ES320436A1 - Un procedimiento para la preparacion de sustancias antibioticas. - Google Patents

Un procedimiento para la preparacion de sustancias antibioticas.

Info

Publication number: ES320436A1
Authority: ES; Spain
Prior art keywords: translation; dissolved material; preparation; legally binding; google translate
Prior art date: 1964-12-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES0320436A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

DANBAL A G

Original Assignee

DANBAL A G

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1964-12-07

Filing date

1965-12-06

Publication date

1966-05-16

1965-12-06 Application filed by DANBAL A G filed Critical DANBAL A G

1966-05-16 Publication of ES320436A1 publication Critical patent/ES320436A1/es

Status Expired legal-status Critical Current

Links

230000003115 biocidal effect Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000000126 substance Substances 0.000 title abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
239000000463 material Substances 0.000 abstract 3
239000002904 solvent Substances 0.000 abstract 3
238000000605 extraction Methods 0.000 abstract 2
238000000855 fermentation Methods 0.000 abstract 2
230000004151 fermentation Effects 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
241001655322 Streptomycetales Species 0.000 abstract 1
238000005273 aeration Methods 0.000 abstract 1
238000009835 boiling Methods 0.000 abstract 1
235000014633 carbohydrates Nutrition 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
235000015097 nutrients Nutrition 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
241000894007 species Species 0.000 abstract 1
238000003756 stirring Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES0320436A 1964-12-07 1965-12-06 Un procedimiento para la preparacion de sustancias antibioticas. Expired ES320436A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US416599A US3361742A (en)	1964-12-07	1964-12-07	5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides

Publications (1)

Publication Number	Publication Date
ES320436A1 true ES320436A1 (es)	1966-05-16

Family

ID=23650586

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES0320436A Expired ES320436A1 (es)	1964-12-07	1965-12-06	Un procedimiento para la preparacion de sustancias antibioticas.

Country Status (11)

