ES3064237T3 - Aqueous retinol formulations - Google Patents

Aqueous retinol formulations

Info

Publication number
ES3064237T3
ES3064237T3 ES24195362T ES24195362T ES3064237T3 ES 3064237 T3 ES3064237 T3 ES 3064237T3 ES 24195362 T ES24195362 T ES 24195362T ES 24195362 T ES24195362 T ES 24195362T ES 3064237 T3 ES3064237 T3 ES 3064237T3
Authority
ES
Spain
Prior art keywords
aqueous
retinol formulations
formulations
aqueous retinol
retinol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES24195362T
Other languages
English (en)
Inventor
Philipp Novak
Christian Seliger
Jochen Bauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orphanix GmbH
Original Assignee
Orphanix GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orphanix GmbH filed Critical Orphanix GmbH
Application granted granted Critical
Publication of ES3064237T3 publication Critical patent/ES3064237T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07Retinol compounds, e.g. vitamin A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES24195362T 2018-11-26 2019-11-26 Aqueous retinol formulations Active ES3064237T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18208340 2018-11-26

Publications (1)

Publication Number Publication Date
ES3064237T3 true ES3064237T3 (en) 2026-04-23

Family

ID=64477035

Family Applications (2)

Application Number Title Priority Date Filing Date
ES19808595T Active ES2988763T3 (es) 2018-11-26 2019-11-26 Formulaciones pediátricas acuosas de retinol
ES24195362T Active ES3064237T3 (en) 2018-11-26 2019-11-26 Aqueous retinol formulations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES19808595T Active ES2988763T3 (es) 2018-11-26 2019-11-26 Formulaciones pediátricas acuosas de retinol

Country Status (18)

Country Link
US (1) US12576046B2 (es)
EP (2) EP4483870B1 (es)
JP (1) JP7774292B2 (es)
KR (1) KR102887267B1 (es)
CN (1) CN113056260A (es)
AU (1) AU2019386241B2 (es)
BR (1) BR112021009781A2 (es)
CA (1) CA3117767A1 (es)
DK (1) DK3880168T3 (es)
ES (2) ES2988763T3 (es)
FI (1) FI3880168T3 (es)
IL (1) IL282833A (es)
MX (1) MX2021005950A (es)
PL (1) PL3880168T3 (es)
PT (1) PT3880168T (es)
SG (1) SG11202104149VA (es)
WO (1) WO2020109272A1 (es)
ZA (1) ZA202104321B (es)

Family Cites Families (43)

* Cited by examiner, † Cited by third party
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US3708583A (en) 1970-04-03 1973-01-02 Vitamin Premixers Of Omaha Inc Stabilized vitamin a additive
GB1464797A (en) 1973-08-02 1977-02-16 American Cyanamid Co Injectable liquid vitamin preparation
US4022913A (en) 1973-09-13 1977-05-10 Hoffmann-La Roche Inc. High potency vitamin A compositions
DE2526938C2 (de) 1975-02-14 1982-04-22 F. Hoffmann-La Roche & Co. AG, 4002 Basel Vitaminpräparate
JPS6025918A (ja) 1983-07-25 1985-02-08 Ajinomoto Co Inc 脂溶性薬物含有水性液
JPS61189216A (ja) 1985-02-18 1986-08-22 Hisamitsu Pharmaceut Co Inc 水溶性ビタミン製剤
JP3256997B2 (ja) 1990-08-30 2002-02-18 千寿製薬株式会社 安定な水性製剤
JP3376597B2 (ja) 1992-01-06 2003-02-10 ライオン株式会社 ビタミンa類及びトコフェロール類含有点眼剤用液剤
JP3199475B2 (ja) 1992-07-21 2001-08-20 ライオン株式会社 ビタミンa類可溶化水溶液の安定化法
AU5861396A (en) 1995-05-19 1996-11-29 Abbott Laboratories Stable aqueous formulations of 1alpha,25-dihydroxycholecalci ferol for parenteral administration
DE19609477A1 (de) 1996-03-11 1997-09-18 Basf Ag Stabile wäßrige Solubilisate von Carotinoiden und Vitamine
DE19609476A1 (de) 1996-03-11 1997-09-18 Basf Ag Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US5935556A (en) 1998-07-30 1999-08-10 The Procter & Gamble Company Sunscreen compositions
PL356968A1 (en) * 1999-04-13 2004-07-12 Leo Pharmaceutical Products Ltd.A/S Solubilized pharmaceutical composition for parenteral administration
KR20010055736A (ko) 1999-12-13 2001-07-04 이규현 프로포폴의 마이크로에멀젼 주사제 조성물
JP3903061B2 (ja) 2003-12-24 2007-04-11 株式会社Lttバイオファーマ 薬物を含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる非経口投与用製剤
RU2294651C1 (ru) 2005-05-31 2007-03-10 Виктор Александрович Быков Способ получения водорастворимого препарата, обогащенного витаминизирующими составляющими, препарат (варианты)
WO2008101344A1 (en) * 2007-02-22 2008-08-28 Peter Tomlinson Soluble bioactive lipophilic compounds compositions
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KR100993291B1 (ko) * 2009-07-16 2010-11-09 대원제약주식회사 프로포폴을 포함하는 주사제용 조성물 및 이의 제조 방법
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Also Published As

Publication number Publication date
EP4483870A3 (en) 2025-04-02
SG11202104149VA (en) 2021-05-28
CA3117767A1 (en) 2020-06-04
NZ775488A (en) 2025-05-02
DK3880168T3 (da) 2024-10-28
EP4483870C0 (en) 2026-02-18
ES2988763T3 (es) 2024-11-21
KR20210096093A (ko) 2021-08-04
FI3880168T3 (fi) 2024-10-31
AU2019386241A1 (en) 2021-05-27
EP3880168B1 (en) 2024-08-21
CN113056260A (zh) 2021-06-29
WO2020109272A1 (en) 2020-06-04
JP7774292B2 (ja) 2025-11-21
EP4483870B1 (en) 2026-02-18
AU2019386241B2 (en) 2024-10-17
JP2022509196A (ja) 2022-01-20
EP4483870A2 (en) 2025-01-01
PL3880168T3 (pl) 2024-12-16
MX2021005950A (es) 2021-07-06
KR102887267B1 (ko) 2025-11-17
ZA202104321B (en) 2023-10-25
IL282833A (en) 2021-06-30
EP3880168A1 (en) 2021-09-22
US12576046B2 (en) 2026-03-17
US20220000802A1 (en) 2022-01-06
BR112021009781A2 (pt) 2021-08-17
PT3880168T (pt) 2024-10-07

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