ES2738100T3 - Método de fabricación de una vacuna contra micoplasma - Google Patents
Método de fabricación de una vacuna contra micoplasma Download PDFInfo
- Publication number
- ES2738100T3 ES2738100T3 ES13817835T ES13817835T ES2738100T3 ES 2738100 T3 ES2738100 T3 ES 2738100T3 ES 13817835 T ES13817835 T ES 13817835T ES 13817835 T ES13817835 T ES 13817835T ES 2738100 T3 ES2738100 T3 ES 2738100T3
- Authority
- ES
- Spain
- Prior art keywords
- mycoplasma
- mycoplasma bacteria
- antigen
- culture
- manufacturing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/70—Non-animal cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Developmental Biology & Embryology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un método para la preparación de una composición inmunogénica para el tratamiento y/o la profilaxis de infecciones por micoplasma en un sujeto que comprende: a.) cultivo de bacterias micoplasma en un sistema de células eucariotas reducido en suero, en el que dicho sistema de células eucariotas comprende una estirpe celular MDCK o una estirpe celular Mc Coy; b.) obtención de un antígeno de las bacterias micoplasma; y c.) adición de un vehículo farmacéuticamente aceptable, en el que la composición inmunogénica comprende bacterias micoplasma seleccionadas entre la lista que contiene: M. hyopneumoniae, M. hyorhinis y M. hyosynoviae y, en el que el antígeno es una bacterina inactivada completa, en el que el cultivo de las bacterias micoplasma en el sistema de células eucariotas incluye concentraciones de suero entre el 0-10 % (v/v).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746997P | 2012-12-28 | 2012-12-28 | |
| PCT/US2013/076807 WO2014105672A1 (en) | 2012-12-28 | 2013-12-20 | Method of making a mycoplasma vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2738100T3 true ES2738100T3 (es) | 2020-01-20 |
Family
ID=49917778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13817835T Active ES2738100T3 (es) | 2012-12-28 | 2013-12-20 | Método de fabricación de una vacuna contra micoplasma |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9273281B2 (es) |
| EP (1) | EP2938747B1 (es) |
| JP (2) | JP6122146B2 (es) |
| KR (1) | KR102153275B1 (es) |
| CN (2) | CN104968365B (es) |
| AR (1) | AR094648A1 (es) |
| AU (1) | AU2013370983B2 (es) |
| BR (1) | BR112015012711B1 (es) |
| CA (1) | CA2896298C (es) |
| CL (1) | CL2015001562A1 (es) |
| DK (1) | DK2938747T3 (es) |
| EA (1) | EA032772B1 (es) |
| ES (1) | ES2738100T3 (es) |
| HU (1) | HUE045015T2 (es) |
| MX (2) | MX361273B (es) |
| MY (1) | MY173223A (es) |
| PH (1) | PH12015501333B1 (es) |
| PL (1) | PL2938747T3 (es) |
| PT (1) | PT2938747T (es) |
| SG (2) | SG11201505089YA (es) |
| TW (2) | TWI660736B (es) |
| UA (1) | UA121193C2 (es) |
| WO (1) | WO2014105672A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8546149B2 (en) | 2010-08-27 | 2013-10-01 | Intervet Inc. | Potency test for vaccine formulations |
| PT2938747T (pt) | 2012-12-28 | 2019-08-01 | Boehringer Ingelheim Vetmedica Gmbh | Método de preparação de uma vacina de micoplasma |
| SG11201505086QA (en) * | 2012-12-28 | 2015-07-30 | Boehringer Ingelheim Vetmed | Immunogenic composition comprising mycoplasma antigens |
| CN105441368B (zh) * | 2016-01-19 | 2019-01-01 | 福清市默克兽医院 | 一株牛支原体及其应用 |
| EP3408281A4 (en) * | 2016-01-29 | 2019-08-14 | Advanced Animal Diagnostics, Inc. | METHOD AND COMPOSITIONS FOR DETECTING MYCOPLASMA EXPOSURE |
| AU2017238217A1 (en) | 2016-03-22 | 2018-10-11 | Advanced Animal Diagnostics, Inc. | Methods and compositions for reducing antibiotic administration to farm animals |
