ES2779975T3 - Métodos y composiciones para tratar el crecimiento celular anormal - Google Patents

Métodos y composiciones para tratar el crecimiento celular anormal Download PDF

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Publication number: ES2779975T3
Authority: ES; Spain
Prior art keywords: cancer; inhibitor; administered; pharmaceutically acceptable; fak
Prior art date: 2014-02-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES15746033T

Other languages

English (en)

Spanish (es)

Inventor

Qunli Xu

Jonathan A Pachter

Winnie Tam

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Verastem Inc

Original Assignee

Verastem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-02-07

Filing date

2015-02-06

Publication date

2020-08-21

2015-02-06 Application filed by Verastem Inc filed Critical Verastem Inc

2020-08-21 Application granted granted Critical

2020-08-21 Publication of ES2779975T3 publication Critical patent/ES2779975T3/es

Status Active legal-status Critical Current

2035-02-06 Anticipated expiration legal-status Critical

Links

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Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
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Physiology (AREA)
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Diabetes (AREA)
Endocrinology (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Mechanical Treatment Of Semiconductor (AREA)

ES15746033T 2014-02-07 2015-02-06 Métodos y composiciones para tratar el crecimiento celular anormal Active ES2779975T3 (es)

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US201461937253P	2014-02-07	2014-02-07
PCT/US2015/014843 WO2015120289A1 (en)	2014-02-07	2015-02-06	Methods and compositions for treating abnormal cell growth

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ES15746033T Active ES2779975T3 (es)	2014-02-07	2015-02-06	Métodos y composiciones para tratar el crecimiento celular anormal
ES20154659T Active ES2945387T3 (es)	2014-02-07	2015-02-06	Procedimientos y composiciones para tratar el crecimiento celular anormal

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ES20154659T Active ES2945387T3 (es)	2014-02-07	2015-02-06	Procedimientos y composiciones para tratar el crecimiento celular anormal

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US (4)	US9962385B2 (2)
EP (2)	EP3102232B1 (2)
JP (3)	JP2017505321A (2)
DK (2)	DK3102232T3 (2)
ES (2)	ES2779975T3 (2)
FI (1)	FI3698790T3 (2)
WO (1)	WO2015120289A1 (2)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3091981B1 (en) *	2014-01-09	2021-03-10	Verastem, Inc.	Compositions and methods for treatment of abnormal cell growth
US10532056B2 (en)	2015-06-29	2020-01-14	Verastem, Inc.	Therapeutic compositions, combinations, and methods of use
US20200046700A1 (en) *	2017-02-13	2020-02-13	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Focal adhesion kinase inhibitor as a therapeutic agent in diabetes
IL257225A (en) *	2018-01-29	2018-04-09	Yeda Res & Dev	Treatment of sarcoma
CA3130930A1 (en) *	2019-03-19	2020-09-24	Kyuson Yun	Methods and systems for evaluation of cell samples
US20220249484A1 (en) *	2019-05-17	2022-08-11	Memorial Sloan Kettering Cancer Center	Methods for predicting responsiveness of cancer to ferroptosis-inducing therapies
AU2020297587B2 (en)	2019-06-21	2026-03-19	Pattern Computer, Inc.	Therapeutic compositions and methods for treating cancers
JP2022547358A (ja)	2019-09-13	2022-11-14	ジインスティテュートオブキャンサーリサーチ：ロイヤルキャンサーホスピタル	治療組成物、組み合わせ、及び使用方法
EP4062914A4 (en) *	2019-11-18	2024-01-17	Inxmed (Nanjing) Co., Ltd.	USE OF AN FAK INHIBITOR IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF TUMORS PRESENTING AN NRAS MUTATION
MX2022006366A (es) *	2019-11-27	2022-06-22	Turning Point Therapeutics Inc	Terapia de combinacion que implica compuestos de diarilo macrociclico.
AU2021206684B2 (en)	2020-01-10	2024-01-18	Immuneering Corporation	MEK inhibitors and therapeutic uses thereof
WO2021154929A1 (en) *	2020-01-31	2021-08-05	Verastem, Inc.	Combination therapy for treating abnormal cell growth
EP4101453A4 (en)	2020-02-05	2024-05-15	Inxmed (Nanjing) Co., Ltd.	COMBINATION OF BI853520 WITH CHEMOTHERAPEUTIC DRUGS
BR112023000675A2 (pt) *	2020-07-13	2023-04-25	Verastem Inc	Terapia de combinação para tratamento de crescimento celular anormal
JP2024505680A (ja) *	2021-02-05	2024-02-07	ベラステム・インコーポレーテッド	異常な細胞成長を処置するための併用療法
TW202313044A (zh)	2021-08-16	2023-04-01	大陸商應世生物科技（南京）有限公司	Ｉｎ１００１８與ｐｌｄ的聯用
US11873296B2 (en)	2022-06-07	2024-01-16	Verastem, Inc.	Solid forms of a dual RAF/MEK inhibitor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101678215B (zh) *	2007-04-18	2014-10-01	辉瑞产品公司	用于治疗异常细胞生长的磺酰胺衍生物
CA2776944A1 (en) *	2009-10-12	2011-05-12	F. Hoffmann-La Roche Ag	Combinations of a pi3k inhibitor and a mek inhibitor
WO2012045194A1 (en) *	2010-10-09	2012-04-12	Abbott Laboratories	Benzodiazepinones as fak inhibitors for treatment of cancer
AR084216A1 (es)	2010-12-09	2013-05-02	Sanofi Sa	Composiciones y metodos para tratar el cancer usando un inhibidor de pi3k e inhibidor de mek, kit
US20130004481A1 (en)	2011-01-12	2013-01-03	Boehringer Ingelheim International Gmbh	Anticancer therapy
US20150071918A1 (en) *	2012-05-09	2015-03-12	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Peptides for the treatment of cancer
BR112014028376A2 (pt) *	2012-06-08	2018-04-24	Hoffmann La Roche	métodos para o tratamento de um distúrbio hiperproliferativo, para a determinação dos compostos, para monitorar, para optimizar a eficácia terapêutica e de identificação de um biomarcador; formulação farmacêutica; utilização de uma combinação terapêutica e de gdc-0032, artigo de manufatura, produto e invenção
WO2014059095A1 (en) *	2012-10-12	2014-04-17	Glaxosmithkline Llc	Combinations

