ES334064A1 - A procedure for the preparation of new substitute amines. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of new substitute amines. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES334064A1 ES334064A1 ES0334064A ES334064A ES334064A1 ES 334064 A1 ES334064 A1 ES 334064A1 ES 0334064 A ES0334064 A ES 0334064A ES 334064 A ES334064 A ES 334064A ES 334064 A1 ES334064 A1 ES 334064A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- group
- compound
- hydrogen
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001412 amines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003158 alcohol group Chemical group 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 229960004559 theobromine Drugs 0.000 abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229960000278 theophylline Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for the preparation of new substituted amines of the general formula I, or their salts with pharmaceutically acceptable acids **(See formula)** wherein R1 represents hydrogen or an alcoholic group, R2 hydrogen or a hydroxyl group, R3 and R4 an optionally etherified hydroxyl group, a halogen or an alcoholic group, A represents a radical (see formula) or Th-CH-CH2- in which Th means theobromine or theophylline and R5 means hydrogen or a hydroxyl group, and Z can have the same significance as A or can mean a hydrogen atom or an alcohol group, with the provided that when Z stands for a hydrogen atom or an alcohol group, the substituent A stands for a group (see formula), characterized in that a compound of formula IV is reacted directly **(See formula)** where R1 to R4 have the above meanings and R6 means a hydrogen atom or a group of formula V and a compound of formula V **(See formula)** or with a compound of formula V and a compound of formula VI Th-CH2-CH2 - X (VI) in which Th and R5 have the above significance and X represents halogen, or it is first reacted with epichlorohydrin and the resulting reaction products are then reacted with theobromine or taophylline or optionally both. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1111865A AT269171B (en) | 1965-12-10 | 1965-12-10 | Process for the preparation of new substituted amines and their salts |
| AT272766A AT270673B (en) | 1966-03-22 | 1966-03-22 | Process for the preparation of new substituted amines or their salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES334064A1 true ES334064A1 (en) | 1967-10-16 |
Family
ID=25598985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0334064A Expired ES334064A1 (en) | 1965-12-10 | 1966-12-02 | A procedure for the preparation of new substitute amines. (Machine-translation by Google Translate, not legally binding) |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5113160B1 (en) |
| BE (1) | BE690863A (en) |
| CH (2) | CH496013A (en) |
| DE (1) | DE1695100A1 (en) |
| ES (1) | ES334064A1 (en) |
| FR (2) | FR1504939A (en) |
| GB (1) | GB1156719A (en) |
| SE (1) | SE345669B (en) |
-
1966
- 1966-11-30 DE DE19661695100 patent/DE1695100A1/en active Pending
- 1966-12-02 ES ES0334064A patent/ES334064A1/en not_active Expired
- 1966-12-08 BE BE690863D patent/BE690863A/xx unknown
- 1966-12-08 CH CH1755266A patent/CH496013A/en not_active IP Right Cessation
- 1966-12-08 SE SE16834/66A patent/SE345669B/xx unknown
- 1966-12-08 CH CH991470A patent/CH496014A/en not_active IP Right Cessation
- 1966-12-08 JP JP41080097A patent/JPS5113160B1/ja active Pending
- 1966-12-09 FR FR86792A patent/FR1504939A/en not_active Expired
- 1966-12-09 GB GB55188/66A patent/GB1156719A/en not_active Expired
-
1967
- 1967-03-09 FR FR98053A patent/FR7018M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1504939A (en) | 1967-12-08 |
| JPS5113160B1 (en) | 1976-04-26 |
| GB1156719A (en) | 1969-07-02 |
| DE1695100A1 (en) | 1970-12-10 |
| CH496014A (en) | 1970-09-15 |
| BE690863A (en) | 1967-06-08 |
| SE345669B (en) | 1972-06-05 |
| FR7018M (en) | 1969-06-09 |
| CH496013A (en) | 1970-09-15 |
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