ES290000A1 - Procedure for the preparation of carboxylic acid piperazides (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of carboxylic acid piperazides (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES290000A1 ES290000A1 ES0290000A ES290000A ES290000A1 ES 290000 A1 ES290000 A1 ES 290000A1 ES 0290000 A ES0290000 A ES 0290000A ES 290000 A ES290000 A ES 290000A ES 290000 A1 ES290000 A1 ES 290000A1
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- molecular weight
- low molecular
- phenyl
- halogen atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001735 carboxylic acids Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 2-phenyl-vinyl group Chemical group 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for the preparation of piperazides of carboxylic acids of the general formula I ** (See formula) ** where R represents the remains of the general formulas II or III ** (See formula) ** in which R2 represents hydrogen or a phenyl radical optionally substituted by a halogen atom, R3 and R4 represent in each case phenyl radicals optionally substituted by one or more halogen atoms or benzyl radicals optionally substituted in alpha position by low molecular weight alkyl , and together, represent a benzylidene residue optionally substituted by one or more halogen atoms, R5 and R6 represent in each case a phenyl residue optionally substituted one or more times by halogen atoms, low molecular weight alkyl, low molecular weight alkoxy optionally substituted phenyl groups and/or optionally substituted phenoxy groups and R7 represents a methyl group or a 2-phenyl-vinyl group optionally substituted in the benzene nucleus by one or more halogen atoms, by low molecular weight alkyl groups and/or by low molecular weight alkoxy groups, and represents hydrogen, an alkyl, cycloalkyl or phenylalkoyl group or of low molecular weight optionally substituted one or more times, and n is 0 or 1, characterized in that a carboxylic acid of the general formula IV is reacted in a manner known per se. R - COOH wherein R has the above meaning, or a reactive derivative thereof, with a piperazine of the general formula V ** (See formula) ** in which R1 has the above-mentioned significance, optionally it is catalytically hydrogenated and/or subsequently alkylated, and the process products obtained are optionally converted with physiologically acceptable acids into corresponding salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE290000X | 1962-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES290000A1 true ES290000A1 (en) | 1964-03-01 |
Family
ID=38570352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0290000A Expired ES290000A1 (en) | 1962-12-21 | 1963-07-15 | Procedure for the preparation of carboxylic acid piperazides (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES290000A1 (en) |
-
1963
- 1963-07-15 ES ES0290000A patent/ES290000A1/en not_active Expired
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