ES340648A2 - A PROCEDURE FOR OBTAINING NEW 2-AMINO-HALO-GENO-BENZYLAMINES. - Google Patents
A PROCEDURE FOR OBTAINING NEW 2-AMINO-HALO-GENO-BENZYLAMINES.Info
- Publication number
- ES340648A2 ES340648A2 ES340648A ES340648A ES340648A2 ES 340648 A2 ES340648 A2 ES 340648A2 ES 340648 A ES340648 A ES 340648A ES 340648 A ES340648 A ES 340648A ES 340648 A2 ES340648 A2 ES 340648A2
- Authority
- ES
- Spain
- Prior art keywords
- groups
- group
- formula
- substituted
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003158 alcohol group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- -1 nitro, carboxy Chemical group 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 235000005985 organic acids Nutrition 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical class N1(CCOCC1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Improvements introduced in the object of the main patent No. 327,566 by: A process for obtaining new 2-amino-halogen-benzylamines of the formula **(See formula)** in which Hal represents a chlorine or bromine atom in position 3, 4, 5 or 6, and R1 represents a hydrogen or halogen atom, represented R2 hydrogen, a straight or branched alcoholic or alkenyl group, a hydroxyalkyl, alkoxyalkoxy, dialkoxylamino alcohol or cycloalkoxy group, an aryl group which can be substituted by a halogen atom, an alcohol, alkoxy, nitro, carboxy or carbalkoxy group, a group aralkoxy, pyridyl or pyridylalkyl, groups which can be substituted by halogen atoms or by alcohol or alkoxy groups, and representing. R3 is a hydroxy or alkoxy group, an amino group which may be unsubstituted or substituted by branched or straight-chain lower alcohol groups, by hydroxyalkyl, alkoxy, alcohol, cycloalkyl, alkenyl, dialkoxylaminoalcohyl or aryl groups, or aryl, aralcoyl groups, or halogen-substituted pyridyl, all of which may be the same or different, or a pyrrolidine, piperidine, piperazine, morpholino or hexamethylenimino nucleus, which may be substituted by lower alcohol groups, R4 and R5 which may be the same or different, represent hydrogen or acyl groups, and n represents a number from 1 to 3. and of its pharmaceutically tolerable salts with inorganic or organic acids or bases, characterized by reacting a 2-acylamino-halogen-benzylhalogenide of the formula **(See formula)** in which the Hal groups, which may be the same or different, represent chlorine or bromine atoms, R1 has the meaning indicated above and Ac represents any aliphatic, araliphatic or aromatic acyl group, with an aminocarboxylic acid of the formula **(See formula)** in which R2, R3 and n have the meaning indicated above, in the presence of a fixing agent for halogenated acids, preferably in the presence of an inert solvent and preferably at elevated temperatures, and to obtain an acid addition salt, reacting the compound obtained from formula I with inorganic and organic acids by known methods. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT273081D | |||
| DET0031195 | 1966-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES340648A2 true ES340648A2 (en) | 1968-06-01 |
Family
ID=25608208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES340648A Expired ES340648A2 (en) | 1966-05-20 | 1967-05-17 | A PROCEDURE FOR OBTAINING NEW 2-AMINO-HALO-GENO-BENZYLAMINES. |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT278754B (en) |
| CH (1) | CH520656A (en) |
| DE (1) | DE1543923A1 (en) |
| DK (1) | DK131852C (en) |
| ES (1) | ES340648A2 (en) |
| FI (1) | FI46839C (en) |
| NL (1) | NL150431B (en) |
| SE (1) | SE356503B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2171073A1 (en) * | 1995-12-04 | 1997-06-05 | Philip C. Lang | Process for the preparation of ethyl-n-(2,3 dichloro-6- nitrobenzyl) glycine |
-
1966
- 1966-05-20 DE DE19661543923 patent/DE1543923A1/en active Pending
-
1967
- 1967-05-17 ES ES340648A patent/ES340648A2/en not_active Expired
- 1967-05-18 CH CH699267A patent/CH520656A/en not_active IP Right Cessation
- 1967-05-18 SE SE699067A patent/SE356503B/xx unknown
- 1967-05-19 FI FI142967A patent/FI46839C/en active
- 1967-05-19 AT AT472867A patent/AT278754B/en not_active IP Right Cessation
- 1967-05-19 NL NL6706993A patent/NL150431B/en unknown
- 1967-05-19 DK DK262967A patent/DK131852C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| NL6706993A (en) | 1967-11-21 |
| AT278754B (en) | 1970-02-10 |
| FI46839C (en) | 1973-07-10 |
| CH520656A (en) | 1972-03-31 |
| FI46839B (en) | 1973-04-02 |
| DE1543923A1 (en) | 1970-02-05 |
| SE356503B (en) | 1973-05-28 |
| DK131852B (en) | 1975-09-15 |
| DK131852C (en) | 1976-03-15 |
| NL150431B (en) | 1976-08-16 |
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