ES273263A1 - Un metodo para producir un toxoide a partir de una toxina bacteriana purificada - Google Patents
Un metodo para producir un toxoide a partir de una toxina bacteriana purificadaInfo
- Publication number
- ES273263A1 ES273263A1 ES0273263A ES273263A ES273263A1 ES 273263 A1 ES273263 A1 ES 273263A1 ES 0273263 A ES0273263 A ES 0273263A ES 273263 A ES273263 A ES 273263A ES 273263 A1 ES273263 A1 ES 273263A1
- Authority
- ES
- Spain
- Prior art keywords
- diphtheria
- toxoids
- aliphatic diamine
- formaldehyde
- vaccines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 aliphatic diamine Chemical class 0.000 abstract 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 206010013023 diphtheria Diseases 0.000 abstract 3
- 231100000699 Bacterial toxin Toxicity 0.000 abstract 2
- 239000000688 bacterial toxin Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 206010043376 Tetanus Diseases 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960005097 diphtheria vaccines Drugs 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB50861A GB969772A (en) | 1961-01-05 | 1961-01-05 | Toxoids and their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES273263A1 true ES273263A1 (es) | 1962-07-01 |
Family
ID=9705586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0273263A Expired ES273263A1 (es) | 1961-01-05 | 1961-12-27 | Un metodo para producir un toxoide a partir de una toxina bacteriana purificada |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH455146A (es) |
| ES (1) | ES273263A1 (es) |
| GB (1) | GB969772A (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9216351D0 (en) * | 1992-07-31 | 1992-09-16 | Wellcome Found | Vaccine production |
| GB2495341B (en) * | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| GB2498112A (en) * | 2011-11-11 | 2013-07-03 | Novartis Ag | Preparation of a diphtheria toxoid by incubating toxin concentrate with an amino acid and formaldehyde |
| DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
| DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
| EP2592137A1 (en) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use |
-
1961
- 1961-01-05 GB GB50861A patent/GB969772A/en not_active Expired
- 1961-12-27 ES ES0273263A patent/ES273263A1/es not_active Expired
- 1961-12-29 CH CH1513061A patent/CH455146A/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH455146A (de) | 1968-04-30 |
| GB969772A (en) | 1964-09-16 |
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