ES269655A1 - Novel sulphonamides and a process for the manufacture thereof - Google Patents

Novel sulphonamides and a process for the manufacture thereof

Info

Publication number
ES269655A1
ES269655A1 ES0269655A ES269655A ES269655A1 ES 269655 A1 ES269655 A1 ES 269655A1 ES 0269655 A ES0269655 A ES 0269655A ES 269655 A ES269655 A ES 269655A ES 269655 A1 ES269655 A1 ES 269655A1
Authority
ES
Spain
Prior art keywords
alkenyloxy
alkoxy
pyrimidines
halo
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0269655A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH899460A external-priority patent/CH403771A/en
Priority claimed from CH326761A external-priority patent/CH405322A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES269655A1 publication Critical patent/ES269655A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention comprises sulphonilamides of the formula: <FORM:0946485/C2/1> wherein R1 and R2 are lower alkoxy or alkenyloxy groups (the word "lower", indicating a group of 1-6 carbon atoms), pharmaceutically acceptable salts and N4 acyl derivatives of these compounds, the 4-sulphanilamido - 5 - (lower alkoxy) - 6 -halo - pyrimidines and the 4(N4-acylsulphanilamido) - 5 - (lower alkoxy) - 6 - halo - pyrimidines and the 4(N4-acylsulphanilamide) - 5 - (lower alkoxy) - 6 - halo - pyrimidines and comprises also processes for the preparation of these compounds by either condensing a 4-halo-5-alkoxy (or alkenyloxy)-pyrimidine bearing a further halogen, alkoxy or alkenyloxy substituent in the 6-position with a benzenesulphonamide having an amino group or a group convertible to amine by reduction or hydrolysis (e.g. acetamino, ethoxycarbonylamino, nitro, nitroso or azo) in the p-position, if necessary replacing any halogen substituent present on the product by an alkoxy or alkenyloxy group, by heating with an alkali-metal alcoholate, and reducing or hydrolysing to convert any p-substituent into an amino group or condensing a 4-amino-5,6-dialkoxy (or alkenyloxy)-pyrimidine with a benzenesulphonyl halide containing a p-substituent convertible into amino by reduction or hydrolysis, and subsequently effecting the conversion of the p-substituents. The products may be converted into salts with organic or inorganic bases such as diethanolamine or alkali or alkaline-earth metals Pharmaceutical preparations having antibacterial activity comprise the 4-sulphanilamido -5,6 - dialkoxy (or alkenyloxy) - pyrimidines of the invention, in admixture with a carrier or excipient. The preparation may be in solid or liquid form suitable or enteral (e.g. oral) or parenteral administration e.g. as tablets, dragees, suppositories, capsules, solutions, suspensions or emulsions and may contain preserving, stabilizing, wetting or emulsifying agents, salts for varying osmotic pressure or buffers. Specifications 946,486, 946,487 and 946,488 are referred to.
ES0269655A 1960-08-09 1961-08-08 Novel sulphonamides and a process for the manufacture thereof Expired ES269655A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH899460A CH403771A (en) 1960-08-09 1960-08-09 Process for the preparation of new sulfonamides of the pyrimidine series
CH326761A CH405322A (en) 1961-03-17 1961-03-17 Process for the preparation of new sulfonamides of the pyrimidine series

Publications (1)

Publication Number Publication Date
ES269655A1 true ES269655A1 (en) 1962-03-16

Family

ID=25692613

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0269655A Expired ES269655A1 (en) 1960-08-09 1961-08-08 Novel sulphonamides and a process for the manufacture thereof

Country Status (8)

Country Link
CY (1) CY297A (en)
ES (1) ES269655A1 (en)
FI (1) FI43990B (en)
FR (1) FR1442M (en)
GB (4) GB946488A (en)
MY (1) MY6500011A (en)
NL (1) NL267523A (en)
OA (1) OA00957A (en)

Also Published As

Publication number Publication date
OA00957A (en) 1968-03-22
NL267523A (en)
MY6500011A (en) 1965-12-31
GB946485A (en) 1964-01-15
CY297A (en) 1964-10-14
GB946488A (en) 1964-01-15
FR1442M (en) 1962-08-13
FI43990B (en) 1971-04-30
GB946486A (en) 1964-01-15
GB946487A (en) 1964-01-15

Similar Documents

Publication Publication Date Title
MY104375A (en) Vitamin d derivatives and process for their preparation.
US2407966A (en) Diazine compounds
GB970886A (en) New pyridines and process for the manufacture thereof
GB1155936A (en) Novel Sulphonamides and a Process for the Manufacture thereof
GB946485A (en) Novel sulphonamides and a process for the manufacture thereof
ES8306439A1 (en) Compositions on the basis of 5-hydroxy-tryptophane, manufacturing process and medicaments containing them.
GB1256849A (en)
GB1016071A (en) New guanidine derivatives and process for preparing the same
GB1434544A (en) Piperazino-pyrimidines process for their preparation and use
ES269656A1 (en) Novel sulphonamides and a process for their manufacture
IE33345L (en) Isothiazolopyrimidines.
GB1221407A (en) 0,2,3,4-tetrahydro-7-substituted-6-sulfamyl-4-quinazolinones, process for preparing the same and pharmaceutical compositions comprising the same
GB1117646A (en) 3-azabicyclo[3.2.2] nonane derivatives
ES273933A1 (en) Pyrimethamine salt with 2, 6-dihydroxyisonicotinic acid
GB860371A (en) Di-sulfonamides and compositions containing them
GB1254270A (en) Benzoxazepine derivatives
GB899362A (en) Quinazolone sulphonamides
GB1364521A (en) Aminoglycoside antibiotics
GB1052113A (en)
GB895625A (en) New benzene-sulphonyl benzyl-ureas and process of preparing them
GB1318859A (en) Imidazo-4,5-b-pyridine derivatives
GB1016527A (en) Quinazolinone derivatives and a process for the manufacture thereof
GB963419A (en) Novel sulphonamides and the manufacture thereof
GB831919A (en) Sulphonamide compounds and preparation thereof
GB1311444A (en) Cyclopentyl urea and process for its production