ES2721018T3 - N-Acil-(3-sustituido)-(8-metil)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor NK-3, composición farmacéutica, métodos para su uso en trastornos mediados por el receptor de NK-3 - Google Patents

N-Acil-(3-sustituido)-(8-metil)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor NK-3, composición farmacéutica, métodos para su uso en trastornos mediados por el receptor de NK-3 Download PDF

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ES2721018T3
ES2721018T3 ES14713847T ES14713847T ES2721018T3 ES 2721018 T3 ES2721018 T3 ES 2721018T3 ES 14713847 T ES14713847 T ES 14713847T ES 14713847 T ES14713847 T ES 14713847T ES 2721018 T3 ES2721018 T3 ES 2721018T3
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receptor
methyl
pyrazines
triazolo
dihydro
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Hamid Hoveyda
Guillaume Dutheuil
Graeme Fraser
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Ogeda SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de Fórmula I:**Fórmula** o un solvato farmacéuticamente aceptable del mismo, en donde: R1 es H o F; R1' es H; R2 es H, F o Cl; R2' es H o F; R3 es F o Cl; R4 es metilo o trifluorometilo; X1 es S y X2 es N o X1 es CH y X2 es O; representa un enlace simple o doble dependiendo de X1 y X2; representa el enantiómero (R) o el racemato del compuesto de Fórmula I.
ES14713847T 2013-03-29 2014-03-28 N-Acil-(3-sustituido)-(8-metil)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor NK-3, composición farmacéutica, métodos para su uso en trastornos mediados por el receptor de NK-3 Active ES2721018T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13161866 2013-03-29
PCT/EP2014/056372 WO2014154897A1 (en) 2013-03-29 2014-03-28 NOVEL N-ACYL-(3-SUBSTITUTED)-(8-METHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS

Publications (1)

Publication Number Publication Date
ES2721018T3 true ES2721018T3 (es) 2019-07-26

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ES14713847T Active ES2721018T3 (es) 2013-03-29 2014-03-28 N-Acil-(3-sustituido)-(8-metil)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor NK-3, composición farmacéutica, métodos para su uso en trastornos mediados por el receptor de NK-3

Country Status (7)

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US (2) US9840508B2 (es)
EP (1) EP2989103B1 (es)
JP (1) JP6275242B2 (es)
AU (1) AU2014242908B2 (es)
CA (1) CA2907814C (es)
ES (1) ES2721018T3 (es)
WO (1) WO2014154897A1 (es)

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EP2552920B1 (en) 2010-04-02 2017-03-15 Ogeda Sa Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders
WO2013050424A1 (en) 2011-10-03 2013-04-11 Euroscreen S.A. NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
WO2014152537A1 (en) 2013-03-14 2014-09-25 Janssen Pharmaceutica Nv P2x7 modulators
TWI644671B (zh) 2013-03-14 2018-12-21 比利時商健生藥品公司 Ｐ２ｘ７調節劑
TWI627174B (zh) 2013-03-14 2018-06-21 比利時商健生藥品公司 Ｐ２ｘ７調控劑
ES2654288T3 (es) 2013-03-14 2018-02-13 Janssen Pharmaceutica, N.V. Moduladores de P2X7
US10183948B2 (en) 2013-03-29 2019-01-22 Ogeda Sa N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
PT2948455T (pt) 2013-03-29 2017-11-15 Ogeda S A N-acil-(3-substituído)-(8-substituído)-5,6-diidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas de recetor nk-3 seletivos, composição farmacêutica, métodos para utilização em distúrbios mediados por recetor nk-3
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EP2989103B1 (en) 2019-02-20
WO2014154897A1 (en) 2014-10-02
HK1218546A1 (en) 2017-02-24
AU2014242908A1 (en) 2015-10-22
JP6275242B2 (ja) 2018-02-07
US9840508B2 (en) 2017-12-12
CA2907814C (en) 2021-07-13
AU2014242908A2 (en) 2015-10-22
EP2989103A1 (en) 2016-03-02
US9969745B2 (en) 2018-05-15
US20180065972A1 (en) 2018-03-08
JP2016516741A (ja) 2016-06-09
AU2014242908B2 (en) 2018-07-19
US20160289233A1 (en) 2016-10-06
CA2907814A1 (en) 2014-10-02

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