ES2948324A8 - Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol monohidrato (Estetrol monohidrato) - Google Patents

Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol monohidrato (Estetrol monohidrato)

Info

Publication number
ES2948324A8
ES2948324A8 ES202330269A ES202330269A ES2948324A8 ES 2948324 A8 ES2948324 A8 ES 2948324A8 ES 202330269 A ES202330269 A ES 202330269A ES 202330269 A ES202330269 A ES 202330269A ES 2948324 A8 ES2948324 A8 ES 2948324A8
Authority
ES
Spain
Prior art keywords
monohydrate
15alpha
16alpha
17beta
estra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES202330269A
Other languages
English (en)
Other versions
ES2948324R1 (es
ES2948324A2 (es
ES2948324A9 (es
Inventor
Roberto Lenna
Andrea Fasana
Riccardo Lucentini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industriale Chimica SRL
Original Assignee
Industriale Chimica SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT102019000017414A external-priority patent/IT201900017414A1/it
Priority claimed from IT102019000021879A external-priority patent/IT201900021879A1/it
Application filed by Industriale Chimica SRL filed Critical Industriale Chimica SRL
Publication of ES2948324A2 publication Critical patent/ES2948324A2/es
Publication of ES2948324A9 publication Critical patent/ES2948324A9/es
Publication of ES2948324A8 publication Critical patent/ES2948324A8/es
Publication of ES2948324R1 publication Critical patent/ES2948324R1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0007—Androstane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES202330269A 2019-09-27 2020-09-25 Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol monohidrato (Estetrol monohidrato) Pending ES2948324R1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102019000017414A IT201900017414A1 (it) 2019-09-27 2019-09-27 Processo per la preparazione di (15α,16α,17β)-estra-1,3,5(10)-triene-3,15,16,17-tetrolo (Estetrolo) ed intermedi di detto processo
IT102019000021879A IT201900021879A1 (it) 2019-11-22 2019-11-22 PROCESSO PER LA PREPARAZIONE DI (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROLO (ESTETROLO) ED INTERMEDI DI DETTO PROCESSO

Publications (4)

Publication Number Publication Date
ES2948324A2 ES2948324A2 (es) 2023-09-08
ES2948324A9 ES2948324A9 (es) 2025-07-16
ES2948324A8 true ES2948324A8 (es) 2025-08-11
ES2948324R1 ES2948324R1 (es) 2025-09-11

Family

ID=72895895

Family Applications (2)

Application Number Title Priority Date Filing Date
ES202330269A Pending ES2948324R1 (es) 2019-09-27 2020-09-25 Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol monohidrato (Estetrol monohidrato)
ES202290021A Active ES2915058B2 (es) 2019-09-27 2020-09-25 Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho proceso

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES202290021A Active ES2915058B2 (es) 2019-09-27 2020-09-25 Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho proceso

Country Status (16)

Country Link
US (1) US20220348607A1 (es)
JP (1) JP7588140B2 (es)
CN (2) CN116355031A (es)
AU (2) AU2020355615B2 (es)
BR (1) BR112022005359A2 (es)
CA (1) CA3151465C (es)
CH (2) CH718008B1 (es)
DE (1) DE112020004564T5 (es)
ES (2) ES2948324R1 (es)
FR (2) FR3101348B1 (es)
GB (2) GB2603868B (es)
MX (2) MX2022003688A (es)
TR (1) TR2023003649A2 (es)
UY (2) UY38895A (es)
WO (1) WO2021058716A1 (es)
ZA (2) ZA202204137B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU231240B1 (hu) * 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
DE112021008305T5 (de) * 2021-10-01 2024-07-25 Industriale Chimica S.R.L. VERFAHREN ZUR HERSTELLUNG VON (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) UND ESTETROL-MONOHYDRAT
AU2023428138A1 (en) * 2023-02-02 2025-09-04 Industriale Chimica S.R.L. PROCESS FOR PREPARING (15α,16α,17β)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL (ESTETROL) MONOHYDRATE
CN117088928B (zh) * 2023-08-16 2025-09-09 湖北共同甾体药物研究院有限公司 用于制备高纯度雌四醇的工艺
CN119569803B (zh) * 2023-09-05 2025-09-16 秦皇岛紫竹药业有限公司 一种制备高纯度雌四醇的方法
HUP2400151A1 (hu) 2024-02-28 2025-09-28 Richter Gedeon Nyrt Ösztetrol-monohidrát kristályosítási eljárás

