ES308539A1 - Method for the preparation of derivatives of the tetrahidronaftalina. (Machine-translation by Google Translate, not legally binding) - Google Patents
Method for the preparation of derivatives of the tetrahidronaftalina. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES308539A1 ES308539A1 ES0308539A ES308539A ES308539A1 ES 308539 A1 ES308539 A1 ES 308539A1 ES 0308539 A ES0308539 A ES 0308539A ES 308539 A ES308539 A ES 308539A ES 308539 A1 ES308539 A1 ES 308539A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- preparation
- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- WPWHSFAFEBZWBB-UHFFFAOYSA-N 1-butyl radical Chemical group [CH2]CCC WPWHSFAFEBZWBB-UHFFFAOYSA-N 0.000 abstract 1
- YUDRVAHLXDBKSR-UHFFFAOYSA-N [CH]1CCCCC1 Chemical group [CH]1CCCCC1 YUDRVAHLXDBKSR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical class C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Method for the preparation of tetrahydronaphthalene derivatives, of the general formula ** (See formula) ** where R represents a secondary butyl radical or a cyclohexyl radical, and for obtaining the four theoretically possible stereoisomers corresponding to formula (I) in which R is equal to secondary butyl, which method is characterized by condensing alpha-bromo-5,6,7,8-tetrahydro-2-acetonaphthone with racemic secubutylamine and with one or other of its optical antipodes or with cyclohexylamine; the substituted alpha-amino-5,6,7,8-tetrahiaro-2-acetonaphthone thus obtained and, optionally, separated from the salts, by fractional crystallization, the optical antipodes of 2-secubutylamino-1- (5,6, 7,8-tetrahydro-2-naphthyl) -ethanol. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH49265A CH498082A (en) | 1965-01-14 | 1965-01-14 | Procedure for the preparation of the four theoretically possible stereoisomers of the 2-sec. butylamino-1- (5,6,7,8-tetrahydro-2-naphthyl) -ethanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES308539A1 true ES308539A1 (en) | 1965-12-16 |
Family
ID=4188239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0308539A Expired ES308539A1 (en) | 1965-01-14 | 1965-01-15 | Method for the preparation of derivatives of the tetrahidronaftalina. (Machine-translation by Google Translate, not legally binding) |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH498082A (en) |
| DE (1) | DE1543647B1 (en) |
| ES (1) | ES308539A1 (en) |
| FR (2) | FR1552782A (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1182245B (en) * | 1961-01-23 | 1964-11-26 | Philips Nv | Process for the preparation of a levorotatory 1- (4'-hydroxyphenyl) -2- (1 "-methyl-3" phenylpropylamino) propanol with uterospasmolytic activity |
| BE630210A (en) * | 1962-03-28 | 1963-10-21 | Ici Ltd | Homocyclic compounds. |
-
1965
- 1965-01-14 CH CH49265A patent/CH498082A/en not_active IP Right Cessation
- 1965-01-15 ES ES0308539A patent/ES308539A1/en not_active Expired
-
1966
- 1966-01-14 FR FR1552782D patent/FR1552782A/fr not_active Expired
- 1966-01-14 DE DE19661543647 patent/DE1543647B1/en not_active Withdrawn
- 1966-04-01 FR FR56048A patent/FR5834M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR5834M (en) | 1968-02-26 |
| CH498082A (en) | 1970-10-31 |
| FR1552782A (en) | 1969-01-10 |
| DE1543647B1 (en) | 1971-06-24 |
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