ES338864A1 - PROCEDURE FOR THE PRODUCTION OF THIOXANT DERIVATIVES- NO. - Google Patents
PROCEDURE FOR THE PRODUCTION OF THIOXANT DERIVATIVES- NO.Info
- Publication number
- ES338864A1 ES338864A1 ES338864A ES338864A ES338864A1 ES 338864 A1 ES338864 A1 ES 338864A1 ES 338864 A ES338864 A ES 338864A ES 338864 A ES338864 A ES 338864A ES 338864 A1 ES338864 A1 ES 338864A1
- Authority
- ES
- Spain
- Prior art keywords
- oxidation
- compounds
- pyrrolidinyl
- thioxant
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000003647 oxidation Effects 0.000 abstract 3
- 238000007254 oxidation reaction Methods 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- MOVIWRRLWKNBSH-UHFFFAOYSA-N 10-oxo-9-pyrrolidin-1-ylthioxanthen-9-ol Chemical compound N1(CCCC1)C1(C2=CC=CC=C2S(C=2C=CC=CC12)=O)O MOVIWRRLWKNBSH-UHFFFAOYSA-N 0.000 abstract 1
- RVYXWXQUSFFSER-UHFFFAOYSA-N 2-thioxanthen-9-ylidenepyrrolidine Chemical compound N1C(CCC1)=C1C2=CC=CC=C2SC=2C=CC=CC12 RVYXWXQUSFFSER-UHFFFAOYSA-N 0.000 abstract 1
- SLQQPERIZYXTEG-UHFFFAOYSA-N 9-pyrrolidin-1-ylthioxanthen-9-ol Chemical compound N1(CCCC1)C1(C2=CC=CC=C2SC=2C=CC=CC12)O SLQQPERIZYXTEG-UHFFFAOYSA-N 0.000 abstract 1
- 239000003929 acidic solution Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel compounds I (including acid addition salts thereof), wherein R is an alkyl radical (C 1 -C 4 ) and n is 1 or 2 are prepared: (i) (n is 1) by oxidation of the corresponding 9-pyrrolidinylidenethioxanthene or by oxidation in a neutral or slightly acidic solution of a 9 - pyrrolidinyl - 9 - hydroxythioxanthene (proceeds via an intermediate 9-pyrrolidinyl-9- hydroxy - thioxanthene - 10 - oxide) and (ii) (n is 2) by oxidation in a strongly acid solution of any of the above compounds including compounds I wherein n is 1. Pharmaceutical compositions having an antidepressant activity contain as active ingredient compounds I and are administered enterally or parenterally.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH505566A CH475281A (en) | 1966-04-06 | 1966-04-06 | Process for the preparation of new thioxanthene-10-oxide derivatives |
| CH366966A CH484938A (en) | 1966-04-06 | 1966-04-06 | Process for the preparation of new thioxanthene-10-oxide derivatives |
| CH505666A CH478837A (en) | 1966-04-06 | 1966-04-06 | Process for the preparation of new thioxanthene-10,10-dioxide derivatives |
| CH94167 | 1967-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES338864A1 true ES338864A1 (en) | 1968-08-16 |
Family
ID=27428032
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES338864A Expired ES338864A1 (en) | 1966-04-06 | 1967-04-04 | PROCEDURE FOR THE PRODUCTION OF THIOXANT DERIVATIVES- NO. |
| ES338863A Expired ES338863A1 (en) | 1966-04-06 | 1967-04-04 | Thioxanthene Oxides |
| ES342359A Expired ES342359A1 (en) | 1966-04-06 | 1967-06-27 | Thioxanthene Oxides |
| ES343527A Expired ES343527A1 (en) | 1966-04-06 | 1967-07-28 | Thioxanthene Oxides |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES338863A Expired ES338863A1 (en) | 1966-04-06 | 1967-04-04 | Thioxanthene Oxides |
| ES342359A Expired ES342359A1 (en) | 1966-04-06 | 1967-06-27 | Thioxanthene Oxides |
| ES343527A Expired ES343527A1 (en) | 1966-04-06 | 1967-07-28 | Thioxanthene Oxides |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE696586A (en) |
| CH (3) | CH484938A (en) |
| DE (1) | DE1695708A1 (en) |
| ES (4) | ES338864A1 (en) |
| FR (1) | FR6643M (en) |
| GB (1) | GB1169819A (en) |
| NL (1) | NL6704656A (en) |
| SE (1) | SE327401B (en) |
-
1966
- 1966-04-06 CH CH366966A patent/CH484938A/en not_active IP Right Cessation
- 1966-04-06 CH CH505666A patent/CH478837A/en not_active IP Right Cessation
- 1966-04-06 CH CH505566A patent/CH475281A/en not_active IP Right Cessation
-
1967
- 1967-03-16 GB GB02312/67A patent/GB1169819A/en not_active Expired
- 1967-03-31 NL NL6704656A patent/NL6704656A/xx unknown
- 1967-04-04 BE BE696586D patent/BE696586A/xx unknown
- 1967-04-04 ES ES338864A patent/ES338864A1/en not_active Expired
- 1967-04-04 ES ES338863A patent/ES338863A1/en not_active Expired
- 1967-04-05 SE SE04728/67A patent/SE327401B/xx unknown
- 1967-04-05 DE DE19671695708 patent/DE1695708A1/en active Pending
- 1967-06-27 ES ES342359A patent/ES342359A1/en not_active Expired
- 1967-07-03 FR FR112821A patent/FR6643M/fr not_active Expired
- 1967-07-28 ES ES343527A patent/ES343527A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1695708A1 (en) | 1971-04-22 |
| GB1169819A (en) | 1969-11-05 |
| CH475281A (en) | 1969-07-15 |
| ES342359A1 (en) | 1968-11-01 |
| SE327401B (en) | 1970-08-24 |
| BE696586A (en) | 1967-10-04 |
| FR6643M (en) | 1969-01-20 |
| ES343527A1 (en) | 1968-12-01 |
| NL6704656A (en) | 1967-10-09 |
| CH484938A (en) | 1970-01-31 |
| ES338863A1 (en) | 1968-08-16 |
| CH478837A (en) | 1969-09-30 |
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