ES334818A1 - PROCEDURE TO PREPARE SUBSTITUTE 1,3-BENZOXACINS. - Google Patents
PROCEDURE TO PREPARE SUBSTITUTE 1,3-BENZOXACINS.Info
- Publication number
- ES334818A1 ES334818A1 ES334818A ES334818A ES334818A1 ES 334818 A1 ES334818 A1 ES 334818A1 ES 334818 A ES334818 A ES 334818A ES 334818 A ES334818 A ES 334818A ES 334818 A1 ES334818 A1 ES 334818A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- procedure
- benzoxacin
- benzoxacins
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure to prepare substituted 1,3-benzoxacines from the structure ** (See formula) ** where R and R1 may be the same or different and mean hydrogen, halogen, a cyano or nitro group or an optionally substituted alkyl or alkoxy radical of 1 to 4 carbon atoms, R 'and R "may be the same or different and mean hydrogen, phenyl or an alkyl radical of 1 to 4 carbon atoms, optionally substituted, while n is 1 or 2, characterized by reacting the hydroxyarylamino-alkylcarboxylic acid ester with phosgene and then reacting 3-carboalkoxy-alkyl-1,3-benzoxacin-2-one with ammonia to obtain 3-carboxanido-alkyl-1,3-benzoxacin-2- ona (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1263865 | 1965-12-23 | ||
| IT2238566 | 1966-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES334818A1 true ES334818A1 (en) | 1968-03-01 |
Family
ID=26326577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES334818A Expired ES334818A1 (en) | 1965-12-23 | 1966-12-22 | PROCEDURE TO PREPARE SUBSTITUTE 1,3-BENZOXACINS. |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT264535B (en) |
| BE (1) | BE691641A (en) |
| ES (1) | ES334818A1 (en) |
| FI (1) | FI46729C (en) |
| IL (1) | IL27092A (en) |
| NO (1) | NO121044B (en) |
| SE (1) | SE316773B (en) |
-
1966
- 1966-12-19 IL IL2709266A patent/IL27092A/en unknown
- 1966-12-20 FI FI338866A patent/FI46729C/en active
- 1966-12-21 AT AT1175266A patent/AT264535B/en active
- 1966-12-22 NO NO16610266A patent/NO121044B/no unknown
- 1966-12-22 ES ES334818A patent/ES334818A1/en not_active Expired
- 1966-12-22 SE SE1755966A patent/SE316773B/xx unknown
- 1966-12-22 BE BE691641D patent/BE691641A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1620436A1 (en) | 1970-05-21 |
| NO121044B (en) | 1971-01-11 |
| AT264535B (en) | 1968-09-10 |
| SE316773B (en) | 1969-11-03 |
| FI46729B (en) | 1973-02-28 |
| BE691641A (en) | 1967-06-22 |
| FI46729C (en) | 1973-06-11 |
| IL27092A (en) | 1970-11-30 |
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