ES282860A2 - Un procedimiento para la preparación de derivados de 6-metil y 1,6-dimetil ergolina ii - Google Patents

Un procedimiento para la preparación de derivados de 6-metil y 1,6-dimetil ergolina ii

Info

Publication number: ES282860A2
Authority: ES; Spain
Prior art keywords: methyl; amide; derivatives; preparation; heteroatoms
Prior art date: 1961-11-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES282860A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Italia SRL

Original Assignee

Farmaceutici Italia SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1961-11-28

Filing date

1962-11-27

Publication date

1963-12-01

1962-11-27 Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA

1963-12-01 Publication of ES282860A2 publication Critical patent/ES282860A2/es

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical compound O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title 1
150000001408 amides Chemical class 0.000 abstract 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001540 azides Chemical class 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
UNELDXFWWQRODL-IUODEOHRSA-N (6ar,10ar)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline Chemical compound C1=CC([C@H]2CCCN([C@@H]2C2)C)=C3C2=CN(C)C3=C1 UNELDXFWWQRODL-IUODEOHRSA-N 0.000 abstract 1
MCCXTHKWNDYNKL-HUFXEGEASA-N (6ar,9r)-4,7-dimethyl-5,5a,6,6a,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxylic acid Chemical compound C([C@H](CN(C)[C@@H]1C2)C(O)=O)=C1C1=CC=CC3=C1C2CN3C MCCXTHKWNDYNKL-HUFXEGEASA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000001033 ether group Chemical group 0.000 abstract 1
IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES282860A 1961-11-28 1962-11-27 Un procedimiento para la preparación de derivados de 6-metil y 1,6-dimetil ergolina ii Expired ES282860A2 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2138661		1961-11-28

Publications (1)

Publication Number	Publication Date
ES282860A2 true ES282860A2 (es)	1963-12-01

Family

ID=11180988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES282860A Expired ES282860A2 (es)	1961-11-28	1962-11-27	Un procedimiento para la preparación de derivados de 6-metil y 1,6-dimetil ergolina ii

Country Status (4)

Country	Link
BE (1)	BE625369R (es)
CH (1)	CH464946A (es)
ES (1)	ES282860A2 (es)
GB (1)	GB970963A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3014410A1 (de) *	1980-04-15	1981-10-22	Meditest Institut für medizinisch-pharmazeutische Untersuchungen GmbH & Co KG, 7958 Laupheim	Neue heterocyclische verbindungen

1962
- 1962-11-23 GB GB44446/62A patent/GB970963A/en not_active Expired
- 1962-11-26 CH CH1385562A patent/CH464946A/de unknown
- 1962-11-27 ES ES282860A patent/ES282860A2/es not_active Expired
- 1962-11-27 BE BE625369A patent/BE625369R/fr active

Also Published As

Publication number	Publication date
GB970963A (en)	1964-09-23
BE625369R (fr)	1963-03-15
CH464946A (de)	1968-11-15

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