ES299521A1 - Microtome cooling and dehumidifying - Google Patents
Microtome cooling and dehumidifyingInfo
- Publication number
- ES299521A1 ES299521A1 ES0299521A ES299521A ES299521A1 ES 299521 A1 ES299521 A1 ES 299521A1 ES 0299521 A ES0299521 A ES 0299521A ES 299521 A ES299521 A ES 299521A ES 299521 A1 ES299521 A1 ES 299521A1
- Authority
- ES
- Spain
- Prior art keywords
- liquid
- heat sink
- tube
- immersed
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001816 cooling Methods 0.000 title abstract 4
- 239000007788 liquid Substances 0.000 abstract 9
- 108010053481 Antifreeze Proteins Proteins 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 230000002528 anti-freeze Effects 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D17/00—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/283—With means to control or modify temperature of apparatus or work
Landscapes
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Combustion & Propulsion (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Apparatus for cooling a micistone having a specimen holder 15 and a knife 13 for cutting a specimen 15a comprises an air conduit adapted to receive the holder and knife and means for directing a stream of cooled, dried air through the conduit. The micistone is supported on a table 11 and enclosed in a cover 19 which is hingedly connected to the table. The cooling apparatus is a separate unit comprising a refrigerating system the evaporator 36 of which is immersed in a liquid heat sink 33. The air conduit 41 includes a portion 42 in the hinged cover 19, a portion 43 connecting the portion 42 with the top of the heat sink housing 34 and a cooling chamber 44. The cooled, dried air passes from the heat sink 33 through the portions 43, 42 onto the specimen 15a and subsequently into the chamber 44. Liquid, for example calcium chloride, is pumped from the heat sink 33 through a hollow tube 51 and sprayed into the chamber 44. A blower 58 mounted on the tube 51 draws air through an aperture 47 in a partition 46 of the chamber 44, and returns the air via apertures 50 to the heat sink 33. The sprayed liquid is allanges to flow into a drain-tube 62 having its exit immersed in the liquid in the heat sink. The volume of liquid in the sink 33 is controlled by a float-operated valve 67. When the valve is closed the liquid collected in the tube 62 passes via a tube 70 into a boiler 71. A device for storing specimens in frozen condition preparatory to cutting sections therefrom comprises a reservoir of anti-freeze liquid which is connected in a closed circuit with a coil immersed in the liquid of the heat sink 33, and a magnetically operated pump. The specimens are supported on members having extensions which are immersed in the liquid of the reservoir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27801463 US3236133A (en) | 1963-05-06 | 1963-05-06 | Microtome cooling and dehumidifying |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES299521A1 true ES299521A1 (en) | 1964-09-01 |
Family
ID=23063331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0299521A Expired ES299521A1 (en) | 1963-05-06 | 1964-05-05 | Microtome cooling and dehumidifying |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3236133A (en) |
| CH (1) | CH417142A (en) |
| ES (1) | ES299521A1 (en) |
| GB (1) | GB1059772A (en) |
| NL (1) | NL6404958A (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1170796A (en) * | 1967-02-17 | 1969-11-19 | Shandon Scient Ind Ltd | Improvements in or relating to Microtomes |
| US3803958A (en) * | 1969-06-02 | 1974-04-16 | Moran H Fernandez | Ultra thin sectioning with ultra sharp diamond edge at ultra low temperature |
| US3646841A (en) * | 1969-06-02 | 1972-03-07 | Humberto Fernandez Moran Villa | Apparatus using ultrasharp diamond edge for ultrathin sectioning |
| US3894208A (en) * | 1971-02-12 | 1975-07-08 | Wilfried Hellmuth Bergmann | Method of abrasive machining of material by means of an energy beam |
| GB1361334A (en) * | 1972-04-07 | 1974-07-24 | Imp Metal Ind Kynoch Ltd | Method and apparatus for cutting elongate articles |
| US4091580A (en) * | 1977-06-29 | 1978-05-30 | Timex Corporation | Process for holding and cutting sheet glass |
| DE8327637U1 (en) * | 1983-09-27 | 1984-01-05 | Parke, Davis & Co., 07950 Morris Plains, N.J. | Microtome |
| DE8812708U1 (en) * | 1988-10-10 | 1989-01-05 | Cambridge Instruments GmbH, 6907 Nußloch | Microtome device |
| US4918941A (en) * | 1989-05-16 | 1990-04-24 | Board Of Regents, The University Of Texas System | Cryogenic ultramicrotome seal |
| DE4012600C2 (en) * | 1989-05-26 | 1998-05-14 | Leica Ag | Microtome |
| US5533342A (en) * | 1995-02-08 | 1996-07-09 | Gordon; Abe | Semi-automated cryostat |
| DE10244055B8 (en) * | 2002-09-21 | 2005-10-20 | Microm Int Gmbh | Cryostat microtome with a tempering device |
| JP4840763B2 (en) * | 2006-01-18 | 2011-12-21 | セイコーインスツル株式会社 | Automatic thin section preparation apparatus and automatic thin section preparation apparatus |
| GB0707594D0 (en) * | 2007-04-19 | 2007-05-30 | Ionoptika Ltd | Freeze-fracture sample holder |
| DE102008047415B4 (en) * | 2008-09-16 | 2010-12-02 | Leica Biosystems Nussloch Gmbh | Microtome for making cuts of an object |
| DE102009017848B4 (en) * | 2009-04-17 | 2011-03-17 | Leica Biosystems Nussloch Gmbh | Frozen microtome and method of making microscopic thin sections |
| US10222312B2 (en) * | 2016-06-28 | 2019-03-05 | Anton Paar Quantatec, Inc. | Cryogenic temperature controller for volumetric sorption analyzers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2292973A (en) * | 1941-02-06 | 1942-08-11 | Spencer Lens Co | Microtome |
| US2379932A (en) * | 1944-02-18 | 1945-07-10 | Niagara Blower Co | Heat exchange device |
| US2507632A (en) * | 1944-11-30 | 1950-05-16 | Eastman Kodak Co | Process for dehydrating materials under low-pressure conditions |
| US2670657A (en) * | 1949-06-24 | 1954-03-02 | Rca Corp | High speed microtomy |
| DE1032572B (en) * | 1954-06-01 | 1958-06-19 | Hellmuth Sitte | Microtome, especially ultramicrotome |
| US2961908A (en) * | 1954-09-04 | 1960-11-29 | Villalobos Hum Fernandez-Moran | Microtome |
| US2859946A (en) * | 1955-01-31 | 1958-11-11 | John R Boyle | Heat exchange device |
| US3027734A (en) * | 1960-03-18 | 1962-04-03 | Reflectotherm Inc | Chilling and freezing systems |
-
1963
- 1963-05-06 US US27801463 patent/US3236133A/en not_active Expired - Lifetime
-
1964
- 1964-04-29 GB GB1784364A patent/GB1059772A/en not_active Expired
- 1964-05-05 NL NL6404958A patent/NL6404958A/xx unknown
- 1964-05-05 ES ES0299521A patent/ES299521A1/en not_active Expired
- 1964-05-05 CH CH586764A patent/CH417142A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3236133A (en) | 1966-02-22 |
| GB1059772A (en) | 1967-02-22 |
| NL6404958A (en) | 1964-11-09 |
| CH417142A (en) | 1966-07-15 |
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