| BR112019002614A2 (pt) * | 2016-08-09 | 2019-07-02 | Agricultural Technology Research Institute | composição para prevenir e tratar mycoplasma hyorhinis, método para produzir a referida composição, vetor de expressão para produção do ingrediente ativo da composição, e método para a produção de uma proteína solúvel |
| US20180221407A1 (en) * | 2017-02-03 | 2018-08-09 | The Administrators Of The Tulane Educational Fund | Ophthalmic compositions for therapeutic and prophylactic uses |
| EP3632982A4 (en) | 2017-05-24 | 2020-04-08 | Mitsubishi Chemical Corporation | MOLDING MATERIAL, AND FIBER REINFORCED COMPOSITE MATERIAL |
| US20220235313A1 (en) | 2019-06-10 | 2022-07-28 | ELANCO US, Inc. | Mycoplasma media formulations |
| CN113201050B (zh) * | 2020-08-06 | 2022-07-22 | 青岛诺安百特生物技术有限公司 | 一种金黄色葡萄球菌噬菌体穿孔素及其制备方法和应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2909462A (en) | 1955-12-08 | 1959-10-20 | Bristol Myers Co | Acrylic acid polymer laxative compositions |
| GB1074920A (en) * | 1965-04-21 | 1967-07-05 | Pfizer & Co C | Growth medium for mycoplasma pneumoniae and vaccine production |
| GB1137306A (en) * | 1966-07-11 | 1968-12-18 | Research Corp | Inoculum for poultry |
| JPS5540568B2 (es) | 1972-10-05 | 1980-10-18 | ||
| US5338543A (en) | 1992-02-27 | 1994-08-16 | Ambico, Inc. | Thimerosal inactivated mycoplasma hyopneumoniae vaccine |
| US5885823A (en) | 1995-06-05 | 1999-03-23 | Nobl Laboratories, Inc. | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents |
| KR100797547B1 (ko) * | 2000-03-03 | 2008-01-24 | 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 무혈청 배양 및 부유 배양에서 사용할 수 있는 세포 및상기 세포를 사용하여 백신용 바이러스를 제조하는 방법 |
| JP3402304B2 (ja) * | 2000-03-30 | 2003-05-06 | 株式会社微生物化学研究所 | 猫クラミジアワクチンの製造方法 |
| MY129765A (en) | 2000-12-19 | 2007-04-30 | Wyeth Corp | Improved mycoplasma hyopneumoniae bacterin vaccine |
| US7018638B2 (en) | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
| US20030147914A1 (en) | 2001-07-02 | 2003-08-07 | Pfizer Inc. | Mycoplasma bovis vaccine and methods of reducing pneumonia in animals |
| WO2003003941A2 (en) | 2001-07-02 | 2003-01-16 | Pfizer Products Inc. | One dose vaccination with mycoplasma hyopneumoniae |
| WO2003004051A2 (en) | 2001-07-02 | 2003-01-16 | Pfizer Products Inc. | Mycoplasma hyopneumoniae vaccine and methods for reducing mycoplasma bovis pneumonia in cattle |
| IL159145A0 (en) | 2001-08-28 | 2004-06-01 | Pfizer Prod Inc | Mycoplasma bovis challenge model, methods for administering m. bovis and methods for inducing pneumonic lung lesions |
| TWI238721B (en) | 2003-06-20 | 2005-09-01 | Animal Technology Inst Taiwan | Swine enzootic vaccine, its producing method and usage |
| US20080185755A1 (en) | 2005-02-09 | 2008-08-07 | Todd Deaville | Method of Manufacturing a semi-Structural Panel |
| JP4693839B2 (ja) * | 2005-03-10 | 2011-06-01 | 共立製薬株式会社 | 動物由来の成分なしで培養可能である細胞株及びその作出方法、これを用いたウイルスの生産方法、及びワクチンの生産方法 |
| WO2007042827A2 (en) * | 2005-10-14 | 2007-04-19 | Ivan Petyaev | Treatment and diagnosis of obligate intracellular pathogens |
| EP2615167A1 (en) | 2006-09-15 | 2013-07-17 | MedImmune, LLC | Method for eliminating DNA contaminants from viral preparations |
| US20090068231A1 (en) | 2007-09-11 | 2009-03-12 | Wyeth | Live attenuated mycoplasma strains |
| AR069087A1 (es) | 2007-10-29 | 2009-12-30 | Boehringer Ingelheim Vetmed | Cepa bacteriana de m. bovis atenuada avirulenta obtenida por pases, vacuna de micoplasma boris y metodos de uso de la misma |
| UA98812C2 (ru) | 2007-11-06 | 2012-06-25 | Вайет Ллк | Авирулентная активированная живая вакцина mycoplasma hyopneumoniae |
| KR20100113582A (ko) | 2008-01-23 | 2010-10-21 | 베링거잉겔하임베트메디카인코퍼레이티드 | Ｐｃｖ2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법 |
