ES340132A1 - Ampicillin trihydrate - Google Patents
Ampicillin trihydrateInfo
- Publication number
- ES340132A1 ES340132A1 ES340132A ES340132A ES340132A1 ES 340132 A1 ES340132 A1 ES 340132A1 ES 340132 A ES340132 A ES 340132A ES 340132 A ES340132 A ES 340132A ES 340132 A1 ES340132 A1 ES 340132A1
- Authority
- ES
- Spain
- Prior art keywords
- ampicillin
- water
- trihydrate
- produce
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 title abstract 5
- 229960003311 ampicillin trihydrate Drugs 0.000 title abstract 3
- 229960000723 ampicillin Drugs 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- RXDALBZNGVATNY-CWLIKTDRSA-N ampicillin trihydrate Chemical compound O.O.O.C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 RXDALBZNGVATNY-CWLIKTDRSA-N 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003495 polar organic solvent Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 150000004684 trihydrates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ampicillin trihydrate is prepared by precipitating ampicillin in the form of a hydrate thereof containing at least one but less than three molecules of water per molecule of ampicillin from a solution of ampicillin in an aqueous water-miscible polar organic solvent medium, said medium containing up to 20% by volume of water and subsequently treating the resulting precipitate with an excess of water to produce ampicillin trihydrate. Ampicillin may be dissolved in aqueous acetone at pH 1 to 4, clarified and an inorganic or organic base added to pH 4 to 7 until a precipitate forms. This is washed with an organic solvent and then treated with excess water in order to produce the trihydrate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1345067 | 1967-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES340132A1 true ES340132A1 (en) | 1968-08-16 |
Family
ID=11144453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES340132A Expired ES340132A1 (en) | 1967-03-08 | 1967-05-03 | Ampicillin trihydrate |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT287192B (en) |
| DE (1) | DE1645980A1 (en) |
| DK (1) | DK119979B (en) |
| ES (1) | ES340132A1 (en) |
| FR (1) | FR1557644A (en) |
| GB (1) | GB1216714A (en) |
| GR (1) | GR37429B (en) |
| NL (1) | NL6705789A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3703511A (en) * | 1969-06-06 | 1972-11-21 | Squibb & Sons Inc | Alpha-aminobenzyl penicillins |
| JPS6379888A (en) * | 1986-09-24 | 1988-04-09 | Tanabe Seiyaku Co Ltd | Stable hydrate of penicillin derivative |
| AR062927A1 (en) | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4- ([[4- CHLORINE-3- (TRIFLUOROMETILE) PHENYL) CARBAMOIL] AMINO] -3- FLUOROPHENOXY) -N- METHYLPIRIDIN-2-MONOHIDRATED CARBOXAMIDE |
-
1967
- 1967-04-25 NL NL6705789A patent/NL6705789A/xx unknown
- 1967-05-03 ES ES340132A patent/ES340132A1/en not_active Expired
- 1967-06-21 DE DE19671645980 patent/DE1645980A1/en active Pending
- 1967-06-22 FR FR1557644D patent/FR1557644A/fr not_active Expired
- 1967-06-26 GR GR670137429A patent/GR37429B/en unknown
-
1968
- 1968-02-28 AT AT193368A patent/AT287192B/en not_active IP Right Cessation
- 1968-03-07 DK DK95068A patent/DK119979B/en unknown
- 1968-03-08 GB GB1152868A patent/GB1216714A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1645980A1 (en) | 1970-07-16 |
| FR1557644A (en) | 1969-02-21 |
| NL6705789A (en) | 1968-09-09 |
| DK119979B (en) | 1971-03-22 |
| GR37429B (en) | 1969-05-29 |
| GB1216714A (en) | 1970-12-23 |
| AT287192B (en) | 1971-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1302537A (en) | ||
| ES340132A1 (en) | Ampicillin trihydrate | |
| AT274349B (en) | Process for the preparation of aqueous solutions containing high molecular weight polyacrylamide and sodium polyacrylate | |
| ES312167A1 (en) | A procedure to electrolytically attack an aluminum sheet. (Machine-translation by Google Translate, not legally binding) | |
| ES348097A1 (en) | Process for the production of an intramuscularly injectable iron preparation for animals | |
| GB1152506A (en) | A process for the manufacture of Enriched Colloidal Silver | |
| ES300658A1 (en) | Procedure for the production of a new polipepturo (Machine-translation by Google Translate, not legally binding) | |
| KR890014583A (en) | Method for producing latex based on polypyrrole and use of the latex to form conductive films | |
| ES311666A1 (en) | Procedure for the obtaining of a salt 4: 4'-bipiridilio, n: n'disustituida. (Machine-translation by Google Translate, not legally binding) | |
| SE308902B (en) | ||
| GB1225599A (en) | ||
| GB830011A (en) | Improvements in and relating to the polymerisation of vinyl compounds | |
| GB974128A (en) | Kanamycin complex salts | |
| GB1156738A (en) | Printing and Dyeing Processes | |
| GB1251761A (en) | ||
| ES326196A3 (en) | Procedure for the production of acrylonitryl polymers. (Machine-translation by Google Translate, not legally binding) | |
| ES296050A1 (en) | A procedure to produce bright nickel deposits (Machine-translation by Google Translate, not legally binding) | |
| GB1237309A (en) | Stabilising aqueous solutions of potassium persulphate | |
| GB1145112A (en) | Edible collagen sausage casing | |
| ES380448A1 (en) | Alpha-aminobenzyl penicillins | |
| ES282912A1 (en) | Procedure to produce coloring preparations (Machine-translation by Google Translate, not legally binding) | |
| ES338699A1 (en) | Separation process | |
| ES299426A1 (en) | Procedure for obtaining new derivatives of bio and semisynthetic penicillines (Machine-translation by Google Translate, not legally binding) | |
| ES326947A1 (en) | Procedure for industrial preparation of hydroxocobalinin by reducing the cyancobalamine in solution following its oxidation. (Machine-translation by Google Translate, not legally binding) | |
| GB1427242A (en) | Production of auramine salts and auramine salt solutions |