ES285014A1 - Procedure for the preparation of 3-methylene-steroids (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 3-methylene-steroids (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES285014A1 ES285014A1 ES0285014A ES285014A ES285014A1 ES 285014 A1 ES285014 A1 ES 285014A1 ES 0285014 A ES0285014 A ES 0285014A ES 285014 A ES285014 A ES 285014A ES 285014 A1 ES285014 A1 ES 285014A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- methyl
- hydrogen
- translation
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 238000007239 Wittig reaction Methods 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 150000004653 carbonic acids Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 150000002641 lithium Chemical group 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Abstract
Process for the preparation of 3-methylenesteroids, of the formula I ** (See formula) ** in which R1 means hydrogen or methyl, R2 means hydrogen or the group R4CO-, R3 means hydrogen, methyl or ethyl, and R4 means an aliphatic, cycloaliphatic, olefinic, aromatic or araliphatic hydrocarbon radical having 1 to 12 carbon atoms, characterized in that a 3-keto-steroid of the formula II is reacted ** (See formula) ** in which R1, R2 and R3 have the indicated significance for formula I, under the conditions of a Wittig reaction with a triarylphosphinmethylene of the formula Ar1Ar2Ar3P = CH2 in which Ar1, Ar2 and Ar3 mean phenyl or substituted phenyl radicals the same or different, or why a 17-keto-steroid of the formula III is reacted ** (See formula) ** in which R1 means hydrogen or methyl, with an organo-metallic reactant of the formula ** (See formula) ** in which R3 means methyl or ethyl, And it means a lithium atom or the group -MGX, and X means a chlorine, bromine or iodine atom, and in that a compound of the formula I, in which R 2 is hydrogen, is optionally esterified with an organic carbonic acid or a derivative of one of said carbonic acids, suitable for esterification. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE285014X | 1962-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES285014A1 true ES285014A1 (en) | 1963-07-16 |
Family
ID=38569966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0285014A Expired ES285014A1 (en) | 1962-02-10 | 1963-02-09 | Procedure for the preparation of 3-methylene-steroids (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES285014A1 (en) |
-
1963
- 1963-02-09 ES ES0285014A patent/ES285014A1/en not_active Expired
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