ES288887A1 - Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-ergolina - Google Patents

Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-ergolina

Info

Publication number: ES288887A1
Authority: ES; Spain
Prior art keywords: methyl; hydrogen; ergoline; translation; dimethyl
Prior art date: 1962-06-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES288887A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Italia SRL

Original Assignee

Farmaceutici Italia SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1962-06-11

Filing date

1963-06-10

Publication date

1963-12-16

1963-06-10 Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA

1963-12-16 Publication of ES288887A1 publication Critical patent/ES288887A1/es

Status Expired legal-status Critical Current

Links

UNELDXFWWQRODL-IUODEOHRSA-N (6ar,10ar)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline Chemical compound C1=CC([C@H]2CCCN([C@@H]2C2)C)=C3C2=CN(C)C3=C1 UNELDXFWWQRODL-IUODEOHRSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000001735 carboxylic acids Chemical class 0.000 abstract 2
-1 cycloaliphatic Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000000075 primary alcohol group Chemical group 0.000 abstract 1
150000003568 thioethers Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES288887A 1962-06-11 1963-06-10 Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-ergolina Expired ES288887A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1167062		1962-06-11

Publications (1)

Publication Number	Publication Date
ES288887A1 true ES288887A1 (es)	1963-12-16

Family

ID=11136772

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES288887A Expired ES288887A1 (es)	1962-06-11	1963-06-10	Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-ergolina

Country Status (8)

Country	Link
US (1)	US3228943A (es)
AT (1)	AT258481B (es)
BR (1)	BR6349779D0 (es)
CH (1)	CH446367A (es)
DK (1)	DK103780C (es)
ES (1)	ES288887A1 (es)
GB (1)	GB981827A (es)
SE (1)	SE315904B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3879554A (en) *	1970-03-20	1975-04-22	Farmaceutici Italia	Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
NL159384B (nl) *	1971-03-13	1979-02-15	Farmaceutici Italia	Werkwijze voor het bereiden van een geneesmiddel met een adrenolytische activiteit, alsmede werkwijze voor het bereiden van een ester van 1-methyl-10-methoxylumilysergol.
DE2330912C3 (de) *	1972-06-22	1979-01-11	Societa Farmaceutici Italia S.P.A., Mailand (Italien)	Verfahren zur Herstellung von Bromergolinverbindungen
NL7400790A (es) *	1973-02-02	1974-08-06
US3996228A (en) *	1973-12-21	1976-12-07	Societa' Farmaceutici Italia S.P.A.	Pyrimidinoaminoethyl ergoline derivatives
US3929796A (en) *	1974-08-02	1975-12-30	Lilly Co Eli	Synthesis of penniclavine and elymoclavine
US4199579A (en) *	1975-03-14	1980-04-22	Siphar S. A.	Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof
US4054567A (en) *	1975-08-11	1977-10-18	Eli Lilly And Company	6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
US4082753A (en) *	1976-02-17	1978-04-04	Eli Lilly And Company	Penniclavine acetonide
YU40004B (en) *	1977-07-21	1985-06-30	Lek Tovarna Farmacevtskih	Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid
IT1094965B (it) *	1978-04-05	1985-08-10	Corvi Mora E	Procedimento di preparazione di derivati del lisergolo
US4382940A (en) *	1979-12-06	1983-05-10	Farmitalia Carlo Erba S.P.A.	Ercoline derivatives and therapeutic compositions having CNS affecting activity
IT1173489B (it) *	1984-03-27	1987-06-24	Inverni Della Beffa Spa	Procedimento di preparazione di 1-metil-10alfa-metossilumilisergolo e di suci esteri,e intermedi per la loro preparazione
IT1213206B (it) *	1984-08-07	1989-12-14	Inverni Della Beffa Spa	Procedimento per la preparazione di derivati del lisergolo.
HU193782B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
FR2584720B1 (fr) *	1985-07-11	1987-10-02	Rhone Poulenc Sante	Procede de preparation de derives n-methyles de l'ergoline
FR2584721B1 (fr) *	1985-07-11	1987-10-02	Rhone Poulenc Sante	Procede de preparation des derives n-methyles du dihydrolysergate de methyle ou du methoxylumilysergate de methyle
FR2584719B1 (fr) *	1985-07-11	1987-10-02	Rhone Poulenc Sante	Procede de preparation des derives n-methyles du lysergol et du methoxy-10a lumilysergol
US4713385A (en) *	1985-10-01	1987-12-15	Eli Lilly And Company	Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists
US4683237A (en) *	1985-12-20	1987-07-28	Eli Lilly And Company	Fluoroalkyl esters of dihydrolysergic acid useful as 5HT2 receptor antagonists
US5211504A (en) *	1991-01-31	1993-05-18	Roger Trudel	Adjustable manhole top
FR2786101B1 (fr)	1998-11-24	2002-07-05	Aventis Laboratoire	Utilisation de la nicergoline dans le traitement de la spasticite
FR2786100B1 (fr)	1998-11-24	2002-03-01	Aventis Laboratoire	Nouvelle application therapeutique de la nicergoline
AU2003250483A1 (en)	2002-08-19	2004-03-11	Pfizer Products Inc.	Combination therapy for hyperproliferative diseases
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
US20060063803A1 (en) *	2004-09-23	2006-03-23	Pfizer Inc	4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
EP2986599A1 (en)	2013-04-17	2016-02-24	Pfizer Inc.	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
BR112021013807A2 (pt)	2019-01-18	2021-11-30	Astrazeneca Ab	Inibidores de pcsk9 e seus métodos de uso

