ES273769A1 - Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico - Google Patents

Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico

Info

Publication number: ES273769A1
Authority: ES; Spain
Prior art keywords: carbon atoms; carboline; hydrogen; alkyl; carboxylic acid
Prior art date: 1961-01-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES0273769A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

JR Geigy AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1961-01-18

Filing date

1962-01-16

Publication date

1962-06-01

1962-01-16 Application filed by JR Geigy AG filed Critical JR Geigy AG

1962-06-01 Publication of ES273769A1 publication Critical patent/ES273769A1/es

Status Expired legal-status Critical Current

Links

238000002360 preparation method Methods 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 9
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
150000002825 nitriles Chemical class 0.000 abstract 2
CFTOTSJVQRFXOF-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Chemical group N1C2=CC=CC=C2C2=C1CNCC2 CFTOTSJVQRFXOF-UHFFFAOYSA-N 0.000 abstract 1
PIUZUYYLQPECCR-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonitrile Chemical class C(#N)C1NCC=2NC3=CC=CC=C3C=2C1 PIUZUYYLQPECCR-UHFFFAOYSA-N 0.000 abstract 1
RYLDZJANGRBUGW-UHFFFAOYSA-N 9h-pyrido[3,4-b]indole-3-carbonitrile Chemical class N1C2=CC=CC=C2C2=C1C=NC(C#N)=C2 RYLDZJANGRBUGW-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
238000007059 Strecker synthesis reaction Methods 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
-1 amino, hydrazino Chemical group 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000002140 halogenating effect Effects 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
XZECNVJPYDPBAM-ZDUSSCGKSA-N methyl (2s)-2-acetamido-3-(1h-indol-3-yl)propanoate Chemical compound C1=CC=C2C(C[C@@H](C(=O)OC)NC(C)=O)=CNC2=C1 XZECNVJPYDPBAM-ZDUSSCGKSA-N 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000007127 saponification reaction Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES0273769A 1961-01-18 1962-01-16 Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico Expired ES273769A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8339061A	1961-01-18	1961-01-18

Publications (1)

Publication Number	Publication Date
ES273769A1 true ES273769A1 (es)	1962-06-01

Family

ID=22177990

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
ES0273769A Expired ES273769A1 (es)	1961-01-18	1962-01-16	Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
ES0273996A Expired ES273996A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolina sustituidos basicamente
ES0273783A Expired ES273783A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolin-carboxilico
ES0273995A Expired ES273995A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolina sustituidos basicamente
ES0273997A Expired ES273997A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolina
ES0273999A Expired ES273999A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolina

Family Applications After (5)

Application Number	Title	Priority Date	Filing Date
ES0273996A Expired ES273996A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolina sustituidos basicamente
ES0273783A Expired ES273783A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolin-carboxilico
ES0273995A Expired ES273995A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolina sustituidos basicamente
ES0273997A Expired ES273997A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolina
ES0273999A Expired ES273999A1 (es)	1961-01-18	1962-01-17	Procedimiento para la preparaciën de nuevos derivados de beta-carbolina

Country Status (5)

Country	Link
AT (1)	AT239788B (fr)
BE (4)	BE612725A (fr)
ES (6)	ES273769A1 (fr)
FR (3)	FR1825M (fr)
GB (1)	GB975835A (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1084256A (fr) *	1963-11-06
NZ194747A (en) *	1979-08-29	1988-11-29	Schering Ag	9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
FR2487829A2 (fr) *	1979-12-07	1982-02-05	Science Union & Cie	Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
JPS57123180A (en) *	1980-12-17	1982-07-31	Schering Ag	3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3247615A1 (de) *	1982-12-23	1984-07-05	Hoechst Ag, 6230 Frankfurt	Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2140797A (en) *	1983-06-04	1984-12-05	Tanabe Seiyaku Co	Tetrahydro-b-carboline derivatives
GB8330260D0 (en) *	1983-11-12	1983-12-21	Tanabe Seiyaku Co	Tetrahydro-beta-carboline derivatives
DE3535928A1 (de) *	1985-10-04	1987-04-09	Schering Ag	Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0347980A1 (fr) *	1988-06-20	1989-12-27	Duphar International Research B.V	B-carbolines, 8,9-cyclisées et B-carbolines, 3,4-dihydro, 8,9 cyclisées
EP0357122A3 (fr) *	1988-08-29	1991-10-23	Duphar International Research B.V	L'application des bêta-carbolines, benzofurane et benzothiophène analogues pour obtenir un médicament à activité cytostatique
FR2724384B1 (fr) *	1994-09-14	1999-04-16	Cemaf	Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
DE4436190A1 (de) *	1994-10-10	1996-04-11	Gerhard Prof Dr Bringmann	Halogenierte ß-Carbolin-Derivate, Verfahren zu ihrer Herstellung und Verwendung dieser Substanzen zur Hemmung der Atmungskette
EP1383765B1 (fr) *	2001-04-25	2006-12-13	Lilly Icos LLC	Dérives de carboline en tant qu'inhibiteurs de phosphodiesterase 5 (PDE 5) pour le traitement des maladies cardiovasculaires et le dysfonctionnement érectile
CN100503607C (zh) *	2003-06-02	2009-06-24	新疆华世丹药物研究有限责任公司	去氢骆驼蓬碱衍生物类化合物及其应用
CN103596949A (zh)	2011-03-28	2014-02-19	Sjt分子研究有限公司	用于代谢综合征的治疗的化合物
US10392385B2 (en)	2016-01-22	2019-08-27	Council Of Scientific & Industrial Research	N-((1-phenyl-9H-pyrido[3,4-b]indol-3-yl)methyl)cinnamamides as potential anticancer agents and preparation thereof

