ES270024A1 - Un procedimiento para la preparaciën de derivados, esteres y sales de acido isoftalico - Google Patents

Un procedimiento para la preparaciën de derivados, esteres y sales de acido isoftalico

Info

Publication number: ES270024A1
Authority: ES; Spain
Prior art keywords: acid; amino; lower alkyl; ester; nitro
Prior art date: 1960-08-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES0270024A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mallinckrodt Chemical Inc

Original Assignee

Mallinckrodt Chemical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1960-08-25

Filing date

1961-08-21

Publication date

1962-01-01

1961-06-26 Priority claimed from US119287A external-priority patent/US3145197A/en

1961-08-21 Application filed by Mallinckrodt Chemical Inc filed Critical Mallinckrodt Chemical Inc

1962-01-01 Publication of ES270024A1 publication Critical patent/ES270024A1/es

Status Expired legal-status Critical Current

Links

150000002531 isophthalic acids Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000005907 alkyl ester group Chemical group 0.000 abstract 6
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 4
150000003973 alkyl amines Chemical class 0.000 abstract 4
239000000908 ammonium hydroxide Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 3
230000002083 iodinating effect Effects 0.000 abstract 3
BDXFKMQTIGVLEU-UHFFFAOYSA-N 3-carbamoyl-5-nitrobenzoic acid Chemical compound NC(=O)C1=CC(C(O)=O)=CC([N+]([O-])=O)=C1 BDXFKMQTIGVLEU-UHFFFAOYSA-N 0.000 abstract 2
KBZFDRWPMZESDI-UHFFFAOYSA-N 5-aminobenzene-1,3-dicarboxylic acid Chemical compound NC1=CC(C(O)=O)=CC(C(O)=O)=C1 KBZFDRWPMZESDI-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
ZCRNIIJXDRYWDU-UHFFFAOYSA-N 3-(methoxycarbonyl)-5-nitrobenzoic acid Chemical compound COC(=O)C1=CC(C(O)=O)=CC([N+]([O-])=O)=C1 ZCRNIIJXDRYWDU-UHFFFAOYSA-N 0.000 abstract 1
BWKWJRRDHNBJTI-UHFFFAOYSA-N 3-amino-5-carbamoyl-2,4,6-triiodobenzoic acid Chemical class NC(=O)C1=C(I)C(N)=C(I)C(C(O)=O)=C1I BWKWJRRDHNBJTI-UHFFFAOYSA-N 0.000 abstract 1
XHLMMVDCYIXUAX-UHFFFAOYSA-N 3-amino-5-carbamoylbenzoic acid Chemical compound NC(=O)C1=CC(N)=CC(C(O)=O)=C1 XHLMMVDCYIXUAX-UHFFFAOYSA-N 0.000 abstract 1
FVUKYCZRWSQGAS-UHFFFAOYSA-N 3-carbamoylbenzoic acid Chemical class NC(=O)C1=CC=CC(C(O)=O)=C1 FVUKYCZRWSQGAS-UHFFFAOYSA-N 0.000 abstract 1
NBDAHKQJXVLAID-UHFFFAOYSA-N 5-nitroisophthalic acid Chemical compound OC(=O)C1=CC(C(O)=O)=CC([N+]([O-])=O)=C1 NBDAHKQJXVLAID-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
-1 N-methyl glucamine salts Chemical class 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000002872 contrast media Substances 0.000 abstract 1
229940039231 contrast media Drugs 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 abstract 1
DQTOZIJNMYYCJE-UHFFFAOYSA-N methyl 3-carbonochloridoyl-5-nitrobenzoate Chemical compound COC(=O)C1=CC(C(Cl)=O)=CC([N+]([O-])=O)=C1 DQTOZIJNMYYCJE-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES0270024A 1960-08-25 1961-08-21 Un procedimiento para la preparaciën de derivados, esteres y sales de acido isoftalico Expired ES270024A1 (es)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US5178660A	1960-08-25	1960-08-25
US119287A US3145197A (en)	1961-06-26	1961-06-26	5-acetamido-nu-alkyl-2, 4, 6-trhodoiso-phthalamic acid compounds
US12138861A	1961-07-03	1961-07-03
US12537361A	1961-07-20	1961-07-20

Publications (1)

Publication Number	Publication Date
ES270024A1 true ES270024A1 (es)	1962-01-01

Family

ID=27489435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES0270024A Expired ES270024A1 (es)	1960-08-25	1961-08-21	Un procedimiento para la preparaciën de derivados, esteres y sales de acido isoftalico

Country Status (6)

Country	Link
BE (1)	BE607551A (fr)
CH (1)	CH424751A (fr)
DE (1)	DE1443297C3 (fr)
ES (1)	ES270024A1 (fr)
FR (1)	FR1589M (fr)
GB (1)	GB994215A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4801661B2 (ja) *	2005-03-18	2011-10-26	マナック株式会社	５−アミノ−２，４，６−トリヨードイソフタル酸誘導体のアセチル化方法

1961
- 1961-08-18 GB GB29941/61A patent/GB994215A/en not_active Expired
- 1961-08-21 ES ES0270024A patent/ES270024A1/es not_active Expired
- 1961-08-22 DE DE1443297A patent/DE1443297C3/de not_active Expired
- 1961-08-24 CH CH990261A patent/CH424751A/de unknown
- 1961-08-25 BE BE607551A patent/BE607551A/fr unknown
- 1961-11-09 FR FR878387A patent/FR1589M/fr not_active Expired

Also Published As

Publication number	Publication date
GB994215A (en)	1965-06-02
DE1443297B2 (de)	1974-08-29
DE1443297A1 (de)	1972-01-13
CH424751A (de)	1966-11-30
BE607551A (fr)	1962-02-26
FR1589M (fr)	1962-11-26
DE1443297C3 (de)	1975-04-17

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