ES347318A1 - Procedimiento para la preparacion de nuevos nitro-estra- trienos. - Google Patents
Procedimiento para la preparacion de nuevos nitro-estra- trienos.Info
- Publication number
- ES347318A1 ES347318A1 ES347318A ES347318A ES347318A1 ES 347318 A1 ES347318 A1 ES 347318A1 ES 347318 A ES347318 A ES 347318A ES 347318 A ES347318 A ES 347318A ES 347318 A1 ES347318 A1 ES 347318A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- hydrogen
- compound
- aliphatic
- estratrienes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZXMMFDHZJQEMIN-MUSFGAPCSA-N (9R,10S,13S)-13-(nitromethyl)-1,2,3,4,5,6,9,10,11,12-decahydrocyclopenta[a]phenanthrene Chemical class [N+](=O)([O-])C[C@@]12C=CC=C1C1=CCC3CCCC[C@@H]3[C@H]1CC2 ZXMMFDHZJQEMIN-MUSFGAPCSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000002513 anti-ovulatory effect Effects 0.000 abstract 1
- 230000002054 antogonadotrophic effect Effects 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 230000033444 hydroxylation Effects 0.000 abstract 1
- 238000005805 hydroxylation reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Manufacture And Refinement Of Metals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT3007766 | 1966-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES347318A1 true ES347318A1 (es) | 1969-02-01 |
Family
ID=11228982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES347318A Expired ES347318A1 (es) | 1966-11-18 | 1967-11-17 | Procedimiento para la preparacion de nuevos nitro-estra- trienos. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3520909A (es) |
| AT (1) | AT271757B (es) |
| BE (1) | BE706686A (es) |
| CH (1) | CH493506A (es) |
| DE (1) | DE1618977B1 (es) |
| DK (1) | DK116659B (es) |
| ES (1) | ES347318A1 (es) |
| FR (1) | FR7064M (es) |
| GB (1) | GB1145437A (es) |
| GR (1) | GR38947B (es) |
| IL (1) | IL28936A (es) |
| NL (2) | NL6715106A (es) |
| NO (1) | NO128023B (es) |
| SE (1) | SE335527B (es) |
| YU (1) | YU31806B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554603A (en) * | 1993-09-17 | 1996-09-10 | The United States Of America As Represented By The Department Of Health And Human Services | Orally active derivatives of 1,3,5(10)-estratriene |
-
0
- NL NL135316D patent/NL135316C/xx active
-
1967
- 1967-11-07 NL NL6715106A patent/NL6715106A/xx unknown
- 1967-11-13 IL IL28936A patent/IL28936A/en unknown
- 1967-11-13 DE DE1967S0112800 patent/DE1618977B1/de not_active Withdrawn
- 1967-11-14 AT AT1024767A patent/AT271757B/de active
- 1967-11-14 FR FR128076A patent/FR7064M/fr not_active Expired
- 1967-11-14 GB GB51714/67A patent/GB1145437A/en not_active Expired
- 1967-11-15 YU YU2225/67A patent/YU31806B/xx unknown
- 1967-11-15 DK DK569867AA patent/DK116659B/da unknown
- 1967-11-17 BE BE706686D patent/BE706686A/xx unknown
- 1967-11-17 NO NO00170574A patent/NO128023B/no unknown
- 1967-11-17 GR GR670138947A patent/GR38947B/el unknown
- 1967-11-17 SE SE15811/67A patent/SE335527B/xx unknown
- 1967-11-17 CH CH1615667A patent/CH493506A/de not_active IP Right Cessation
- 1967-11-17 ES ES347318A patent/ES347318A1/es not_active Expired
-
1969
- 1969-02-28 US US803415*A patent/US3520909A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| YU222567A (en) | 1973-06-30 |
| YU31806B (en) | 1973-12-31 |
| SE335527B (es) | 1971-06-01 |
| NO128023B (es) | 1973-09-17 |
| FR7064M (es) | 1969-06-23 |
| US3520909A (en) | 1970-07-21 |
| IL28936A (en) | 1972-07-26 |
| GB1145437A (en) | 1969-03-12 |
| BE706686A (es) | 1968-05-17 |
| NL6715106A (es) | 1968-05-20 |
| NL135316C (es) | |
| GR38947B (el) | 1970-01-20 |
| CH493506A (de) | 1970-07-15 |
| DE1618977B1 (de) | 1972-07-20 |
| DK116659B (da) | 1970-02-02 |
| AT271757B (de) | 1969-06-10 |
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