2015
- 2015-02-06 WO PCT/US2015/014843 patent/WO2015120289A1/en not_active Ceased
- 2015-02-06 EP EP15746033.8A patent/EP3102232B1/en active Active
- 2015-02-06 FI FIEP20154659.5T patent/FI3698790T3/fi active
- 2015-02-06 DK DK15746033.8T patent/DK3102232T3/da active
- 2015-02-06 DK DK20154659.5T patent/DK3698790T3/da active
- 2015-02-06 ES ES15746033T patent/ES2779975T3/es active Active
- 2015-02-06 ES ES20154659T patent/ES2945387T3/es active Active
- 2015-02-06 EP EP20154659.5A patent/EP3698790B1/en active Active
- 2015-02-06 US US15/116,712 patent/US9962385B2/en active Active
- 2015-02-06 JP JP2016550218A patent/JP2017505321A/ja not_active Withdrawn
2018
- 2018-04-02 US US15/943,229 patent/US10406158B2/en active Active
2019
- 2019-07-23 US US16/519,605 patent/US20200147080A1/en not_active Abandoned
2020
- 2020-03-02 JP JP2020034703A patent/JP7289807B2/ja active Active
2022
- 2022-06-17 JP JP2022098159A patent/JP7578643B2/ja active Active
- 2022-11-17 US US17/989,006 patent/US20230321097A1/en active Pending

Also Published As

Publication number	Publication date
US10406158B2 (en)	2019-09-10
US20190046531A1 (en)	2019-02-14
FI3698790T3 (fi)	2023-06-06
HK1232152A1 (en)	2018-01-05
DK3102232T3 (da)	2020-04-20
US9962385B2 (en)	2018-05-08
JP7578643B2 (ja)	2024-11-06
JP2017505321A (ja)	2017-02-16
JP2022113886A (ja)	2022-08-04
WO2015120289A1 (en)	2015-08-13
EP3102232A4 (en)	2017-09-27
DK3698790T3 (da)	2023-06-19
EP3102232B1 (en)	2020-02-05
JP2020079320A (ja)	2020-05-28
US20160346282A1 (en)	2016-12-01
EP3102232A1 (en)	2016-12-14
US20230321097A1 (en)	2023-10-12
ES2945387T3 (es)	2023-06-30
EP3698790B1 (en)	2023-04-05
US20200147080A1 (en)	2020-05-14
JP7289807B2 (ja)	2023-06-12
EP3698790A1 (en)	2020-08-26

Publication	Publication Date	Title
JP7578643B2 (ja)	2024-11-06	異常な細胞成長を処置するための方法および組成物
EP4096671B1 (en)	2026-05-06	Combination therapy for treating abnormal cell growth
US12280050B2 (en)	2025-04-22	Therapeutic compositions, combinations, and methods of use
ES2987376T3 (es)	2024-11-14	Composiciones terapéuticas, combinaciones y métodos de uso
JP2022172480A5 (2)	2023-12-08
HK40036798A (en)	2021-06-04	Methods for treating abnormal cell growth
HK1232152B (en)	2020-12-31	Methods and compositions for treating abnormal cell growth
HK40075762A (en)	2023-01-27	Vs-6063 in combination with ch5126766 for the treatment of cancer