ES340130A1 - Procedimiento para la produccion de penicilinas semisinte- ticas. - Google Patents

Procedimiento para la produccion de penicilinas semisinte- ticas.

Info

Publication number: ES340130A1
Authority: ES; Spain
Prior art keywords: penicillin; apa; solvent; micro; hydrolysis
Prior art date: 1967-03-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES340130A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxochem SpA

Original Assignee

Ankerfarm SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1967-03-08

Filing date

1967-05-03

Publication date

1968-08-16

1967-05-03 Application filed by Ankerfarm SpA filed Critical Ankerfarm SpA

1968-08-16 Publication of ES340130A1 publication Critical patent/ES340130A1/es

Status Expired legal-status Critical Current

Links

229930182555 Penicillin Natural products 0.000 title abstract 7
150000002960 penicillins Chemical class 0.000 title 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 10
229940049954 penicillin Drugs 0.000 abstract 6
NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 5
NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 4
LCPDWSOZIOUXRV-UHFFFAOYSA-N phenoxyacetic acid Chemical compound OC(=O)COC1=CC=CC=C1 LCPDWSOZIOUXRV-UHFFFAOYSA-N 0.000 abstract 4
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 4
239000002904 solvent Substances 0.000 abstract 4
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
244000005700 microbiome Species 0.000 abstract 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
230000007062 hydrolysis Effects 0.000 abstract 2
238000006460 hydrolysis reaction Methods 0.000 abstract 2
239000012535 impurity Substances 0.000 abstract 2
235000019371 penicillin G benzathine Nutrition 0.000 abstract 2
229940056360 penicillin g Drugs 0.000 abstract 2
229960003424 phenylacetic acid Drugs 0.000 abstract 2
239000003279 phenylacetic acid Substances 0.000 abstract 2
239000000243 solution Substances 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
241000588724 Escherichia coli Species 0.000 abstract 1
108010073038 Penicillin Amidase Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
239000003957 anion exchange resin Substances 0.000 abstract 1
239000008346 aqueous phase Substances 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
239000007900 aqueous suspension Substances 0.000 abstract 1
229920001429 chelating resin Polymers 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000007071 enzymatic hydrolysis Effects 0.000 abstract 1
238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 1
239000000284 extract Substances 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ES340130A 1967-03-08 1967-05-03 Procedimiento para la produccion de penicilinas semisinte- ticas. Expired ES340130A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1345267		1967-03-08

Publications (1)

Publication Number	Publication Date
ES340130A1 true ES340130A1 (es)	1968-08-16

Family

ID=11144455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES340130A Expired ES340130A1 (es)	1967-03-08	1967-05-03	Procedimiento para la produccion de penicilinas semisinte- ticas.

Country Status (6)

Country	Link
AT (1)	AT284336B (it)
CH (1)	CH529787A (it)
DE (1)	DE1670024A1 (it)
ES (1)	ES340130A1 (it)
GB (1)	GB1212551A (it)
NL (1)	NL6705787A (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2528622A1 (de)	1975-06-26	1977-01-13	Bayer Ag	Verfahren zur reinigung der bei der enzymatischen spaltung von beta-lactam- antibiotika anfallenden produkte
JPS5576886A (en) *	1978-12-07	1980-06-10	Mitsubishi Chem Ind Ltd	Synthetic method of penicillin
ES2105988B1 (es) *	1996-03-15	1998-07-01	Antibioticos Sa	Procedimiento para purificar 7-sustituido-amino-desacetoxi-cefalosporinas mediante el empleo de membranas de filtracion.
ES2105989B1 (es) *	1996-03-15	1998-07-01	Antibioticos Sa	Procedimiento alternativo para la obtencion del acido 6-amino penicilanico (6-apa).

1967
- 1967-04-25 NL NL6705787A patent/NL6705787A/xx unknown
- 1967-05-03 ES ES340130A patent/ES340130A1/es not_active Expired
1968
- 1968-01-12 CH CH46268A patent/CH529787A/it not_active IP Right Cessation
- 1968-02-08 DE DE19681670024 patent/DE1670024A1/de active Pending
- 1968-02-28 AT AT193568A patent/AT284336B/de not_active IP Right Cessation
- 1968-03-08 GB GB01530/68A patent/GB1212551A/en not_active Expired

Also Published As

Publication number	Publication date
GB1212551A (en)	1970-11-18
CH529787A (it)	1972-10-31
DE1670024A1 (de)	1971-02-25
NL6705787A (it)	1968-09-09
AT284336B (de)	1970-09-10

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