Country	Link
US (1)	US3361742A (es)
AT (1)	AT269350B (es)
BE (1)	BE673376A (es)
BR (1)	BR6575537D0 (es)
CH (1)	CH475997A (es)
DE (1)	DE1467872A1 (es)
ES (1)	ES320436A1 (es)
FR (1)	FR1553664A (es)
GB (1)	GB1092888A (es)
NL (1)	NL6515880A (es)
SE (1)	SE316136B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3523941A (en) *	1967-03-06	1970-08-11	Hoffmann La Roche	Benzodiazepine compounds and process for their preparation
US3524849A (en) *	1967-10-27	1970-08-18	Hoffmann La Roche	Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein
FR2027356A1 (en) *	1968-12-30	1970-09-25	Fujisawa Pharmaceutical Co	Benzodiazepinone antibiotics
JPS5279082A (en) *	1975-12-25	1977-07-02	Green Cross Corp:The	Preparation of anti-tumor compound
JPS585916B2 (ja)	1977-12-27	1983-02-02	株式会社ミドリ十字	新規ベンゾジアゼピン系化合物
CA1214774A (en) *	1983-02-10	1986-12-02	Yusei Shiraga	Benzodiazepine derivative
AUPO470197A0 (en) *	1997-01-21	1997-02-13	Attfield, Paul Victor	Fluorescent dyes from microorganisms
JP5870400B2 (ja)	2010-04-15	2016-03-01	シアトルジェネティクス，インコーポレーテッド	標的化ピロロベンゾジアゼピンコンジュゲート
ES2623057T3 (es)	2010-04-15	2017-07-10	Medimmune Limited	Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
SG11201400770SA (en)	2011-09-20	2014-04-28	Spirogen Sarl	Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
US9526798B2 (en)	2011-10-14	2016-12-27	Seattle Genetics, Inc.	Pyrrolobenzodiazepines and targeted conjugates
SG11201401021TA (en)	2011-10-14	2014-08-28	Spirogen Sarl	Pyrrolobenzodiazepines
CN103998449A (zh)	2011-10-14	2014-08-20	斯皮罗根有限公司	吡咯并苯并二氮杂卓
MX358757B (es)	2011-10-14	2018-09-03	Seattle Genetics Inc	Pirrolobenzodiazepinas y conjugados dirigidos.
WO2014057120A1 (en)	2012-10-12	2014-04-17	Adc Therapeutics Sàrl	Pyrrolobenzodiazepine-antibody conjugates
ES2649990T3 (es)	2012-10-12	2018-01-16	Medimmune Limited	Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas
US9745303B2 (en)	2012-10-12	2017-08-29	Medimmune Limited	Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
EP2906296B1 (en)	2012-10-12	2018-03-21	ADC Therapeutics SA	Pyrrolobenzodiazepine-antibody conjugates
WO2014057114A1 (en)	2012-10-12	2014-04-17	Adc Therapeutics Sàrl	Pyrrolobenzodiazepine-anti-psma antibody conjugates
BR112015008251B1 (pt)	2012-10-12	2023-09-26	Medimmune Limited	Pirrolobenzodiazepinas, conjugados destas, composição e composição farmacêutica compreendendo os conjugados, uso dos conjugados para o tratamento de uma doença proliferativa e método para preparar os conjugados
NZ707486A (en)	2012-10-12	2018-09-28	Adc Therapeutics Sa	Pyrrolobenzodiazepine - anti-psma antibody conjugates
US9931414B2 (en)	2012-10-12	2018-04-03	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
ES2738310T3 (es)	2012-10-12	2020-01-21	Medimmune Ltd	Pirrolobenzodiazepinas y conjugados de las mismas
GB201317982D0 (en)	2013-10-11	2013-11-27	Spirogen Sarl	Pyrrolobenzodiazepines and conjugates thereof
EP3054985B1 (en)	2013-10-11	2018-12-26	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
EP3054986B1 (en)	2013-10-11	2019-03-20	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
EP3054983B1 (en)	2013-10-11	2019-03-20	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en)	2013-10-11	2013-11-27	Spirogen Sarl	Pyrrolobenzodiazepines and conjugates thereof
GB201416112D0 (en)	2014-09-12	2014-10-29	Medimmune Ltd	Pyrrolobenzodiazepines and conjugates thereof
EP3223854A1 (en)	2014-11-25	2017-10-04	ADC Therapeutics SA	Pyrrolobenzodiazepine-antibody conjugates
GB201506411D0 (en)	2015-04-15	2015-05-27	Bergenbio As	Humanized anti-axl antibodies
GB201506402D0 (en)	2015-04-15	2015-05-27	Berkel Patricius H C Van And Howard Philip W	Site-specific antibody-drug conjugates
GB201601431D0 (en)	2016-01-26	2016-03-09	Medimmune Ltd	Pyrrolobenzodiazepines
GB201602359D0 (en)	2016-02-10	2016-03-23	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en)	2016-02-10	2016-03-23	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en)	2016-04-29	2016-06-15	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en)	2016-10-14	2016-11-30	Medimmune Ltd	Pyrrolobenzodiazepine conjugates
GB201702031D0 (en)	2017-02-08	2017-03-22	Medlmmune Ltd	Pyrrolobenzodiazepine-antibody conjugates
US11160872B2 (en)	2017-02-08	2021-11-02	Adc Therapeutics Sa	Pyrrolobenzodiazepine-antibody conjugates
EP3612537B1 (en)	2017-04-18	2022-07-13	Medimmune Limited	Pyrrolobenzodiazepine conjugates
CN110536703B (zh)	2017-04-20	2024-07-12	Adc治疗有限公司	使用抗axl抗体-药物缀合物的组合疗法
UA127900C2 (uk)	2017-06-14	2024-02-07	Ейдісі Терапьютікс Са	Схема дозування для введення adc до cd19
RS62928B1 (sr)	2017-08-18	2022-03-31	Medimmune Ltd	Konjugati pirolobenzodiazepina
GB201803342D0 (en)	2018-03-01	2018-04-18	Medimmune Ltd	Methods
GB201806022D0 (en)	2018-04-12	2018-05-30	Medimmune Ltd	Pyrrolobenzodiazepines and conjugates thereof
ES2967878T3 (es)	2019-03-15	2024-05-06	Medimmune Ltd	Dímeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento del cáncer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3247187A (en) *	1963-07-10	1966-04-19	Hoffmann La Roche	Oxidation of 1, 4-benzodiazepines to 1, 4-benzodiazepin-2-ones

