ES321632A1 - Procedure for the preparation of 5,6-dihydro-6-oxomorphantridines 5-basically substituted. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 5,6-dihydro-6-oxomorphantridines 5-basically substituted. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES321632A1
ES321632A1 ES0321632A ES321632A ES321632A1 ES 321632 A1 ES321632 A1 ES 321632A1 ES 0321632 A ES0321632 A ES 0321632A ES 321632 A ES321632 A ES 321632A ES 321632 A1 ES321632 A1 ES 321632A1
Authority
ES
Spain
Prior art keywords
formula
dihydro
preparation
translation
meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0321632A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wander AG
Original Assignee
Wander AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wander AG filed Critical Wander AG
Publication of ES321632A1 publication Critical patent/ES321632A1/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Process for the preparation of 5-basicly substituted 5,6-dihydro-6-oxomorfantridines of the formula: ** (See formula) ** wherein R means a straight or branched alkyl group with 2 to 4 C atoms, R1 and R2 are the same or different and mean hydrogen or alkyl with a maximum of 3 C atoms, and one of both R3 represents hydrogen, the other halogen, as well as acid addition salts thereof, characterized in that either a) Amines of the formula XH are reacted, optionally after preceding or simultaneous action of a condensation medium, with reactable esters of alcohols of the formula YR-OH, X and Y being interchangeable with each other, and, on the one hand, a halogenated 5,6-dihydro-6-oxo-5-morfantridinyl residue in one of both bezo nuclei, on the other hand, represent the basic remainder (see formula) while R, R1 and R2 have the meaning mentioned above, or because b) They are cyclized, with the evolution of water, respectively of an alcohol, an acid or an ester, o-amino-o'-carboxy, (respectively carbalkoxy) -1,1-diphenylmethanes n-aminoalkylates of the formula: ** (See formula) ** in which R, R1, R2 and R3 have the meaning indicated above meaning R4, hydrogen or a lower alkyl group, or because c) For the preparation of compounds according to formula I, in which R1 and/or R2 means alkyl, they are lower alkylated, primary or secondary amines of the formula: ** (See formula) ** wherein R, R1 and R3 have the meaning indicated above after which the reaction product is isolated in the form of the free base or of an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0321632A 1965-01-11 1966-01-11 Procedure for the preparation of 5,6-dihydro-6-oxomorphantridines 5-basically substituted. (Machine-translation by Google Translate, not legally binding) Expired ES321632A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH32865 1965-01-11

Publications (1)

Publication Number Publication Date
ES321632A1 true ES321632A1 (en) 1966-09-01

Family

ID=4184509

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0321632A Expired ES321632A1 (en) 1965-01-11 1966-01-11 Procedure for the preparation of 5,6-dihydro-6-oxomorphantridines 5-basically substituted. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
AT (3) AT260273B (en)
DE (1) DE1620723A1 (en)
DK (1) DK119008B (en)
ES (1) ES321632A1 (en)
FR (1) FR5817M (en)
GB (1) GB1085101A (en)
NL (1) NL6600293A (en)

Also Published As

Publication number Publication date
GB1085101A (en) 1967-09-27
FR5817M (en) 1968-02-26
DE1620723A1 (en) 1970-08-27
AT260272B (en) 1968-02-26
AT260273B (en) 1968-02-26
NL6600293A (en) 1966-07-12
DK119008B (en) 1970-11-02
AT260260B (en) 1968-02-26

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