ES353393A1 - Procedure for the preparation of oxazinoisoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of oxazinoisoquinoline derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES353393A1 ES353393A1 ES353393A ES353393A ES353393A1 ES 353393 A1 ES353393 A1 ES 353393A1 ES 353393 A ES353393 A ES 353393A ES 353393 A ES353393 A ES 353393A ES 353393 A1 ES353393 A1 ES 353393A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- piperazin
- alkoxy
- och
- oxazinoisoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RXINFAULMRJDAU-UHFFFAOYSA-N 7h-pyrido[3,4-f][2,1]benzoxazine Chemical class C1=CC2=CC=NC=C2C2=C1NOC=C2 RXINFAULMRJDAU-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 morpholino, 1-pyrrolidinyl Chemical group 0.000 abstract 3
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the general formula (R 1 =H, C 1-3 alkoxy R 2 , 3 =C 1-3 alkoxy or (when R 1 =H) R 2+3 =OCH 2 O Am=NH 2 , C 1-3 alkylamino, di-(C 1-3 alkyl)amino, morpholino, 1-pyrrolidinyl, piperidino, 1-piperazinyl, 4- (C 1-3 alkyl)piperazin-l-yl, 4-(3 2-3 -hydroxyalkyl)- piperazin - 1 - yl, 4- (C 1-3 alkoxy - C 2-3 alkyl)- piperazin-l-yl)) and their acid addition salts are prepared by (a) reacting a compound of the formula (X=Cl, Br, C 1-3 alkoxy, OCH 2 CN, OC 6 H 4 NO 2 - (p), C 2-5 alkoxycarbonyl, O.CO.OCH 2 Ph) with HAm or an alkali metal derivative thereof, (b) cyclizing a compound of the formula (Am1=di-(C 1-3 alkyl)amino, morpholino, 1- pyrrolidinyl, piperidino, 4-(C 1-3 alkyl)piperazin- 1-yl) and reducing the product or (c)-when Am=NH 2 -hydrolysing the corresponding hitrile, optionally followed in each case by salt formation and/or isomer separation or resolution. The above compounds are tranquilizers and muscle relaxants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63485667A | 1967-05-01 | 1967-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES353393A1 true ES353393A1 (en) | 1969-09-01 |
Family
ID=24545439
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES353394A Expired ES353394A1 (en) | 1967-05-01 | 1968-04-30 | Procedure for the preparation of oxazinoisoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES353393A Expired ES353393A1 (en) | 1967-05-01 | 1968-04-30 | Procedure for the preparation of oxazinoisoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES353395A Expired ES353395A1 (en) | 1967-05-01 | 1968-04-30 | Procedure for the preparation of oxazinoisoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES353394A Expired ES353394A1 (en) | 1967-05-01 | 1968-04-30 | Procedure for the preparation of oxazinoisoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES353395A Expired ES353395A1 (en) | 1967-05-01 | 1968-04-30 | Procedure for the preparation of oxazinoisoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
| Country | Link |
|---|---|
| AT (3) | AT277273B (en) |
| BE (1) | BE714508A (en) |
| CH (1) | CH499538A (en) |
| DE (1) | DE1770304A1 (en) |
| DK (1) | DK125422B (en) |
| ES (3) | ES353394A1 (en) |
| FR (3) | FR1578899A (en) |
| GB (2) | GB1234625A (en) |
| IE (1) | IE32045B1 (en) |
| IL (1) | IL29920A (en) |
| NL (1) | NL6805805A (en) |
| SE (1) | SE343586B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU191301B (en) * | 1984-03-23 | 1987-02-27 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing 1-/hydroxy-methyl/-1,6,7,11b-tetrahydro-2h,4h-/1,3/-oxazino- or -thiazino/4,3-a/isoquinoline -derivatives |
-
1968
- 1968-04-24 NL NL6805805A patent/NL6805805A/xx unknown
- 1968-04-24 SE SE5540/68A patent/SE343586B/xx unknown
- 1968-04-24 DK DK185068AA patent/DK125422B/en unknown
- 1968-04-30 IL IL29920A patent/IL29920A/en unknown
- 1968-04-30 ES ES353394A patent/ES353394A1/en not_active Expired
- 1968-04-30 IE IE506/68A patent/IE32045B1/en unknown
- 1968-04-30 DE DE19681770304 patent/DE1770304A1/en active Pending
- 1968-04-30 BE BE714508D patent/BE714508A/xx unknown
- 1968-04-30 GB GB1234625D patent/GB1234625A/en not_active Expired
- 1968-04-30 ES ES353393A patent/ES353393A1/en not_active Expired
- 1968-04-30 AT AT00989/69A patent/AT277273B/en active
- 1968-04-30 CH CH638268A patent/CH499538A/en not_active IP Right Cessation
- 1968-04-30 AT AT00988/69A patent/AT277272B/en not_active IP Right Cessation
- 1968-04-30 GB GB1234624D patent/GB1234624A/en not_active Expired
- 1968-04-30 AT AT419468A patent/AT277271B/en not_active IP Right Cessation
- 1968-04-30 ES ES353395A patent/ES353395A1/en not_active Expired
- 1968-05-02 FR FR1578899D patent/FR1578899A/fr not_active Expired
- 1968-07-30 FR FR161146A patent/FR7706M/fr not_active Expired
- 1968-07-30 FR FR161145A patent/FR7645M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL29920A (en) | 1972-04-27 |
| BE714508A (en) | 1968-10-30 |
| IL29920A0 (en) | 1968-06-20 |
| SE343586B (en) | 1972-03-13 |
| GB1234624A (en) | 1971-06-09 |
| AT277271B (en) | 1969-12-29 |
| ES353394A1 (en) | 1969-10-01 |
| ES353395A1 (en) | 1969-10-01 |
| FR7706M (en) | 1970-02-23 |
| DE1770304A1 (en) | 1971-10-21 |
| GB1234625A (en) | 1971-06-09 |
| AT277273B (en) | 1969-12-29 |
| FR7645M (en) | 1970-02-02 |
| AT277272B (en) | 1969-12-29 |
| CH499538A (en) | 1970-11-30 |
| FR1578899A (en) | 1969-08-22 |
| IE32045L (en) | 1968-11-01 |
| DK125422B (en) | 1973-02-19 |
| IE32045B1 (en) | 1973-03-21 |
| NL6805805A (en) | 1968-11-04 |
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