ES320749A1 - Procedure for the obtaining of 1-isopropilamino - 2-hidroxi-3- (o-propargiloxi-fenoxi) - propane. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of 1-isopropilamino - 2-hidroxi-3- (o-propargiloxi-fenoxi) - propane. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES320749A1
ES320749A1 ES0320749A ES320749A ES320749A1 ES 320749 A1 ES320749 A1 ES 320749A1 ES 0320749 A ES0320749 A ES 0320749A ES 320749 A ES320749 A ES 320749A ES 320749 A1 ES320749 A1 ES 320749A1
Authority
ES
Spain
Prior art keywords
propane
propargyloxy
phenoxy
isopropylamino
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0320749A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
BASF Schweiz AG
Original Assignee
Ciba Geigy AG
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1631364A external-priority patent/CH448994A/en
Priority claimed from CH1257365A external-priority patent/CH481875A/en
Application filed by Ciba Geigy AG, Ciba AG filed Critical Ciba Geigy AG
Publication of ES320749A1 publication Critical patent/ES320749A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)

Abstract

"Process for the preparation of 1-isopropylamino-2-hydroxy-3- (o-propargyloxy-phenoxy) -propane" of formula I ** (See formula) ** characterized, because a 3- (o-propargyloxy-phenoxy) -1,2-dihydroxy-propane or 3- (o-propargyloxy-phenoxy) -1,2-epoxy-propane esterified in a form capable of reaction at the hydroxyl radical in position 1, is reacted with isopropylamine or at the amino radical of 1-amino-2-hydroxy-3- (o-propargyloxy-phenoxy) -propane the isopropyl moiety is introduced or the o-propargyloxy-phenol is reacted with an esterified 3-isopropylamino-1,2-dihydroxypropane capable of reaction at the hydroxyl radical in the 1-position or with 3-isopropylamino-1,2-epoxy-propane, or in a 1-isopropylamino-2-hydroxy-3 - (o-propargiloxi-phenoxy) -propane, which at the nitrogen atom and/or at the 2-hydroxyl radical shows a dissociable moiety by hydrolysis, this is dissociated, or in a compound of formula II ** (See formula) ** where Y means a reachable transformable by reduction of a double bond C-N in the radical of formula ** (See formula) ** a 1-isopropylamino-2-oxo-3- (o-propargyloxy-phenoxy) -propane reduces carbinol. (Machine-translation by Google Translate, not legally binding)
ES0320749A 1964-12-17 1965-12-15 Procedure for the obtaining of 1-isopropilamino - 2-hidroxi-3- (o-propargiloxi-fenoxi) - propane. (Machine-translation by Google Translate, not legally binding) Expired ES320749A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1631364A CH448994A (en) 1964-12-17 1964-12-17 Process for the preparation of a new amine
CH1257365A CH481875A (en) 1965-09-09 1965-09-09 Process for the preparation of a new amine

Publications (1)

Publication Number Publication Date
ES320749A1 true ES320749A1 (en) 1966-11-16

Family

ID=25710554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0320749A Expired ES320749A1 (en) 1964-12-17 1965-12-15 Procedure for the obtaining of 1-isopropilamino - 2-hidroxi-3- (o-propargiloxi-fenoxi) - propane. (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
DK (1) DK117065B (en)
ES (1) ES320749A1 (en)
NL (1) NL6516433A (en)
SE (1) SE338771B (en)

Also Published As

Publication number Publication date
NL6516433A (en) 1966-06-20
SE338771B (en) 1971-09-20
DK117065B (en) 1970-03-16

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