1962
- 1962-01-16 ES ES0273769A patent/ES273769A1/es not_active Expired
- 1962-01-17 ES ES0273996A patent/ES273996A1/es not_active Expired
- 1962-01-17 ES ES0273783A patent/ES273783A1/es not_active Expired
- 1962-01-17 BE BE612725A patent/BE612725A/fr unknown
- 1962-01-17 BE BE612728A patent/BE612728A/fr unknown
- 1962-01-17 ES ES0273995A patent/ES273995A1/es not_active Expired
- 1962-01-17 GB GB1653/62A patent/GB975835A/en not_active Expired
- 1962-01-17 ES ES0273997A patent/ES273997A1/es not_active Expired
- 1962-01-17 AT AT124063A patent/AT239788B/de active
- 1962-01-17 BE BE612727A patent/BE612727A/fr unknown
- 1962-01-17 ES ES0273999A patent/ES273999A1/es not_active Expired
- 1962-01-17 BE BE612726A patent/BE612726A/fr unknown
- 1962-04-16 FR FR894618A patent/FR1825M/fr active Active
- 1962-04-16 FR FR894619A patent/FR1836M/fr active Active
- 1962-04-16 FR FR894620A patent/FR1837M/fr active Active

Also Published As

Publication number	Publication date
BE612725A (fr)	1962-07-17
ES273995A1 (es)	1962-06-01
BE612728A (fr)	1962-07-17
ES273999A1 (es)	1962-06-01
ES273996A1 (es)	1962-06-01
FR1825M (fr)	1963-05-20
BE612727A (fr)	1962-07-17
ES273783A1 (es)	1962-06-01
AT239788B (de)	1965-04-26
FR1836M (fr)	1963-05-27
FR1837M (fr)	1963-05-27
ES273997A1 (es)	1962-06-01
GB975835A (en)	1964-11-18
BE612726A (fr)	1962-07-17

Publication	Publication Date	Title
ES273769A1 (es)	1962-06-01	Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
ES391497A1 (es)	1973-06-16	Procedimiento para la preparacion de nuevos derivados de ciclohepteno.
ES382550A1 (es)	1973-04-16	Procedimiento para la preparacion de nuevas 2-aminoalcohi- lamino-tieno (3,2-d) pirimidinas.
AU614074B2 (en)	1991-08-22	Substituted pyridine-2,4-dicarboxylic acid derivatives, processes for their preparation, the use thereof and medicaments based on these compounds
ES392290A1 (es)	1973-11-16	Procedimiento para la preparacion de derivados de acido quinoleincarboxilico.
GB1155017A (en)	1969-06-11	Hydrazine Compounds and process for their manufacture
ES429959A1 (es)	1977-02-01	Procedimiento para la preparacion de nuevos compuestos analogos de acidos prostanoicos, no presentes en la naturaleza
GB1489332A (en)	1977-10-19	Reduced bicyclic pyridone derivatives
GB1389461A (en)	1975-04-03	Pyridine-acetic acid derivatives
ES366540A1 (es)	1971-01-01	Procedimiento para la preparacion de nuevos alcoholes fene-tilicos sustituidos y sus esteres.
TAKAMURA et al.	1976	Amino Acids and Peptides. XX. Reduction of α-Substituted α-Diazo Esters. Convenient Synthesis of α-Hydrazinocarboxylic Acids and Their Derivatives from α-Amino Acids
GB1150397A (en)	1969-04-30	New Indole-4-Acetic Acid Compounds and Methods for Their Production
ES406125A1 (es)	1975-08-01	Procedimiento para la preparacion de acidos 4-(4-bifeni- lil)-butiricos y sus esteres.
GB1351577A (en)	1974-05-01	Bis-basic esters of fluorene and fluorenone
GB862513A (en)	1961-03-08	Pyrrolidine compounds and methods for producing the same
ES418270A1 (es)	1976-03-01	Procedimiento para la preparacion de acidos 7-amino-3-cefem-carboxilicos.
GB1045544A (en)	1966-10-12	New derivatives of pyrazolidines their production and use
GB1107036A (en)	1968-03-20	Esters of dibenzocycloheptenyl-carboxylic acids
ES278796A1 (es)	1963-03-01	Procedimiento para la preparaciën de nuevos fenil-uracilos
ES327314A1 (es)	1967-07-16	Procedimiento para la preparacion de esteres de acidos alfaaminocarboxilicos.
GB1512168A (en)	1978-05-24	Process for preparing 1-(beta-cyanoethylamino)-3-acylaminobenzenes
GB1411666A (en)	1975-10-29	Tetrahydro-1,4-oxazines and process for preparing the same
GB1116608A (en)	1968-06-06	New dibenzocycloheptadiene derivatives
GB1197467A (en)	1970-07-08	Improvements in or relating to a Process for the Production of Substituted 1,4-Dienes
ES383342A1 (es)	1973-01-01	Procedimiento para la preparacion de nuevos derivados de labencensulfonamida.