ES342062A1 - Procedimiento para la produccion de 1-fenil-2-aminoetano. - Google Patents

Procedimiento para la produccion de 1-fenil-2-aminoetano.

Info

Publication number: ES342062A1
Authority: ES; Spain
Prior art keywords: formula; alkyl; chlorophenyl; compounds; ethyl
Prior art date: 1966-06-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES342062A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CH Boehringer Sohn AG and Co KG

Original Assignee

CH Boehringer Sohn AG and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-06-23

Filing date

1967-06-20

Publication date

1968-07-16

1967-06-20 Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG

1968-07-16 Publication of ES342062A1 publication Critical patent/ES342062A1/es

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 abstract 10
125000000217 alkyl group Chemical group 0.000 abstract 8
-1 1-(p-chlorophenyl)-2- formylamino - butane 1 - (p - chlorophenyl)- butanone Chemical compound 0.000 abstract 3
JSZOAYXJRCEYSX-UHFFFAOYSA-N 1-nitropropane Chemical compound CCC[N+]([O-])=O JSZOAYXJRCEYSX-UHFFFAOYSA-N 0.000 abstract 3
229910052801 chlorine Inorganic materials 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 2
229910052794 bromium Inorganic materials 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
150000002576 ketones Chemical class 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
IOAJWDUHRZDCAJ-UHFFFAOYSA-N 1,2-dichloro-4-(2-nitrobut-1-enyl)benzene Chemical compound CCC([N+]([O-])=O)=CC1=CC=C(Cl)C(Cl)=C1 IOAJWDUHRZDCAJ-UHFFFAOYSA-N 0.000 abstract 1
SOBINWSGYXRJND-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-(methylamino)pent-1-en-1-ol Chemical compound ClC1=CC=C(C=C1)C(=C(CCC)NC)O SOBINWSGYXRJND-UHFFFAOYSA-N 0.000 abstract 1
HAELFEDVTLKJMU-UHFFFAOYSA-N 1-(4-chlorophenyl)butan-1-ol Chemical compound CCCC(O)C1=CC=C(Cl)C=C1 HAELFEDVTLKJMU-UHFFFAOYSA-N 0.000 abstract 1
JQZAEUFPPSRDOP-UHFFFAOYSA-N 1-chloro-4-(chloromethyl)benzene Chemical group ClCC1=CC=C(Cl)C=C1 JQZAEUFPPSRDOP-UHFFFAOYSA-N 0.000 abstract 1
QNZGBKFZLKIUPN-UHFFFAOYSA-N 2-[(4-chlorophenyl)methyl]propanedioic acid Chemical compound OC(=O)C(C(O)=O)CC1=CC=C(Cl)C=C1 QNZGBKFZLKIUPN-UHFFFAOYSA-N 0.000 abstract 1
DMIIFTRCIMNYKZ-UHFFFAOYSA-N 2-[1-(4-chlorophenyl)butan-2-yl]isoindole-1,3-dione Chemical compound ClC1=CC=C(C=C1)CC(CC)N1C(C=2C(C1=O)=CC=CC2)=O DMIIFTRCIMNYKZ-UHFFFAOYSA-N 0.000 abstract 1
KMGUEILFFWDGFV-UHFFFAOYSA-N 2-benzoyl-2-benzoyloxy-3-hydroxybutanedioic acid Chemical compound C=1C=CC=CC=1C(=O)C(C(C(O)=O)O)(C(O)=O)OC(=O)C1=CC=CC=C1 KMGUEILFFWDGFV-UHFFFAOYSA-N 0.000 abstract 1
MJFYJSUVLVMOOX-UHFFFAOYSA-N 2-benzyl-1-(4-chlorophenyl)-2-(methylamino)pentan-1-one Chemical compound ClC1=CC=C(C=C1)C(C(CCC)(CC1=CC=CC=C1)NC)=O MJFYJSUVLVMOOX-UHFFFAOYSA-N 0.000 abstract 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
AVPYQKSLYISFPO-UHFFFAOYSA-N 4-chlorobenzaldehyde Chemical compound ClC1=CC=C(C=O)C=C1 AVPYQKSLYISFPO-UHFFFAOYSA-N 0.000 abstract 1
UOQXIWFBQSVDPP-UHFFFAOYSA-N 4-fluorobenzaldehyde Chemical compound FC1=CC=C(C=O)C=C1 UOQXIWFBQSVDPP-UHFFFAOYSA-N 0.000 abstract 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 abstract 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
ZWEHNKRNPOVVGH-UHFFFAOYSA-N Methyl ethyl ketone Natural products CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
LRVYGDGSWJYKNH-UHFFFAOYSA-N bromoethane 3-[1-(4-chlorophenyl)propoxy]-3-oxopropanoic acid Chemical compound C(CC(=O)O)(=O)OC(C1=CC=C(C=C1)Cl)CC.C(C)Br LRVYGDGSWJYKNH-UHFFFAOYSA-N 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
238000005660 chlorination reaction Methods 0.000 abstract 1
238000007796 conventional method Methods 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
238000001640 fractional crystallisation Methods 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
RIWRFSMVIUAEBX-UHFFFAOYSA-N n-methyl-1-phenylmethanamine Chemical compound CNCC1=CC=CC=C1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
235000002906 tartaric acid Nutrition 0.000 abstract 1
239000011975 tartaric acid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ES342062A 1966-06-23 1967-06-20 Procedimiento para la produccion de 1-fenil-2-aminoetano. Expired ES342062A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DEB0087689		1966-06-23
DEB0088652		1966-08-26

