ES302128A1 - Procedure for the preparation of new N-substituted N-arilesulfonilureas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new N-substituted N-arilesulfonilureas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES302128A1 ES302128A1 ES0302128A ES302128A ES302128A1 ES 302128 A1 ES302128 A1 ES 302128A1 ES 0302128 A ES0302128 A ES 0302128A ES 302128 A ES302128 A ES 302128A ES 302128 A1 ES302128 A1 ES 302128A1
- Authority
- ES
- Spain
- Prior art keywords
- arylsulfonyl
- group
- translation
- general formula
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 alkoxycarbonylamino radical Chemical class 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Process for the preparation of new N'-substituted N-arylsulfonyl-ureas of the general formula I ** (See formula) ** in which R1 means an alkanoylamino or lower alkoxycarbonylamino radical, the nitro group or the amino group and R2 means hydrogen, halogen, the trifluoromethyl radical or an alkyl or lower alkoxy radical, characterized in that it is reacted, optionally in the presence of a condensing agent, 1-amino-adamantane with an arylsulfonyl isocyanate corresponding to the general formula II, ** (See formula) ** in which R1 'means the nitro group and R2 has the above-indicated significance, or with a functional derivative capable of reacting a N-aryl-sulfonylcarbamyl acid corresponding to general formula III, ** (See formula) ** in which R1 and R2 have the above-indicated significance, if desired a reaction product obtained first of partially hydrolyzes with an alkanoylamino or lower alkoxycarbonylamino group R1 to reach the corresponding compound with an amino group R1 or, if desired, a reaction product is reduced with a nitro group such as R'1 or R1 to reach the corresponding compound with the amino group R1 and/or, if necessary, a partially hydrolyzed N-arylsulfonyl-N '- (1-adamantyl) -guanidine obtained in the first place, for get to the corresponding urea. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH886163A CH421088A (en) | 1963-07-16 | 1963-07-16 | Process for the preparation of new N'-substituted N-arylsulfonylureas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES302128A1 true ES302128A1 (en) | 1965-01-16 |
Family
ID=4345580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0302128A Expired ES302128A1 (en) | 1963-07-16 | 1964-07-15 | Procedure for the preparation of new N-substituted N-arilesulfonilureas. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT246741B (en) |
| BE (1) | BE650563A (en) |
| BR (1) | BR6460887D0 (en) |
| CH (1) | CH421088A (en) |
| DE (1) | DE1203764B (en) |
| DK (1) | DK111522B (en) |
| ES (1) | ES302128A1 (en) |
| FI (1) | FI40898B (en) |
| FR (2) | FR1415578A (en) |
| GB (1) | GB1024495A (en) |
| NL (2) | NL6408093A (en) |
| SE (2) | SE301144B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4288454A (en) * | 1978-07-24 | 1981-09-08 | Hoffman-La Roche Inc. | Antiviral 1-adamantyl-3-(phenylsulfonyl)thioureas |
| HRP20090186A2 (en) | 2009-03-31 | 2010-10-31 | Institut Ruđer Bošković | Adamantane bisurea derivates, method of their preparation and application in anion sensing |
-
0
- NL NL125670D patent/NL125670C/xx active
-
1963
- 1963-07-16 CH CH886163A patent/CH421088A/en unknown
-
1964
- 1964-07-03 FI FI1432/64A patent/FI40898B/fi active
- 1964-07-15 BE BE650563D patent/BE650563A/xx unknown
- 1964-07-15 FR FR981686A patent/FR1415578A/en not_active Expired
- 1964-07-15 DK DK352564AA patent/DK111522B/en unknown
- 1964-07-15 SE SE8672/64A patent/SE301144B/xx unknown
- 1964-07-15 AT AT608864A patent/AT246741B/en active
- 1964-07-15 DE DEG41096A patent/DE1203764B/en active Pending
- 1964-07-15 BR BR160887/64A patent/BR6460887D0/en unknown
- 1964-07-15 GB GB29179/64A patent/GB1024495A/en not_active Expired
- 1964-07-15 ES ES0302128A patent/ES302128A1/en not_active Expired
- 1964-07-16 NL NL6408093A patent/NL6408093A/xx unknown
- 1964-10-14 FR FR991325A patent/FR4001M/fr not_active Expired
-
1968
- 1968-01-11 SE SE35368A patent/SE317371B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE301144B (en) | 1968-05-27 |
| CH421088A (en) | 1966-09-30 |
| FR4001M (en) | 1966-03-14 |
| NL6408093A (en) | 1965-01-18 |
| BE650563A (en) | 1965-01-15 |
| SE317371B (en) | 1969-11-17 |
| DK111522B (en) | 1968-09-09 |
| FR1415578A (en) | 1965-10-29 |
| AT246741B (en) | 1966-05-10 |
| GB1024495A (en) | 1966-03-30 |
| NL125670C (en) | |
| FI40898B (en) | 1969-03-31 |
| DE1203764B (en) | 1965-10-28 |
| BR6460887D0 (en) | 1973-08-02 |
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