ES298096A1 - New piperazine derivatives - Google Patents

New piperazine derivatives

Info

Publication number
ES298096A1
ES298096A1 ES0298096A ES298096A ES298096A1 ES 298096 A1 ES298096 A1 ES 298096A1 ES 0298096 A ES0298096 A ES 0298096A ES 298096 A ES298096 A ES 298096A ES 298096 A1 ES298096 A1 ES 298096A1
Authority
ES
Spain
Prior art keywords
piperazine
bis
compound
compounds
pivaloyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0298096A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of ES298096A1 publication Critical patent/ES298096A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of general formula <FORM:1003349/C2/1> wherein each X independently represents chlorine, bromine, iodine or methanesulphonyloxy and their preparation (I) by reacting piperazine with two molecular equivalents of an appropriate pivaloyl chloride or with one molecular equivalent of two such pivaloyl chlorides in succession, (II) by halogenating or esterifying the compound where X is replaced by hydroxy. The interconversion of groups X generally is mentioned. 1,4 - Bis(acetyloxypivaloyl) piperazine is prepared from the dibromo-compound with silver acetate and is hydrolysed to 1,4-bis (hydroxypivaloyl) piperazine. Pharmaceutical compositions comprise compounds I with acceptable carriers or coatings. Forms (tablets, pills, powders, granules, syrups, elixirs, capsules, emulsions, solutions, suspensions) for oral and parenteral administration are described. The compounds act against sarcomas, carcinomas and leukaemias.
ES0298096A 1963-03-28 1964-03-28 New piperazine derivatives Expired ES298096A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR929571 1963-03-28

Publications (1)

Publication Number Publication Date
ES298096A1 true ES298096A1 (en) 1964-06-01

Family

ID=8800327

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0298096A Expired ES298096A1 (en) 1963-03-28 1964-03-28 New piperazine derivatives

Country Status (5)

Country Link
BE (1) BE645850A (en)
ES (1) ES298096A1 (en)
GB (1) GB1003349A (en)
NL (1) NL6403307A (en)
OA (1) OA00115A (en)

Also Published As

Publication number Publication date
GB1003349A (en) 1965-09-02
NL6403307A (en) 1964-09-29
BE645850A (en) 1964-09-28
OA00115A (en) 1966-01-15

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