ES355604A1 - Procedure for the preparation of active compounds on the heart and the circulation. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of active compounds on the heart and the circulation. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES355604A1 ES355604A1 ES355604A ES355604A ES355604A1 ES 355604 A1 ES355604 A1 ES 355604A1 ES 355604 A ES355604 A ES 355604A ES 355604 A ES355604 A ES 355604A ES 355604 A1 ES355604 A1 ES 355604A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- compound
- group
- formula
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 11
- 238000000034 method Methods 0.000 title abstract 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- -1 cyano- Chemical class 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000003158 alcohol group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000003868 ammonium compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of active compounds on the heart and circulation of the general formula II **(See formula)** wherein R1 signifies a bromine, fluorine atom, a cyano-, carboxy-, carbalkoxy-lower, alcohol-mercapto-lower, lower-alcohol-sulfonyl, low-molecular-weight, amino or trifluoromethyl group; R2 and R3 signify hydrogen, chlorine, bromine, low molecular weight alcohol groups, hydroxy or low molecular weight alkoxy; R4 signifies hydrogen or a methyl or ethyl radical; R5 means hydrogen or a low molecular weight alcohol radical; R6 signifies hydrogen or a lower alcohol group; R7 signifies hydrogen or a hydroxy group; and R8 and R9 signify hydrogen or halogen atoms or lower alcohol or low molecular weight alkoxy groups, or a hydroxy group, its salts, its quaternary ammonium compounds, as well as its optically active or distereoisomeric isomers, characterized in that, in a manner per se known, a) a compound of the general formula is reacted **(See formula)** with a compound of the general formula **(See formula)** together with formaldehyde or substances that provide formaldehyde; or b) a compound of the general formula is reacted **(See formula)** with a compound of the general formula **(See formula)** in which Z and W are in each case different from each other, and signify a halogen atom or the group -NHR5, in the presence of a basic substance; or c) a compound of the general formula is reacted **(See formula)** or the corresponding Mannich base of the general formula **(See formula)** in which the radicals R1 to R4 have the meanings indicated above and the radicals R10 and R11 represent low molecular weight alcohol radicals, with a compound of the general formula IV; or d) a compound of the general formula is reacted **(See formula)** in which Me means an alkali metal or the radical MgCl, MgBr or Mgl, with a compound of the general formula **(See formula)** where V means a cyano group or the -COHal group (Hal = chlorine or bromine); or e) in a compound of the general formula II, in which R1 signifies a nitro group, this nitro group is selectively reduced to an amino group, and eventually it is transformed to the bases thus obtained into its salts by the addition of acid or ammonium compounds quaternary. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DED0053480 | 1967-06-29 | ||
| DED0053479 | 1967-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES355604A1 true ES355604A1 (en) | 1970-01-01 |
Family
ID=25972588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES355604A Expired ES355604A1 (en) | 1967-06-29 | 1968-06-28 | Procedure for the preparation of active compounds on the heart and the circulation. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| AT (1) | AT280244B (en) |
| ES (1) | ES355604A1 (en) |
-
1968
- 1968-06-25 AT AT495069A patent/AT280244B/en not_active IP Right Cessation
- 1968-06-28 ES ES355604A patent/ES355604A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT280244B (en) | 1970-04-10 |
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