ES328271A1 - Procedure for obtaining oxacepine derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for obtaining oxacepine derivatives (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES328271A1 ES328271A1 ES0328271A ES328271A ES328271A1 ES 328271 A1 ES328271 A1 ES 328271A1 ES 0328271 A ES0328271 A ES 0328271A ES 328271 A ES328271 A ES 328271A ES 328271 A1 ES328271 A1 ES 328271A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- aminoalkyl
- amino
- oxacepin
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 5
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"Procedure for obtaining oxacepin derivatives", which correspond to the general name 10-aminoalkyl-11-X-10,11-dihydro-dibenzo [b, f] [1,4] oxacepin, in which X means 2 hydrogen atoms or an oxo radical and the amino radical is separated from the ring nitrogen atom by at least 2 carbon atoms, and in which at least one of the benzene rings contains a nitro radical, or the salts of the same, characterized in that in the 10-Ro-11-X-10, 11-dihydro-dibenzo [b, f] [1,4] oxacepin, which in at least one of the benzene rings contain a radical nitro and in which Ro means a transformable moiety in an aminoalkyl radical, or salts thereof, the radical Ro is converted to an aminoalkyl residue in which the amino radical is separated from the ring nitrogen atom by at least 2 atoms carbon, or b) in an ether N- (aminoalkyl) -N-Xo-amino-o'-Xoa-diphenyl, in which the two amino radicals are separated at least at 2 carbon atoms and at least one of the phenyl residues contains a nitro radical, and in which Xo means a hydrogen atom or an acyl radical and Xoa a substituent which under the conditions of the ring closure forms the radical of formula -C (= X) -, the ring is closed and, if desired, in an obtained compound an aminoalkyl radical is transformed into another amino alkyl moiety, and/or, if desired, a compound obtained is transformed in a salt or a salt obtained in the free compound or in another salt, and/or, if desired, a mixture of isomers obtained is transformed into the different isomers. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH880565A CH484177A (en) | 1965-06-23 | 1965-06-23 | Process for the preparation of oxazaheterocycles |
| CH609266A CH500220A (en) | 1965-06-23 | 1966-04-27 | 10-Aminoalkyl-10,11-dihydro-dibenzo(b,f)(1,4)oxazepines - antidepressants with acetylcholine, anti-serotonin and antihistamine activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES328271A1 true ES328271A1 (en) | 1967-08-01 |
Family
ID=25698957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0328271A Expired ES328271A1 (en) | 1965-06-23 | 1966-06-22 | Procedure for obtaining oxacepine derivatives (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| AT (1) | AT269142B (en) |
| ES (1) | ES328271A1 (en) |
-
1966
- 1966-06-22 AT AT594366A patent/AT269142B/en active
- 1966-06-22 ES ES0328271A patent/ES328271A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT269142B (en) | 1969-03-10 |
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