ES293218A1 - PROCEDURE FOR THE MANUFACTURE OF MEDIA OF RADIOLOGICAL CONSTRASTE - Google Patents

PROCEDURE FOR THE MANUFACTURE OF MEDIA OF RADIOLOGICAL CONSTRASTE

Info

Publication number
ES293218A1
ES293218A1 ES293218A ES293218A ES293218A1 ES 293218 A1 ES293218 A1 ES 293218A1 ES 293218 A ES293218 A ES 293218A ES 293218 A ES293218 A ES 293218A ES 293218 A1 ES293218 A1 ES 293218A1
Authority
ES
Spain
Prior art keywords
manufacture
media
procedure
radiological
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES293218A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Eprova AG
Original Assignee
Eprova AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1378862A external-priority patent/CH414063A/en
Application filed by Eprova AG filed Critical Eprova AG
Publication of ES293218A1 publication Critical patent/ES293218A1/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452Solutions, e.g. for injection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461Dispersions, colloids, emulsions or suspensions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)

Abstract

Procedure for the manufacture of radiological contrast media, characterized in that for the manufacture of 3 - (α -cylamino) -alkyl-5-acylamino-2,4,6, -triyodobenzoic acids, used as components of the radiological contrast media, of the general formula ** (See formula) ** wherein R-CO- and R'-CO- represent lower aliphatic acyl groups and R ", preferably hydrogen or a lower alkyl group, such as the methyl group, or of their esters with lower alcohols - (α -amino) -alkyl-5-amino-benzoics, their 3-monoacyl derivatives or derivatives transformed into the carboxyl group of said acids, are treated with iodination media, and then the compounds of 2.4 are acylated , 6-triyode obtained. (Machine-translation by Google Translate, not legally binding)
ES293218A 1962-11-23 1963-11-05 PROCEDURE FOR THE MANUFACTURE OF MEDIA OF RADIOLOGICAL CONSTRASTE Expired ES293218A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1378862A CH414063A (en) 1962-11-23 1962-11-23 X-ray contrast media
CH985763A CH435563A (en) 1962-11-23 1963-08-09 X-ray contrast media

Publications (1)

Publication Number Publication Date
ES293218A1 true ES293218A1 (en) 1964-01-16

Family

ID=25705437

Family Applications (1)

Application Number Title Priority Date Filing Date
ES293218A Expired ES293218A1 (en) 1962-11-23 1963-11-05 PROCEDURE FOR THE MANUFACTURE OF MEDIA OF RADIOLOGICAL CONSTRASTE

Country Status (12)

Country Link
AT (1) AT249263B (en)
BE (1) BE640222A (en)
BR (1) BR6354529D0 (en)
CH (1) CH435563A (en)
DE (1) DE1273747B (en)
DK (1) DK107965C (en)
ES (1) ES293218A1 (en)
FI (1) FI42984C (en)
FR (1) FR3449M (en)
GB (1) GB1002344A (en)
NL (2) NL300867A (en)
SE (2) SE316870B (en)

Also Published As

Publication number Publication date
AT249263B (en) 1966-09-12
FI42984B (en) 1970-09-02
FI42984C (en) 1970-12-10
NL300867A (en) 1965-09-27
FR3449M (en) 1965-07-26
DK107965C (en) 1967-07-24
BE640222A (en) 1964-05-20
SE327193B (en) 1970-08-17
SE316870B (en) 1969-11-03
GB1002344A (en) 1965-08-25
CH435563A (en) 1967-05-15
NL130868C (en) 1971-03-15
BR6354529D0 (en) 1973-02-22
DE1273747B (en) 1968-07-25

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