ES317686A1 - Un metodo de preparar clorhidrato de ester etilico de d, l- treo-beta- (p- (2-metil - 1, 3 - dioxolan - 2 - il) fenil) serina - Google Patents
Un metodo de preparar clorhidrato de ester etilico de d, l- treo-beta- (p- (2-metil - 1, 3 - dioxolan - 2 - il) fenil) serinaInfo
- Publication number
- ES317686A1 ES317686A1 ES0317686A ES317686A ES317686A1 ES 317686 A1 ES317686 A1 ES 317686A1 ES 0317686 A ES0317686 A ES 0317686A ES 317686 A ES317686 A ES 317686A ES 317686 A1 ES317686 A1 ES 317686A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- dioxolan
- ethyl ester
- phenyl
- acetylphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
- -1 ethylenedioxy residue Chemical group 0.000 abstract 3
- QCBSHOMDNLCSSL-UHFFFAOYSA-N 4-(2-methyl-1,3-dioxolan-2-yl)benzaldehyde Chemical compound C=1C=C(C=O)C=CC=1C1(C)OCCO1 QCBSHOMDNLCSSL-UHFFFAOYSA-N 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- NTNZTEQNFHNYBC-UHFFFAOYSA-N ethyl 2-aminoacetate Chemical compound CCOC(=O)CN NTNZTEQNFHNYBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 2
- WCGXZTVVXFSESV-NSHDSACASA-N (2S)-3-hydroxy-2-[4-(2-methyl-1,3-dioxolan-2-yl)anilino]propanoic acid Chemical compound CC1(OCCO1)C1=CC=C(C=C1)N[C@@H](CO)C(=O)O WCGXZTVVXFSESV-NSHDSACASA-N 0.000 abstract 1
- JHNJQRIOIMFUBG-UHFFFAOYSA-N 1-[4-(2-amino-1,3-dihydroxypropyl)phenyl]ethanone Chemical compound CC(=O)C1=CC=C(C(O)C(N)CO)C=C1 JHNJQRIOIMFUBG-UHFFFAOYSA-N 0.000 abstract 1
- DHJUYBRZVHFVRO-UHFFFAOYSA-N 2-amino-1-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]propane-1,3-diol Chemical compound CC1(OCCO1)C1=CC=C(C=C1)C(C(CO)N)O DHJUYBRZVHFVRO-UHFFFAOYSA-N 0.000 abstract 1
- VFXLUFBKKPWZEM-UHFFFAOYSA-N 4-(2-methyl-1,3-dioxolan-2-yl)benzonitrile Chemical compound C=1C=C(C#N)C=CC=1C1(C)OCCO1 VFXLUFBKKPWZEM-UHFFFAOYSA-N 0.000 abstract 1
- KTFKRVMXIVSARW-UHFFFAOYSA-N 4-acetylbenzaldehyde Chemical compound CC(=O)C1=CC=C(C=O)C=C1 KTFKRVMXIVSARW-UHFFFAOYSA-N 0.000 abstract 1
- NLPHXWGWBKZSJC-UHFFFAOYSA-N 4-acetylbenzonitrile Chemical compound CC(=O)C1=CC=C(C#N)C=C1 NLPHXWGWBKZSJC-UHFFFAOYSA-N 0.000 abstract 1
- 229910001148 Al-Li alloy Inorganic materials 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910000091 aluminium hydride Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- WOFLMORIDAVSIL-ZOWNYOTGSA-N ethyl (2S)-3-hydroxy-2-[4-(2-methyl-1,3-dioxolan-2-yl)anilino]propanoate hydrochloride Chemical compound Cl.C(C)OC([C@@H](NC1=CC=C(C=C1)C1(OCCO1)C)CO)=O WOFLMORIDAVSIL-ZOWNYOTGSA-N 0.000 abstract 1
- DWWHOKQBZGBBHC-NQCNTLBGSA-N ethyl (2S)-3-hydroxy-3-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-2-[[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]methylideneamino]propanoate Chemical compound C(C)OC([C@@H](N=CC1=CC=C(C=C1)C1(OCCO1)C)C(O)C1=CC=C(C=C1)C1(OCCO1)C)=O DWWHOKQBZGBBHC-NQCNTLBGSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- HKMLRUAPIDAGIE-UHFFFAOYSA-N methyl 2,2-dichloroacetate Chemical compound COC(=O)C(Cl)Cl HKMLRUAPIDAGIE-UHFFFAOYSA-N 0.000 abstract 1
- PKUBDVAOXLEWBF-UHFFFAOYSA-N n-[1-(4-acetylphenyl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide Chemical compound CC(=O)C1=CC=C(C(O)C(CO)NC(=O)C(Cl)Cl)C=C1 PKUBDVAOXLEWBF-UHFFFAOYSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39876564A | 1964-09-23 | 1964-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES317686A1 true ES317686A1 (es) | 1966-07-01 |
Family
ID=23576736
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0317686A Expired ES317686A1 (es) | 1964-09-23 | 1965-09-22 | Un metodo de preparar clorhidrato de ester etilico de d, l- treo-beta- (p- (2-metil - 1, 3 - dioxolan - 2 - il) fenil) serina |
| ES0317685A Expired ES317685A1 (es) | 1964-09-23 | 1965-09-22 | Un procedimiento para preparar 1-(p-acetifenil)-2- (2,2-dicloroacetamido) - 1,3-propanodiol. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0317685A Expired ES317685A1 (es) | 1964-09-23 | 1965-09-22 | Un procedimiento para preparar 1-(p-acetifenil)-2- (2,2-dicloroacetamido) - 1,3-propanodiol. |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE669982A (de) |
| BR (1) | BR6573383D0 (de) |
| CH (2) | CH465638A (de) |
| ES (2) | ES317686A1 (de) |
| GB (2) | GB1117616A (de) |
| SE (1) | SE322207B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005538937A (ja) * | 2002-03-08 | 2005-12-22 | シェーリング−プラウ， リミテッド | 新規なフロルフェニコール型抗生物質 |
| SE0202692D0 (sv) * | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
| US8119667B2 (en) | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
| EP2091909A1 (de) | 2006-12-13 | 2009-08-26 | Schering-Plough Ltd. | Wasserlösliche florfenicol-prodrugs und analoga |
-
1965
- 1965-09-06 GB GB38053/65A patent/GB1117616A/en not_active Expired
- 1965-09-06 GB GB19884/66A patent/GB1117617A/en not_active Expired
- 1965-09-20 CH CH546568A patent/CH465638A/de unknown
- 1965-09-20 CH CH1296365A patent/CH465644A/de unknown
- 1965-09-22 BE BE669982A patent/BE669982A/xx unknown
- 1965-09-22 SE SE12299/65A patent/SE322207B/xx unknown
- 1965-09-22 ES ES0317686A patent/ES317686A1/es not_active Expired
- 1965-09-22 ES ES0317685A patent/ES317685A1/es not_active Expired
- 1965-09-22 BR BR173383/65A patent/BR6573383D0/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR6573383D0 (pt) | 1973-09-11 |
| ES317685A1 (es) | 1966-08-01 |
| GB1117617A (en) | 1968-06-19 |
| GB1117616A (en) | 1968-06-19 |
| CH465638A (de) | 1968-11-30 |
| BE669982A (de) | 1966-03-22 |
| CH465644A (de) | 1968-11-30 |
| SE322207B (de) | 1970-04-06 |
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