ES3057783T3 - Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases - Google Patents

Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases

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Publication number
ES3057783T3
ES3057783T3 ES17710261T ES17710261T ES3057783T3 ES 3057783 T3 ES3057783 T3 ES 3057783T3 ES 17710261 T ES17710261 T ES 17710261T ES 17710261 T ES17710261 T ES 17710261T ES 3057783 T3 ES3057783 T3 ES 3057783T3
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ES
Spain
Prior art keywords
combinations
treatment
neoplastic diseases
lsd1 inhibitors
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
ES17710261T
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English (en)
Inventor
Mark Demario
William Pierceall
Fiona Mack
Tamara Maes
Serena Lunardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oryzon Genomics SA
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Oryzon Genomics SA
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Publication of ES3057783T3 publication Critical patent/ES3057783T3/es
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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Abstract

La presente invención se refiere a combinaciones terapéuticas de inhibidores de LSD1 y uno o más principios activos farmacéuticos adicionales o sales farmacéuticamente aceptables de los mismos. Estas combinaciones son particularmente útiles para el tratamiento de enfermedades neoplásicas, como el cáncer, en particular el cáncer de pulmón de células pequeñas (CPCP). (Traducción automática con Google Translate, sin valor legal)
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