ES2911226T3 - Mejoras en los dispositivos de bolo para el suministro de principios activos en animales - Google Patents
Mejoras en los dispositivos de bolo para el suministro de principios activos en animales Download PDFInfo
- Publication number
- ES2911226T3 ES2911226T3 ES09829371T ES09829371T ES2911226T3 ES 2911226 T3 ES2911226 T3 ES 2911226T3 ES 09829371 T ES09829371 T ES 09829371T ES 09829371 T ES09829371 T ES 09829371T ES 2911226 T3 ES2911226 T3 ES 2911226T3
- Authority
- ES
- Spain
- Prior art keywords
- active
- tablets
- bolus
- tablet
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241001465754 Metazoa Species 0.000 title claims abstract description 53
- 239000004480 active ingredient Substances 0.000 title claims description 9
- 239000013543 active substance Substances 0.000 claims abstract description 17
- 230000000507 anthelmentic effect Effects 0.000 claims description 4
- 241000282849 Ruminantia Species 0.000 claims description 3
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 14
- 230000015556 catabolic process Effects 0.000 description 10
- 238000006731 degradation reaction Methods 0.000 description 10
- 241000283690 Bos taurus Species 0.000 description 9
- 239000000203 mixture Substances 0.000 description 7
- 229910002804 graphite Inorganic materials 0.000 description 6
- 239000010439 graphite Substances 0.000 description 6
- 244000045947 parasite Species 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- 244000309466 calf Species 0.000 description 4
- 210000004767 rumen Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 description 3
- 239000005660 Abamectin Substances 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 229950008167 abamectin Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 230000001568 sexual effect Effects 0.000 description 3
- 206010061217 Infestation Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000003071 parasitic effect Effects 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 description 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 description 1
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 description 1
- LAZPBGZRMVRFKY-HNCPQSOCSA-N Levamisole hydrochloride Chemical compound Cl.C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 LAZPBGZRMVRFKY-HNCPQSOCSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229940124339 anthelmintic agent Drugs 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229960002418 ivermectin Drugs 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 229960001614 levamisole Drugs 0.000 description 1
- 229960003734 levamisole hydrochloride Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ573143A NZ573143A (en) | 2008-11-25 | 2008-11-25 | Improvements in delivery devices |
| PCT/NZ2009/000129 WO2010062190A1 (en) | 2008-11-25 | 2009-06-29 | Improvements in bolus devices for the delivery of active agents to animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2911226T3 true ES2911226T3 (es) | 2022-05-18 |
Family
ID=42040796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09829371T Active ES2911226T3 (es) | 2008-11-25 | 2009-06-29 | Mejoras en los dispositivos de bolo para el suministro de principios activos en animales |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8329206B2 (pt) |
| EP (2) | EP2361053B1 (pt) |
| AU (2) | AU2009320500B2 (pt) |
| BR (1) | BRPI0921187A2 (pt) |
| ES (1) | ES2911226T3 (pt) |
| NZ (1) | NZ573143A (pt) |
| WO (2) | WO2010062190A1 (pt) |
| ZA (2) | ZA201104723B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103126886A (zh) * | 2011-05-13 | 2013-06-05 | 中国农业科学院北京畜牧兽医研究所 | 一种仔猪安抚剂释放盒 |
| US11529310B2 (en) | 2020-12-08 | 2022-12-20 | Ruminant Biotech Corp Limited | Devices and methods for delivery of substances to animals |
| AT528167A1 (de) | 2024-03-15 | 2025-10-15 | Smaxtec Animal Care Gmbh | Sondenvorrichtung mit zumindest einer Reservoir-Einheit |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2416467A1 (fr) * | 1978-02-03 | 1979-08-31 | Ici Ltd | Procede et appareil pour l'analyse de gaz |
| US4418686A (en) * | 1979-08-01 | 1983-12-06 | Child Laboratories Inc. | Implant for inhibiting mastitis in dairy cattle |
| US4381780A (en) | 1981-01-19 | 1983-05-03 | Research Corporation | Sustained release delivery system |
| GR851195B (pt) * | 1984-06-02 | 1985-11-25 | Castex Prod | |
| GB8514666D0 (en) | 1985-06-11 | 1985-07-10 | Coopers Animal Health | Agent delivery systems |
| AU605482B2 (en) * | 1986-04-17 | 1991-01-17 | Castex Products Limited | Pellet for administration to ruminants |
| US5219572A (en) * | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
| GB9023270D0 (en) * | 1990-10-25 | 1990-12-05 | Castex Prod | Magnesium manganese alloy |
| US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
| DK0739198T3 (da) * | 1994-01-20 | 2004-01-26 | Agres Ltd | Anordning til indgivelse af gavnlige materialer til drøvtyggere |
| GB9801141D0 (en) * | 1998-01-21 | 1998-03-18 | Porter William L | Bolus for ruminent animals |
| US6030367A (en) * | 1999-03-22 | 2000-02-29 | Bracco Research | Plunger rod |
| GB0111391D0 (en) * | 2001-05-10 | 2001-07-04 | Porter William L | Pulse release bolus |
| NZ519363A (en) | 2002-06-05 | 2004-02-27 | Agres Ltd | A novel drug dosing regimen |
| CN1964748A (zh) * | 2004-04-06 | 2007-05-16 | 苏莫迪克斯公司 | 用于生物活性剂的涂料组合物 |
-
2008
- 2008-11-25 NZ NZ573143A patent/NZ573143A/en unknown
-
2009
- 2009-06-29 BR BRPI0921187A patent/BRPI0921187A2/pt not_active IP Right Cessation
- 2009-06-29 AU AU2009320500A patent/AU2009320500B2/en not_active Ceased
- 2009-06-29 US US13/131,259 patent/US8329206B2/en active Active
- 2009-06-29 WO PCT/NZ2009/000129 patent/WO2010062190A1/en not_active Ceased
- 2009-06-29 ES ES09829371T patent/ES2911226T3/es active Active
- 2009-06-29 EP EP09829371.5A patent/EP2361053B1/en active Active
- 2009-08-21 US US13/131,260 patent/US20110287081A1/en not_active Abandoned
- 2009-08-21 AU AU2009320501A patent/AU2009320501B2/en not_active Expired - Fee Related
- 2009-08-21 EP EP09829372.3A patent/EP2361055A4/en not_active Withdrawn
- 2009-08-21 WO PCT/NZ2009/000173 patent/WO2010062191A1/en not_active Ceased
-
2011
- 2011-06-24 ZA ZA2011/04723A patent/ZA201104723B/en unknown
- 2011-06-24 ZA ZA2011/04724A patent/ZA201104724B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010062191A1 (en) | 2010-06-03 |
| WO2010062190A1 (en) | 2010-06-03 |
| ZA201104723B (en) | 2012-12-27 |
| US20110280923A1 (en) | 2011-11-17 |
| EP2361053A1 (en) | 2011-08-31 |
| EP2361053A4 (en) | 2013-12-25 |
| EP2361053B1 (en) | 2022-01-19 |
| NZ573143A (en) | 2010-03-26 |
| AU2009320501A1 (en) | 2011-07-07 |
| EP2361055A4 (en) | 2013-12-18 |
| AU2009320500B2 (en) | 2014-09-25 |
| ZA201104724B (en) | 2012-12-27 |
| AU2009320501B2 (en) | 2014-08-21 |
| US20110287081A1 (en) | 2011-11-24 |
| US8329206B2 (en) | 2012-12-11 |
| EP2361055A1 (en) | 2011-08-31 |
| BRPI0921187A2 (pt) | 2016-02-23 |
| AU2009320500A1 (en) | 2011-07-07 |
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