ES2934341T3 - Combinaciones de inhibidores de FGFR4 y secuestrantes de ácidos biliares - Google Patents

Combinaciones de inhibidores de FGFR4 y secuestrantes de ácidos biliares Download PDF

Info

Publication number: ES2934341T3
Authority: ES; Spain
Prior art keywords: alkyl; carboxamide; methyl; fgfr4; bile acid
Prior art date: 2016-11-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES17812269T

Other languages

English (en)

Spanish (es)

Inventor

Robin Alec Fairhurst

Porta Diana Graus

Jacqueline Kinyamu-Akunda

Andreas Joerg Mahl

Luigi Manenti

Andreas Weiss

Armin Wolf

Kuno Wuersch

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-11-02

Filing date

2017-11-01

Publication date

2023-02-21

2017-11-01 Application filed by Novartis AG filed Critical Novartis AG

2023-02-21 Application granted granted Critical

2023-02-21 Publication of ES2934341T3 publication Critical patent/ES2934341T3/es

Status Active legal-status Critical Current

2037-11-01 Anticipated expiration legal-status Critical

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/785—Polymers containing nitrogen
- A—HUMAN NECESSITIES
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Animal Behavior & Ethology (AREA)
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Public Health (AREA)
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Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES17812269T 2016-11-02 2017-11-01 Combinaciones de inhibidores de FGFR4 y secuestrantes de ácidos biliares Active ES2934341T3 (es)

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US201662416222P	2016-11-02	2016-11-02
PCT/IB2017/056787 WO2018083603A1 (fr)	2016-11-02	2017-11-01	Combinaisons d'inhibiteurs de fgfr4 et de chélateurs de l'acide biliaire

Publications (1)

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ES17812269T Active ES2934341T3 (es)	2016-11-02	2017-11-01	Combinaciones de inhibidores de FGFR4 y secuestrantes de ácidos biliares

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US (1)	US11229643B2 (fr)
EP (1)	EP3534902B1 (fr)
JP (2)	JP7394623B2 (fr)
KR (1)	KR102362648B1 (fr)
CN (2)	CN109922804B (fr)
AU (1)	AU2017354082B2 (fr)
CA (1)	CA3042475C (fr)
ES (1)	ES2934341T3 (fr)
IL (1)	IL266293B (fr)
MA (1)	MA46712A (fr)
MX (1)	MX387222B (fr)
PL (1)	PL3534902T3 (fr)
PT (1)	PT3534902T (fr)
RU (1)	RU2742033C2 (fr)
SG (1)	SG11201903911UA (fr)
WO (1)	WO2018083603A1 (fr)
ZA (1)	ZA201902744B (fr)

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CN112759593A (zh) *	2019-11-01	2021-05-07	北京伯汇生物技术有限公司	桥环并醛基吡啶衍生物及其应用

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MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016151501A1 (fr) *	2015-03-25	2016-09-29	Novartis Ag	Combinaisons pharmaceutiques
EP3095465A1 (fr) *	2015-05-19	2016-11-23	U3 Pharma GmbH	Combinaison d'un inhibiteur de fgfr4 et d'un chélateur d'acides biliaires

2017
- 2017-11-01 JP JP2019523704A patent/JP7394623B2/ja active Active
- 2017-11-01 PT PT178122693T patent/PT3534902T/pt unknown
- 2017-11-01 MX MX2019005194A patent/MX387222B/es unknown
- 2017-11-01 US US16/347,194 patent/US11229643B2/en active Active
- 2017-11-01 IL IL266293A patent/IL266293B/en unknown
- 2017-11-01 AU AU2017354082A patent/AU2017354082B2/en active Active
- 2017-11-01 ES ES17812269T patent/ES2934341T3/es active Active
- 2017-11-01 EP EP17812269.3A patent/EP3534902B1/fr active Active
- 2017-11-01 RU RU2019116061A patent/RU2742033C2/ru active
- 2017-11-01 MA MA046712A patent/MA46712A/fr unknown
- 2017-11-01 CN CN201780068265.7A patent/CN109922804B/zh active Active
- 2017-11-01 CN CN202311453574.XA patent/CN117257800A/zh active Pending
- 2017-11-01 WO PCT/IB2017/056787 patent/WO2018083603A1/fr not_active Ceased
- 2017-11-01 PL PL17812269.3T patent/PL3534902T3/pl unknown
- 2017-11-01 SG SG11201903911UA patent/SG11201903911UA/en unknown
- 2017-11-01 KR KR1020197015424A patent/KR102362648B1/ko active Active
- 2017-11-01 CA CA3042475A patent/CA3042475C/fr active Active
2019
- 2019-05-02 ZA ZA2019/02744A patent/ZA201902744B/en unknown
2021
- 2021-11-10 JP JP2021183688A patent/JP7868965B2/ja active Active

Also Published As

Publication number	Publication date
WO2018083603A1 (fr)	2018-05-11
MX387222B (es)	2025-03-18
IL266293B (en)	2022-07-01
EP3534902B1 (fr)	2022-11-23
JP2022033766A (ja)	2022-03-02
AU2017354082B2 (en)	2023-07-27
CA3042475C (fr)	2024-01-16
JP7868965B2 (ja)	2026-06-02
RU2019116061A (ru)	2020-12-04
US20200261444A1 (en)	2020-08-20
PL3534902T3 (pl)	2023-03-27
SG11201903911UA (en)	2019-05-30
AU2017354082A1 (en)	2019-05-23
KR20190082256A (ko)	2019-07-09
ZA201902744B (en)	2021-08-25
CA3042475A1 (fr)	2018-05-11
IL266293A (en)	2019-06-30
EP3534902A1 (fr)	2019-09-11
CN109922804A (zh)	2019-06-21
MX2019005194A (es)	2019-08-05
US11229643B2 (en)	2022-01-25
PT3534902T (pt)	2022-12-07
BR112019008787A2 (pt)	2019-07-16
RU2742033C2 (ru)	2021-02-01
MA46712A (fr)	2019-09-11
RU2019116061A3 (fr)	2020-12-04
CN109922804B (zh)	2023-11-17
JP2019533701A (ja)	2019-11-21
JP7394623B2 (ja)	2023-12-08
CN117257800A (zh)	2023-12-22
KR102362648B1 (ko)	2022-02-11

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US20210251944A1 (en)	2021-08-19	Methods for treating a cancer resistant to at least one tyrosine kinase inhibitor
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CA2914025C (fr)	2023-03-07	Utilisation de dianhydrogalacticol et d'analogues et de derives de celui-ci pour traiter un gliome malin recurrent ou une tumeur cerebrale secondaire progressive
Zhuang et al.	2012	Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model
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JP2020512977A (ja)	2020-04-30	Ｃｈｋ１阻害剤とｗｅｅ１阻害剤との組み合わせ
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HK40105125A (en)	2024-08-09	Combinations of fgfr4 inhibitors and bile acid sequestrants
HK40009437B (en)	2024-05-10	Combinations of fgfr4 inhibitors and bile acid sequestrants
HK40009437A (en)	2020-06-26	Combinations of fgfr4 inhibitors and bile acid sequestrants