Publications (1)

Publication Number	Publication Date
ES342062A1 true ES342062A1 (es)	1968-07-16

Family

ID=25967949

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES342062A Expired ES342062A1 (es)	1966-06-23	1967-06-20	Procedimiento para la produccion de 1-fenil-2-aminoetano.

Country Status (6)

Country	Link
AT (1)	AT286259B (de)
BE (1)	BE700459A (de)
ES (1)	ES342062A1 (de)
FR (1)	FR7510M (de)
GB (1)	GB1192223A (de)
NL (1)	NL6708305A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2239012A1 (de) *	1972-08-08	1974-02-21	Knoll Ag	Basisch substituierte theophyllinabkoemmlinge

1967
- 1967-06-15 NL NL6708305A patent/NL6708305A/xx unknown
- 1967-06-20 ES ES342062A patent/ES342062A1/es not_active Expired
- 1967-06-23 BE BE700459D patent/BE700459A/xx unknown
- 1967-06-23 GB GB29217/67A patent/GB1192223A/en not_active Expired
- 1967-06-23 AT AT589167A patent/AT286259B/de not_active IP Right Cessation
- 1967-09-22 FR FR121987A patent/FR7510M/fr not_active Expired

Also Published As

Publication number	Publication date
NL6708305A (de)	1967-12-27
AT286259B (de)	1970-12-10
GB1192223A (en)	1970-05-20
FR7510M (de)	1969-12-15
BE700459A (de)	1967-12-27

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GB1164192A (en)	1969-09-17	Tetrahydroisoquinolines and process for preparing them
Zweifel et al.	1972	Convenient synthesis of trans olefins from alkynes via hydroboration-cyanohalogenation
HUT59376A (en)	1992-05-28	Process for producing r(+)-n-propargyl-1-aminoindane and pharmaceutical compositions comprising such compound
DD143607A5 (de)	1980-09-03	Verfahren zur herstellung neuer carbazolyl-(4)-oxy-propanolamin-derivate
GB1180749A (en)	1970-02-11	A New Polycyclic Amine and Processes for its Production
GB1341375A (en)	1973-12-19	Aminoalkylimidazoles and process for their production
US3536713A (en)	1970-10-27	N-(hydroxy-cyclohexyl)-aminobenzylamines and the salts thereof
AU609748B2 (en)	1991-05-09	Process for preparing mono-, bi- and tricyclic amino acids, intermediates of this process, and a process for preparing same
DE3223463A1 (de)	1983-05-05	Substituierte 3-azabicyclo(3.1.0)hexane und verfahren zur behandlung von depressionen unter verwendung von substituierten 3-azabicyclo(3.1.0)hexanen
ES346521A1 (es)	1969-03-16	Un procedimiento para la preparacion de derivados de sulfo-nilurea.
GB1152895A (en)	1969-05-21	Novel Phenylalanine Derivatives and a process for the manufacture thereof
US4131745A (en)	1978-12-26	Aryloxy aminobutanols, their preparation and use thereof
ES435498A1 (es)	1976-12-01	Procedimiento para la preparacion de 1-(3,5-dihidroxifenil)-1-hidroxi-2-(1-metil-2-(4-hidroxifenil)-etil)-aminoetano.
US2945877A (en)	1960-07-19	Carbamic acid esters of 2, 4, 5-trichlorophenol
GB1192223A (en)	1970-05-20	0-Phenyl-2-Amino Ethanes and Derivatives
IE41652L (en)	1976-05-01	Amines having cardiac activity
US3846476A (en)	1974-11-05	N-benzyloxycarbonyl-dopa derivatives
US4146645A (en)	1979-03-27	Hypertensive phenylalkylamines and salts thereof
US3388164A (en)	1968-06-11	Method of preparing 1-adamantanamine
GB1444717A (en)	1976-08-04	Bicycloalkyl derivatives
US3513199A (en)	1970-05-19	Substituted anilino benzyl alcohols
US3994914A (en)	1976-11-30	4,4-Substituted-oxazolinium halides
US3101367A (en)	1963-08-20	alpha-amino-beta-hydroxycarboxylic acid amides
SU741792A3 (ru)	1980-06-15	Способ получени производных -/втор-амино/-о-нитробутирофенона или его солей
US3996383A (en)	1976-12-07	3-Alkylamino-α-aminomethyl-4-hydroxybenzyl alcohols with β-adrenergic stimulant activity