DISEASES |
| US20110191903A1 (en) | 2009-12-31 | 2011-08-04 | Pioneer Hi-Bred International, Inc. | Engineering plant resistance to diseases caused by pathogens |
-
2014
- 2014-12-22 US US15/106,914 patent/US10266811B2/en not_active Expired - Fee Related
- 2014-12-22 EP EP14819001.0A patent/EP3087178B1/en not_active Not-in-force
- 2014-12-22 PT PT14819001T patent/PT3087178T/pt unknown
- 2014-12-22 ES ES14819001.0T patent/ES2694667T3/es active Active
- 2014-12-22 DK DK14819001.0T patent/DK3087178T3/en active
- 2014-12-22 WO PCT/EP2014/078984 patent/WO2015097148A1/en not_active Ceased
- 2014-12-22 PL PL14819001T patent/PL3087178T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3087178A1 (en) | 2016-11-02 |
| US10266811B2 (en) | 2019-04-23 |
| PT3087178T (pt) | 2018-11-21 |
| PL3087178T3 (pl) | 2019-03-29 |
| EP3087178B1 (en) | 2018-08-08 |
| WO2015097148A1 (en) | 2015-07-02 |
| DK3087178T3 (en) | 2018-11-26 |
| US20170037383A1 (en) | 2017-02-09 |
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