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593321B2 (en) * 2001-06-11 2003-07-15 Southwest Foundation For Biomedical Research 2-alkoxyestradiol analogs with antiproliferative and antimitotic activity
AU2003279624A1 (en) * 2002-11-08 2004-06-07 Pantarhei Bioscience B.V. Synthesis of estetrol via estrone derived steroids
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
SG195118A1 (en) 2011-06-01 2013-12-30 Estetra S A Process for the production of estetrol intermediates
EP2383279A1 (en) * 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
RS55231B1 (sr) 2011-10-07 2017-02-28 Estetra Sprl Postupak proizvodnje estetrola
WO2013034780A2 (en) * 2012-12-20 2013-03-14 Crystal Pharma, S.A.U. Process for the preparation of estetrol and related compounds
EP3046928B1 (en) * 2013-09-18 2017-02-08 Crystal Pharma, S.A.U. Process for the preparation of estetrol
JP6447931B2 (ja) * 2013-12-12 2019-01-09 ドネスタ バイオサイエンス ビー．ブイ．Ｄｏｎｅｓｔａ Ｂｉｏｓｃｉｅｎｃｅ Ｂ．Ｖ． エステトロール成分を含有する口腔内崩壊固体単位剤形
LT3310346T (lt) * 2015-06-18 2021-06-10 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
MX2021004315A (es) * 2018-10-26 2021-05-27 Howmet Aerospace Inc Rueda de vehiculo y metodos de fabricacion y uso de una rueda de vehiculo.
HU231240B1 (hu) * 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására

Also Published As

Publication number Publication date
MX2022003688A (es) 2022-04-26
AU2020355615B2 (en) 2023-12-14
DE112020004564T5 (de) 2022-06-15
JP2022549585A (ja) 2022-11-28
AU2023202251A1 (en) 2023-05-04
ZA202303924B (en) 2025-03-26
FR3101348B1 (fr) 2024-01-19
ZA202204137B (en) 2023-06-28
AU2020355615A1 (en) 2022-05-19
US20220348607A1 (en) 2022-11-03
GB202205967D0 (en) 2022-06-08
CH718008B1 (it) 2024-01-31
FR3132908A1 (fr) 2023-08-25
CN114514237B (zh) 2024-07-26
CA3151465A1 (en) 2021-04-01
JP7588140B2 (ja) 2024-11-21
TR2023003649A2 (tr) 2024-01-22
UY40209A (es) 2023-06-15
GB2603868A (en) 2022-08-17
GB2617040A (en) 2023-09-27
FR3101348A1 (fr) 2021-04-02
CA3151465C (en) 2024-05-07
ES2915058B2 (es) 2024-06-21
ES2948324R1 (es) 2025-09-11
GB202310271D0 (en) 2023-08-16
MX2023004110A (es) 2023-04-27
GB2603868B (en) 2023-10-11
CH721078B1 (it) 2025-03-14
WO2021058716A1 (en) 2021-04-01
ES2915058A2 (es) 2022-06-20
ES2948324A2 (es) 2023-09-08
AU2023202251B2 (en) 2024-08-15
ES2915058R1 (es) 2023-12-11
CN114514237A (zh) 2022-05-17
CN116355031A (zh) 2023-06-30
GB2617040B (en) 2024-03-27
UY38895A (es) 2021-04-30
ES2948324A9 (es) 2025-07-16
BR112022005359A2 (pt) 2022-07-19

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