ES340257A1 - 00,11-Dihydro-5H-Dibenzo[a,d]Cycloheptene Derivatives - Google Patents
00,11-Dihydro-5H-Dibenzo[a,d]Cycloheptene DerivativesInfo
- Publication number
- ES340257A1 ES340257A1 ES340257A ES340257A ES340257A1 ES 340257 A1 ES340257 A1 ES 340257A1 ES 340257 A ES340257 A ES 340257A ES 340257 A ES340257 A ES 340257A ES 340257 A1 ES340257 A1 ES 340257A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- formula
- subjected
- alkenyl
- alkynyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005741 alkyl alkenyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 238000005905 alkynylation reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000006894 reductive elimination reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Novel compounds of general formula wherein R 1 is H or C 1-3 alkyl, R 2 is a C 1-3 alkyl, alkenyl or alkynyl group, R 3 is C 1-3 alkyl and one of R 4 and R 5 is H and the other is H, halogen or C 1-3 alkyl, and acid addition salts thereof are prepared by one of the following methods (a) a reactive ester of an alcohol of formula is reacted with an amine of formula H.N.R 2 R 3 (b) a compound of formula wherein R1 is H or a C 1-3 alkyl alkenyl or alkynyl group is subjected to alkylation, alkenylation or alkynylation or (c) a quaternary salt of formula wherein X is an acid radical is subjected to reductive cleavage, all of which may be followed by salt formation. Pharmaceutical compositions in conventional forms for enteral or parenteral administration and having anticonvulsant activity comprise an above novel compound and a carrier therefor. Reference has been directed by the Comptroller to Specification 1,115,327.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH678166A CH473759A (en) | 1966-05-10 | 1966-05-10 | Process for the preparation of 10,11-dihydro-5H-dibenzo (a, d) -cycloheptene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES340257A1 true ES340257A1 (en) | 1968-09-01 |
Family
ID=4314928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES340257A Expired ES340257A1 (en) | 1966-05-10 | 1967-05-08 | 00,11-Dihydro-5H-Dibenzo[a,d]Cycloheptene Derivatives |
Country Status (12)
| Country | Link |
|---|---|
| AT (3) | AT283311B (en) |
| BE (1) | BE698198A (en) |
| CH (3) | CH473759A (en) |
| CS (4) | CS154230B2 (en) |
| DE (1) | DE1643212A1 (en) |
| ES (1) | ES340257A1 (en) |
| FI (1) | FI47348C (en) |
| FR (1) | FR6502M (en) |
| GB (1) | GB1170798A (en) |
| GR (1) | GR36291B (en) |
| NL (1) | NL6706480A (en) |
| NO (1) | NO122246B (en) |
-
1966
- 1966-05-10 CH CH678166A patent/CH473759A/en not_active IP Right Cessation
- 1966-05-10 CH CH1716868A patent/CH481055A/en not_active IP Right Cessation
- 1966-05-10 CH CH1716968A patent/CH481869A/en not_active IP Right Cessation
-
1967
- 1967-05-03 DE DE19671643212 patent/DE1643212A1/en active Pending
- 1967-05-03 FI FI671285A patent/FI47348C/en active
- 1967-05-05 GB GB20979/67A patent/GB1170798A/en not_active Expired
- 1967-05-08 GR GR670136291A patent/GR36291B/en unknown
- 1967-05-08 ES ES340257A patent/ES340257A1/en not_active Expired
- 1967-05-09 NO NO168071A patent/NO122246B/no unknown
- 1967-05-09 AT AT870569A patent/AT283311B/en not_active IP Right Cessation
- 1967-05-09 NL NL6706480A patent/NL6706480A/xx unknown
- 1967-05-09 AT AT434967A patent/AT283303B/en not_active IP Right Cessation
- 1967-05-09 BE BE698198D patent/BE698198A/xx unknown
- 1967-05-09 AT AT870769A patent/AT283312B/en not_active IP Right Cessation
- 1967-05-10 CS CS281270*1A patent/CS154230B2/cs unknown
- 1967-05-10 CS CS281370*1A patent/CS154231B2/cs unknown
- 1967-05-10 CS CS337867A patent/CS154228B2/cs unknown
- 1967-05-10 FR FR105888A patent/FR6502M/fr not_active Expired
- 1967-05-10 CS CS281170*1A patent/CS154229B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT283311B (en) | 1970-08-10 |
| DE1643212A1 (en) | 1971-03-11 |
| CS154231B2 (en) | 1974-03-29 |
| CS154228B2 (en) | 1974-03-29 |
| GR36291B (en) | 1969-01-20 |
| CS154230B2 (en) | 1974-03-29 |
| NL6706480A (en) | 1967-11-13 |
| CS154229B2 (en) | 1974-03-29 |
| AT283303B (en) | 1970-08-10 |
| CH473759A (en) | 1969-06-15 |
| GB1170798A (en) | 1969-11-19 |
| BE698198A (en) | 1967-11-09 |
| CH481869A (en) | 1969-11-30 |
| FI47348C (en) | 1973-11-12 |
| AT283312B (en) | 1970-08-10 |
| CH481055A (en) | 1969-11-15 |
| FI47348B (en) | 1973-07-31 |
| FR6502M (en) | 1968-12-02 |
| NO122246B (en) | 1971-06-07 |
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