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3155667A (en) *		1964-11-03		Process for the preparation of
GB786138A (en) *	1955-02-04	1957-11-13	Sandoz Ltd	New ergot alkaloid derivatives and process of making same

1963
- 1963-06-04 US US28522963 patent/US3228943A/en not_active Expired - Lifetime
- 1963-06-06 GB GB22576/63A patent/GB981827A/en not_active Expired
- 1963-06-07 DK DK270863AA patent/DK103780C/da active
- 1963-06-07 AT AT461263A patent/AT258481B/de active
- 1963-06-07 SE SE6306/63A patent/SE315904B/xx unknown
- 1963-06-10 CH CH723163A patent/CH446367A/de unknown
- 1963-06-10 ES ES288887A patent/ES288887A1/es not_active Expired
- 1963-06-10 BR BR149779/63A patent/BR6349779D0/pt unknown

Also Published As

Publication number	Publication date
US3228943A (en)	1966-01-11
DK103780C (da)	1966-02-21
DE1470241A1 (de)	1969-12-11
SE315904B (es)	1969-10-13
AT258481B (de)	1967-11-27
GB981827A (en)	1965-01-27
BR6349779D0 (pt)	1973-07-03
CH446367A (de)	1967-11-15

Publication	Publication Date	Title
ES288887A1 (es)	1963-12-16	Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-ergolina
GB1111988A (en)	1968-05-01	2',3'-dideoxyriboside-2',3'-olefins
ES343513A1 (es)	1968-10-16	Un procedimiento para la preparacion de 1,6-dimetil-10 alfa-ergolina.
ES288826A1 (es)	1963-11-16	Procedimiento para la preparación de nuevos derivados lumiergolínicos
ES289117A1 (es)	1963-12-16	Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-8-amino-metil-ergolina i
ES290275A2 (es)	1964-03-01	Procedimiento para preparar nuevos compuestos de la 6-metil y la 1,6-dimetil-er-golina ii
ES266945A1 (es)	1961-11-01	Procedimiento de obtenciën de derivados de tiaxanteno
GB992961A (en)	1965-05-26	Process for the manufacture of amino acid derivatives
ES289046A1 (es)	1963-12-16	Un procedimiento para preparar nuevos derivados de la 6-metil y la 1,6-dimetil-8-(alfa-hidroxi-alquil)-ergolina i
GB560081A (en)	1944-03-20	A process for the manufacture of new unsaturated alcohols
ES292328A1 (es)	1963-12-01	Procedimiento de preparación de derivados colchícicos
ES282859A1 (es)	1963-07-01	Un procedimiento para la preparación de derivados de 6-metil y 1,6-dimetil-ergolina ii
GB752033A (en)	1956-07-04	Steroids
GB1219848A (en)	1971-01-20	NOVEL N-SUBSTITUTED-o-PHENYLENE AMINES, AND PROCESSES FOR THEIR PREPARATION
ES313421A1 (es)	1966-02-01	Un procedimiento de preparaciën de derivados esteroides trienicos
ES270019A1 (es)	1962-05-01	Procedimiento de obtenciën de nuevos compuestos 2,3-dihidro de la serie de los acidos lisergico y dihidrolisergico
ES343931A1 (es)	1968-10-16	Procedimiento para preparar un decapeptido y sus sales.
GB761615A (en)	1956-11-14	Improvements in or relating to lysergic acid derivatives
GB911489A (en)	1962-11-28	Serine derivative
ES364709A1 (es)	1970-12-16	Procedimiento para la preparacion de nuevos derivados de sulfanilamida.
ES272550A1 (es)	1962-02-16	Procedimiento de preparacion de un nuevo derivado de la fenotiacina
ES380392A1 (es)	1973-01-16	Procedimiento para la preparacion de un compuesto de 5-ni- tro-furil-pirazol.
ES354698A1 (es)	1970-02-16	Un procedimiento de preparacion de las amidas del acido eu-genico o acido 2-hidroxi-3-metoxi-5-alil - benzoico, de sus esteres y de sus eteres.
ES265558A1 (es)	1961-05-16	Procedimiento para la preparacion de derivados de 1-metil-estratieno
GB856361A (en)	1960-12-14	4-methyl-17ª-hydroxyprogesterone and its esters and their preparation