ES2948324A8 - Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol monohidrato (Estetrol monohidrato) - Google Patents
Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol monohidrato (Estetrol monohidrato)Info
- Publication number
- ES2948324A8 ES2948324A8 ES202330269A ES202330269A ES2948324A8 ES 2948324 A8 ES2948324 A8 ES 2948324A8 ES 202330269 A ES202330269 A ES 202330269A ES 202330269 A ES202330269 A ES 202330269A ES 2948324 A8 ES2948324 A8 ES 2948324A8
- Authority
- ES
- Spain
- Prior art keywords
- monohydrate
- 15alpha
- 16alpha
- 17beta
- estra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0007—Androstane derivatives not substituted in position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000017414A IT201900017414A1 (it) | 2019-09-27 | 2019-09-27 | Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo |
| IT102019000021879A IT201900021879A1 (it) | 2019-11-22 | 2019-11-22 | PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| ES2948324A2 ES2948324A2 (es) | 2023-09-08 |
| ES2948324A9 ES2948324A9 (es) | 2025-07-16 |
| ES2948324A8 true ES2948324A8 (es) | 2025-08-11 |
| ES2948324R1 ES2948324R1 (es) | 2025-09-11 |
Family
ID=72895895
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES202290021A Active ES2915058B2 (es) | 2019-09-27 | 2020-09-25 | Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho proceso |
| ES202330269A Pending ES2948324R1 (es) | 2019-09-27 | 2020-09-25 | Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol monohidrato (Estetrol monohidrato) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES202290021A Active ES2915058B2 (es) | 2019-09-27 | 2020-09-25 | Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho proceso |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20220348607A1 (es) |
| JP (1) | JP7588140B2 (es) |
| CN (2) | CN116355031A (es) |
| AU (2) | AU2020355615B2 (es) |
| BR (1) | BR112022005359A2 (es) |
| CA (1) | CA3151465C (es) |
| CH (2) | CH718008B1 (es) |
| DE (1) | DE112020004564T5 (es) |
| ES (2) | ES2915058B2 (es) |
| FR (2) | FR3101348B1 (es) |
| GB (2) | GB2617040B (es) |
| MX (2) | MX2022003688A (es) |
| TR (1) | TR2023003649A2 (es) |
| UY (2) | UY38895A (es) |
| WO (1) | WO2021058716A1 (es) |
| ZA (2) | ZA202204137B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
| DE112021008305T5 (de) * | 2021-10-01 | 2024-07-25 | Industriale Chimica S.R.L. | VERFAHREN ZUR HERSTELLUNG VON (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) UND ESTETROL-MONOHYDRAT |
| HUP2500316A1 (en) * | 2023-02-02 | 2025-11-28 | Ind Chimica Srl | Process for preparing (15alpha,16alpha,17beta)-estra-1,3,5(10)-triene-3,15,16,17-tetrol (estetrol) monohydrate |
| CN117088928B (zh) * | 2023-08-16 | 2025-09-09 | 湖北共同甾体药物研究院有限公司 | 用于制备高纯度雌四醇的工艺 |
| CN119569803B (zh) * | 2023-09-05 | 2025-09-16 | 秦皇岛紫竹药业有限公司 | 一种制备高纯度雌四醇的方法 |
| HUP2400151A1 (hu) | 2024-02-28 | 2025-09-28 | Richter Gedeon Nyrt | Ösztetrol-monohidrát kristályosítási eljárás |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002100877A1 (en) * | 2001-06-11 | 2002-12-19 | Southwest Foundation For Biomedical Research | Novel 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity |
| AU2003279624A1 (en) * | 2002-11-08 | 2004-06-07 | Pantarhei Bioscience B.V. | Synthesis of estetrol via estrone derived steroids |
| CN101177441B (zh) * | 2007-12-05 | 2012-05-23 | 浙江耐司康药业有限公司 | 一种稳定的阿奇霉素一水合物结晶的制备方法 |
| CN103703014A (zh) | 2011-06-01 | 2014-04-02 | 埃斯特拉公司 | 用于产生雌四醇中间体的方法 |
| EP2383279A1 (en) * | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| HRP20161282T1 (hr) | 2011-10-07 | 2016-11-18 | Estetra S.P.R.L. | Postupak za proizvodnju estetrola |
| WO2013034780A2 (en) * | 2012-12-20 | 2013-03-14 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol and related compounds |
| US9988417B2 (en) | 2013-09-18 | 2018-06-05 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol |
| JP6447931B2 (ja) * | 2013-12-12 | 2019-01-09 | ドネスタ バイオサイエンス ビー．ブイ．Ｄｏｎｅｓｔａ Ｂｉｏｓｃｉｅｎｃｅ Ｂ．Ｖ． | エステトロール成分を含有する口腔内崩壊固体単位剤形 |
| JP6813150B2 (ja) * | 2015-06-18 | 2021-01-13 | エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ | エステトロールを含有する口腔内崩壊錠 |
| AU2018447005B2 (en) * | 2018-10-26 | 2022-03-17 | Howmet Aerospace Inc. | Vehicle wheel and methods of making and using a vehicle wheel |
| HU231240B1 (hu) * | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
-
2020
- 2020-09-25 BR BR112022005359A patent/BR112022005359A2/pt unknown
- 2020-09-25 US US17/763,267 patent/US20220348607A1/en active Pending
- 2020-09-25 DE DE112020004564.1T patent/DE112020004564T5/de active Pending
- 2020-09-25 UY UY0001038895A patent/UY38895A/es unknown
- 2020-09-25 CN CN202310346726.XA patent/CN116355031A/zh active Pending
- 2020-09-25 CH CH000332/2022A patent/CH718008B1/it unknown
- 2020-09-25 TR TR2023/003649A patent/TR2023003649A2/tr unknown
- 2020-09-25 CN CN202080065426.9A patent/CN114514237B/zh active Active
- 2020-09-25 GB GB2310271.8A patent/GB2617040B/en active Active
- 2020-09-25 ES ES202290021A patent/ES2915058B2/es active Active
- 2020-09-25 CA CA3151465A patent/CA3151465C/en active Active
- 2020-09-25 AU AU2020355615A patent/AU2020355615B2/en active Active
- 2020-09-25 CH CH000356/2023A patent/CH721078B1/it unknown
- 2020-09-25 UY UY0001040209A patent/UY40209A/es unknown
- 2020-09-25 FR FR2009758A patent/FR3101348B1/fr active Active
- 2020-09-25 GB GB2205967.9A patent/GB2603868B/en active Active
- 2020-09-25 JP JP2022515787A patent/JP7588140B2/ja active Active
- 2020-09-25 ES ES202330269A patent/ES2948324R1/es active Pending
- 2020-09-25 WO PCT/EP2020/076843 patent/WO2021058716A1/en not_active Ceased
- 2020-09-25 MX MX2022003688A patent/MX2022003688A/es unknown
-
2022
- 2022-03-25 MX MX2023004110A patent/MX2023004110A/es unknown
- 2022-04-12 ZA ZA2022/04137A patent/ZA202204137B/en unknown
-
2023
- 2023-02-24 FR FR2301733A patent/FR3132908A1/fr active Pending
- 2023-03-29 ZA ZA2023/03924A patent/ZA202303924B/en unknown
- 2023-04-12 AU AU2023202251A patent/AU2023202251B2/en active Active
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Legal Events
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| BA2A | Patent application published |
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