ES310560A1 - Procedure for the preparation of new azepinic derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of new azepine derivatives of the general formula I, ** (See formula) ** in which X means an ethylene or vinyl group, which may be substituted by a methyl group, in the case where Y has the significance of hydrogen, Y means hydrogen, chlorine, a lower alkoxy group, a lower alkylthio group or a lower N, N-dialkylsulphamoyl group, A means a straight or branched chain alkylene radical having 2 to 4 carbon atoms and at least 2 carbon atoms between the 2 nitrogen atoms, R1b means the methyl group or (See formula) a C-pyrrolidinylalkyl radical, C-piperidinylalkyl or C-hexahydroazepinylalkyl with 1 to 2 carbon atoms in the alkyl radical. R 2 means hydrogen or the acyl radical of a non-condensed aliphatic or aromatic monocarboxylic or dicarboxylic acid with at most 10 carbon atoms in total, characterized by the fact that a secondary amine of formula II, ** (See formula) ** wherein Z, Y, A and R1 have the same meaning indicated in formula I It is reacted in an inert solvent with an acidic peroxide to arrive at an N-acyloxide compound the general formula III ** (See formula) ** wherein X, Y, A and R1 have the significance indicated in formula I, and R2 'has the meaning of R2 with the exception of hydrogen and, if desired, the N-acyloxy compounds are treated by solvolysis, in a manner known per se, and, if desired, the compounds obtained from the general formula I, wherein R 2 signifies hydrogen, are transformed by a chloride or carboxylic acid anhydride in a 0-acyl derivative of the general formula I and, if desired, the compounds of the general formula I, in which R 2 signifies hydrogen, are transformed in their salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)