| US8444989B1 (en) | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
| WO2009142086A1 (ja) | 2008-05-23 | 2009-11-26 | 学校法人久留米大学 | マイコプラズマ感染症用ワクチン組成物 |
| ES2569907T3 (es) | 2008-06-27 | 2016-05-13 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
| MX2011004316A (es) | 2008-10-31 | 2011-06-16 | Boehringer Ingelheim Vetmed | Uso de antigenos diversos que incluyen antigenos de mycoplasma bovis en composicion de vacuna multivalente. |
| WO2010132932A1 (en) | 2009-05-19 | 2010-11-25 | Bioproperties Pty Ltd | A temperature sensitive vaccine strain of mycoplasma hyopneumoniae and uses thereof |
| WO2011075379A1 (en) | 2009-12-18 | 2011-06-23 | Boehringer Ingelheim Vetmedica, Inc. | Multivalent vaccine against porcine teschovirus and other disease causing organisms in swine |
| US8112663B2 (en) | 2010-03-26 | 2012-02-07 | Lsi Corporation | Method to establish redundancy and fault tolerance better than RAID level 6 without using parity |
| CN102258776B (zh) | 2011-07-07 | 2013-07-10 | 普莱柯生物工程股份有限公司 | 猪肺炎支原体、猪鼻支原体二联灭活疫苗及其制备方法 |
| US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
| UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
| UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
| SG11201505086QA (en) * | 2012-12-28 | 2015-07-30 | Boehringer Ingelheim Vetmed | Immunogenic composition comprising mycoplasma antigens |
| PT2938747T (pt) | 2012-12-28 | 2019-08-01 | Boehringer Ingelheim Vetmedica Gmbh | Método de preparação de uma vacina de micoplasma |
-
2013
- 2013-12-20 PT PT13817835T patent/PT2938747T/pt unknown
- 2013-12-20 EA EA201500701A patent/EA032772B1/ru not_active IP Right Cessation
- 2013-12-20 US US14/135,796 patent/US9273281B2/en active Active
- 2013-12-20 MX MX2015007730A patent/MX361273B/es active IP Right Grant
- 2013-12-20 WO PCT/US2013/076807 patent/WO2014105672A1/en not_active Ceased
- 2013-12-20 SG SG11201505089YA patent/SG11201505089YA/en unknown
- 2013-12-20 CN CN201380066001.XA patent/CN104968365B/zh active Active
- 2013-12-20 SG SG10201708028VA patent/SG10201708028VA/en unknown
- 2013-12-20 JP JP2015549759A patent/JP6122146B2/ja active Active
- 2013-12-20 PL PL13817835T patent/PL2938747T3/pl unknown
- 2013-12-20 ES ES13817835T patent/ES2738100T3/es active Active
- 2013-12-20 DK DK13817835.5T patent/DK2938747T3/da active
- 2013-12-20 MX MX2018014818A patent/MX384875B/es unknown
- 2013-12-20 BR BR112015012711-8A patent/BR112015012711B1/pt active IP Right Grant
- 2013-12-20 KR KR1020157020447A patent/KR102153275B1/ko active Active
- 2013-12-20 HU HUE13817835 patent/HUE045015T2/hu unknown
- 2013-12-20 AU AU2013370983A patent/AU2013370983B2/en not_active Ceased
- 2013-12-20 UA UAA201507463A patent/UA121193C2/uk unknown
- 2013-12-20 CA CA2896298A patent/CA2896298C/en active Active
- 2013-12-20 CN CN201810161003.1A patent/CN108379571A/zh active Pending
- 2013-12-20 EP EP13817835.5A patent/EP2938747B1/en active Active
- 2013-12-20 PH PH1/2015/501333A patent/PH12015501333B1/en unknown
- 2013-12-20 MY MYPI2015001621A patent/MY173223A/en unknown
- 2013-12-27 AR ARP130105050A patent/AR094648A1/es unknown
- 2013-12-27 TW TW107103700A patent/TWI660736B/zh active
- 2013-12-27 TW TW102148875A patent/TWI618542B/zh active
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2015
- 2015-06-05 CL CL2015001562A patent/CL2015001562A1/es unknown
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2016
- 2016-01-19 US US15/000,342 patent/US10512680B2/en active Active
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2017
- 2017-03-30 JP JP2017067820A patent/JP6449364B2/ja active Active
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