1964
- 1964-12-07 US US416599A patent/US3361742A/en not_active Expired - Lifetime
1965
- 1965-12-03 FR FR1553664D patent/FR1553664A/fr not_active Expired
- 1965-12-04 DE DE19651467872 patent/DE1467872A1/de active Pending
- 1965-12-06 ES ES0320436A patent/ES320436A1/es not_active Expired
- 1965-12-06 GB GB51119/65A patent/GB1092888A/en not_active Expired
- 1965-12-06 AT AT1097465A patent/AT269350B/de active
- 1965-12-07 BR BR175537/65A patent/BR6575537D0/pt unknown
- 1965-12-07 BE BE673376D patent/BE673376A/xx unknown
- 1965-12-07 SE SE15830/65A patent/SE316136B/xx unknown
- 1965-12-07 CH CH1683365A patent/CH475997A/de not_active IP Right Cessation
- 1965-12-07 NL NL6515880A patent/NL6515880A/xx unknown

Also Published As

Publication number	Publication date
FR1553664A (es)	1969-01-17
CH475997A (de)	1969-07-31
NL6515880A (es)	1966-06-08
BE673376A (es)	1966-04-01
US3361742A (en)	1968-01-02
GB1092888A (en)	1967-11-29
BR6575537D0 (pt)	1973-09-06
AT269350B (de)	1969-03-10
SE316136B (es)	1969-10-20
DE1467872A1 (de)	1969-05-14

Publication	Publication Date	Title
ES377347A1 (es)	1973-04-16	Metodo de preparacion de una composicion controladora de bacterias.
GB1083662A (en)	1967-09-20	A novel antibiotic, methods for its production and therapeutic compositions containing it
Farkas-Himsley et al.	1962	Lethal biosynthesis of a new antibacterial principle: vibriocin
GB1357538A (en)	1974-06-26	New antibiotic
JPS5299289A (en)	1977-08-19	Preparation of l-arginine by fermentation
GB1158387A (en)	1969-07-16	Procedure for Isolation of Mycophenolic Acid
GB1511868A (en)	1978-05-24	Process for conditioning bacterial cells containing glucose isomerase activity
GB1417194A (en)	1975-12-10	Method and apparatus for anaerobic fermentation
ES386128A1 (es)	1973-12-16	Un procedimiento de fermentacion perfeccionado para la pro-duccion de proteina de alta calidad.
SE332263B (es)	1971-02-01
ES394210A1 (es)	1974-11-01	Un procedimiento para la preparacion de una nueva sustanciaantibiotica de amplio espectro antimicrobiano.
ES313427A1 (es)	1966-02-01	Un metodo para la preparacion de una vacuna de brucella abortus viviente.
ES323766A1 (es)	1967-01-16	Un procedimiento para la preparacion de amilasa estable y activa en medio acido.
GB967596A (en)	1964-08-26	Gibberellic acid intermediates
ES262125A3 (es)	1961-05-16	Procedimiento para preparar un nuevo antibiëtico
ES422625A1 (es)	1976-09-01	Un procedimiento para la produccion de bicilomicina.
ES387479A1 (es)	1974-09-01	Un procedimiento para producir una sustancia antibiotica- mente activa.
ES408050A3 (es)	1975-11-16	Procedimiento de obtencion de salinomicina.
Hwang et al.	1987	Seasonal changes of paralytic toxicity in purple clam, Soletellina diphos, and identification of the responsible toxin. In: P. Gopalakrishnakone and CK Tan (eds.)
ES353289A1 (es)	1969-08-16	Un procedimiento microbiologico para preparar la sustancia antibiotica libanomicina.
ES242240A1 (es)	1958-12-01	UN PROCEDIMIENTO PARA LA PRODUCCIoN DE COBALAMINAS.
JPS5462392A (en)	1979-05-19	Preparation of antibiotic substance, sisomicin
ES269580A1 (es)	1961-12-16	Un procedimiento para preparar el antibiëtico capromicina
ES325719A1 (es)	1966-10-01	Procedimiento para la preparaciën de materias negras humicas por degradaciën estrictamente anaerëbia de materias organicas
ES416742A1 (es)	1976-06-01	Procedimiento para preparar por fermentacion un producto antibioticamente activo que contiene antibiotico g-52 y si- somicina.