ES293384A1 - A procedure for preparing derivatives of colchicine and tiocolchicine (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for preparing derivatives of colchicine and tiocolchicine (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES293384A1 ES293384A1 ES0293384A ES293384A ES293384A1 ES 293384 A1 ES293384 A1 ES 293384A1 ES 0293384 A ES0293384 A ES 0293384A ES 293384 A ES293384 A ES 293384A ES 293384 A1 ES293384 A1 ES 293384A1
- Authority
- ES
- Spain
- Prior art keywords
- colchicine
- translation
- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- -1 alkyl radical Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- CMEGANPVAXDBPL-INIZCTEOSA-N n-[(7s)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC CMEGANPVAXDBPL-INIZCTEOSA-N 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229960001338 colchicine Drugs 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical class 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
- A01N45/02—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring having three carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A process for the preparation of colchicine and thiocolchicine derivatives of the general formula: ** (See formula) ** in which Y represents hydrogen or a radical (see formula) R1 and R2, which are the same or different, represent hydrogen, a lower alkyl radical, aryl or aralkyl, represents hydrogen or an acyl radical, and Z a -O-alkyl, or an -S-alkyl, and their salts of quaternary ammonium, and among these compounds especially 1-dimethyl-aminomethyl-2-demethylcolchicine and its salts, such as methoiodide and 1-dimethyl-aminomethyl-2-demethylthiocolchicine and their salts, such as methoiodide, characterized in that it is react with formaldehyde, in the presence of ammonia or a primary amine or secondary derivative of colchicine or thiocolchicine of the general formula: ** (See formula) ** conserving Y and Z the cited meanings, the derivative is obtained (see formula) corresponding, and it is transformed, if necessary, into quaternary ammonium salt or a corresponding 2-acylated compound. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR915142A FR1347137A (en) | 1962-11-12 | 1962-11-12 | New derivatives of colchicine and thiocolchicine and method of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES293384A1 true ES293384A1 (en) | 1964-01-01 |
Family
ID=8790618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0293384A Expired ES293384A1 (en) | 1962-11-12 | 1963-11-11 | A procedure for preparing derivatives of colchicine and tiocolchicine (Machine-translation by Google Translate, not legally binding) |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT241031B (en) |
| CH (1) | CH444144A (en) |
| ES (1) | ES293384A1 (en) |
| FR (1) | FR1347137A (en) |
-
1962
- 1962-11-12 FR FR915142A patent/FR1347137A/en not_active Expired
-
1963
- 1963-11-07 CH CH1367563A patent/CH444144A/en unknown
- 1963-11-11 ES ES0293384A patent/ES293384A1/en not_active Expired
- 1963-11-12 AT AT903563A patent/AT241031B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| AT241031B (en) | 1965-06-25 |
| FR1347137A (en) | 1963-12-27 |
| CH444144A (en) | 1967-09-30 |
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