ES329085A1 - A PROCEDURE FOR PREPARING NITROIMIDAZOLES. - Google Patents

A PROCEDURE FOR PREPARING NITROIMIDAZOLES.

Info

Publication number
ES329085A1
ES329085A1 ES0329085A ES329085A ES329085A1 ES 329085 A1 ES329085 A1 ES 329085A1 ES 0329085 A ES0329085 A ES 0329085A ES 329085 A ES329085 A ES 329085A ES 329085 A1 ES329085 A1 ES 329085A1
Authority
ES
Spain
Prior art keywords
alkyl
formula
compound
nitro
alkanoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0329085A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES329085A1 publication Critical patent/ES329085A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91Nitro radicals
    • C07D233/92Nitro radicals attached in position 4 or 5
    • C07D233/94Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91Nitro radicals
    • C07D233/92Nitro radicals attached in position 4 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Devices For Checking Fares Or Tickets At Control Points (AREA)

Abstract

A process for preparing nitroimidazoles, and more especially a compound having the formula: ** (See formula) ** where A and M are oxygen and sulfur, and R1 'is R1 or hydroxyalkyl, and R1 is alkyl or substituted alkyl, wherein said substituent is oxo, alkenyl, alkanoyloxy, phenylalkanoyloxy, alkoxy, phenylalkoxy, carboxyl, carboalkoxy, carbophenylalkoxy, carbamoyl, alkylcarbamoyl, phenylalkylcarbaryl, phenylcarbamoyl, cyano, halo, alkylthio, phenylalkylthio, alkyl sulfinyl, phenylalkyl-sulfinyl, phenylsulphinyl, alkylsulfonyl, phenylalkyl-sulphonyl, phenylsulphonyl or dialkylamino, carbamoyloxy; R3 is hydrogen, alkyl, or substituted alkyl, wherein the alkyl substituents are halo, alkoxy, oxo, phenyloxo, carboalkoxy, carbophenylalkoxy, alkanoyloxy, phenylalkanoyloxy, alkylthio, phenylalkylthio, dialkyldithiocarbamoyl, diphenylalkyldithiocarbamoyl, diphenyldithiocarbamoyl, dialkylamino, diphenylalkylamino or heterocycloalkyl; alkylsulfonyl or phenylsulfonyl; phenyl, alkanoyl, phenylalkanoyl, aroyl, cyanoacetyl, alkenoyl, chlorosulfonyl or dichlorophosphoryl; is lower alkylene, lower alkenylene, lower phenylalkylene, or lower alkylidene; W is nitro, cyano, phenyl or hydrogen; and P is hydrogen or nitro, provided that one of the groups W and P is nitro, which comprises reacting a compound having the formula ** (See formula) ** with a compound that has the formula R3-N-C=M III where A, M, P, Q, R1 and R3 are as defined above, and where R1 is alanoyloxyalkyl, if it is desired to hydrolyze with a base to obtain the corresponding compound where R1 'is hydroxyalkyl in which the terms alkyl, alkanoyl, and Alkoxyl mentioned above, denote lower alkyl, lower alkanoyl, and lower alkoxy, each containing 1 to 5 carbon atoms. (Machine-translation by Google Translate, not legally binding)
ES0329085A 1965-07-07 1966-07-05 A PROCEDURE FOR PREPARING NITROIMIDAZOLES. Expired ES329085A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47023965A 1965-07-07 1965-07-07
US55093266A 1966-05-18 1966-05-18

Publications (1)

Publication Number Publication Date
ES329085A1 true ES329085A1 (en) 1967-05-01

Family

ID=27043018

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0329085A Expired ES329085A1 (en) 1965-07-07 1966-07-05 A PROCEDURE FOR PREPARING NITROIMIDAZOLES.

Country Status (18)

Country Link
JP (3) JPS5010865B1 (en)
AT (5) AT291989B (en)
BE (1) BE683796A (en)
BR (1) BR6681050D0 (en)
CH (3) CH522651A (en)
CY (1) CY565A (en)
DE (1) DE1620018B2 (en)
DK (1) DK141287B (en)
ES (1) ES329085A1 (en)
FI (1) FI46961C (en)
FR (2) FR1502699A (en)
GB (5) GB1154290A (en)
IL (2) IL25931A (en)
IT (1) IT1061026B (en)
MY (1) MY7100055A (en)
NL (1) NL149793B (en)
NO (1) NO122186B (en)
SE (1) SE343578B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1280355A (en) * 1969-06-20 1972-07-05 Rech S Et D Applic Scient Et M Substituted 5-nitro-imidazoles and their preparation
BE758145A (en) * 1969-10-29 1971-04-28 Smith Kline French Lab ISO-THIO-UREES AND DERIVATIVES
US3678066A (en) * 1970-03-06 1972-07-18 Squibb & Sons Inc Thiocyanic acid esters
US3968228A (en) * 1973-11-13 1976-07-06 Merck & Co., Inc. 4-Nitro-5-cyanoimidazoles as coccidiostats
JPH02254965A (en) * 1989-03-28 1990-10-15 Chiyoudendou Hatsuden Kanren Kiki Zairyo Gijutsu Kenkyu Kumiai Rotor for superconducting rotary electric machine
CR20170445A (en) 2015-04-02 2018-02-06 Bayer Cropscience Ag NEW DERIVATIVES OF IMIDAZOLILMETILO 5-SUBSTITUTES
WO2018060091A1 (en) 2016-09-29 2018-04-05 Bayer Cropscience Aktiengesellschaft Novel 5-substituted imidazolylmethyl derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5149436B2 (en) * 1971-11-15 1976-12-27

Also Published As

Publication number Publication date
JPS5010865B1 (en) 1975-04-24
BR6681050D0 (en) 1973-05-15
JPS4843909B1 (en) 1973-12-21
MY7100055A (en) 1971-12-31
FI46961B (en) 1973-05-02
NL6609552A (en) 1967-01-09
AT284114B (en) 1970-09-10
DE1620018B2 (en) 1976-04-15
GB1155529A (en) 1969-06-18
AT291990B (en) 1971-08-10
GB1154290A (en) 1969-06-04
FR1502699A (en) 1967-11-24
DK141287C (en) 1980-07-07
CH522651A (en) 1972-05-15
BE683796A (en) 1967-01-09
AT294487B (en) 1971-11-25
CY565A (en) 1970-11-09
FI46961C (en) 1973-08-10
GB1155530A (en) 1969-06-18
IL25931A (en) 1972-01-27
JPS5138718B1 (en) 1976-10-23
FR5890M (en) 1968-03-18
NL149793B (en) 1976-06-15
NO122186B (en) 1971-06-01
GB1155528A (en) 1969-06-18
DK141287B (en) 1980-02-18
AT291988B (en) 1971-08-10
DE1620018A1 (en) 1970-03-05
GB1153347A (en) 1969-05-29
AT291989B (en) 1971-08-10
IT1061026B (en) 1982-10-20
CH562806A5 (en) 1975-06-13
IL35748A0 (en) 1971-01-28
SE343578B (en) 1972-03-13
CH565769A5 (en) 1975-08-29

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