ES361907A1 - Procedure for preparing new benzamidine substitute heterociclic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparing new benzamidine substitute heterociclic compounds. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES361907A1 ES361907A1 ES361907A ES361907A ES361907A1 ES 361907 A1 ES361907 A1 ES 361907A1 ES 361907 A ES361907 A ES 361907A ES 361907 A ES361907 A ES 361907A ES 361907 A1 ES361907 A1 ES 361907A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- salt
- substitute
- translation
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000006606 n-butoxy group Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
-
- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04F—FINISHING WORK ON BUILDINGS, e.g. STAIRS, FLOORS
- E04F21/00—Implements for finishing work on buildings
- E04F21/02—Implements for finishing work on buildings for applying plasticised masses to surfaces, e.g. plastering walls
- E04F21/04—Patterns or templates; Jointing rulers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Architecture (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Structural Engineering (AREA)
- Civil Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of formula wherein A and D are each H, halo or C 1-7 alkyl B is n-butoxy, dialkylaminoalkoxy, alkylsulphonyloxy, arylsulphonyloxy or nitro and R and R1 are each alkyl or together with the intervening nitrogen atom represent an optionally substituted heterocyclic ring which may have N or O as a further heteroatom and pharmaceutically acceptable salts thereof. Preparation of these compounds is from the corresponding nitriles by reaction with NHRR1, the reaction being conducted either with the latter reactant in the form of a Grignard compound or in the presence of a Lewis acid. Subsequently, salt-formation, salt-hydrolysis or salt-interconversion may be effected as required. Pharmaceutical compositions for oral, parenteral, rectal and topical administration comprise the inventive compounds (to which is ascribed anthelmintic activity) and a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI000764 | 1967-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES361907A1 true ES361907A1 (en) | 1970-11-01 |
Family
ID=10994343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES361907A Expired ES361907A1 (en) | 1967-12-28 | 1968-12-27 | Procedure for preparing new benzamidine substitute heterociclic compounds. (Machine-translation by Google Translate, not legally binding) |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT286962B (en) |
| BE (1) | BE726123A (en) |
| CH (1) | CH523229A (en) |
| CS (1) | CS155819B1 (en) |
| DE (1) | DE1810836A1 (en) |
| ES (1) | ES361907A1 (en) |
| FR (1) | FR8467M (en) |
| GB (1) | GB1257929A (en) |
| IL (1) | IL31159A (en) |
| NL (1) | NL6818462A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2963600D1 (en) * | 1978-04-27 | 1982-10-28 | Laroche Navarron Sa | Piperazine methane imine derivatives, methods for their preparation and their therapeutical use |
-
1968
- 1968-11-25 DE DE19681810836 patent/DE1810836A1/en active Pending
- 1968-11-26 IL IL31159A patent/IL31159A/en unknown
- 1968-11-29 AT AT1161968A patent/AT286962B/en not_active IP Right Cessation
- 1968-12-20 NL NL6818462A patent/NL6818462A/xx unknown
- 1968-12-23 CH CH1916568A patent/CH523229A/en not_active IP Right Cessation
- 1968-12-27 BE BE726123D patent/BE726123A/xx not_active IP Right Cessation
- 1968-12-27 ES ES361907A patent/ES361907A1/en not_active Expired
- 1968-12-28 GB GB1257929D patent/GB1257929A/en not_active Expired
- 1968-12-28 CS CS884768A patent/CS155819B1/cs unknown
-
1969
- 1969-03-18 FR FR183289A patent/FR8467M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL31159A (en) | 1972-08-30 |
| BE726123A (en) | 1969-05-29 |
| FR8467M (en) | 1972-01-07 |
| CH523229A (en) | 1972-05-31 |
| CS155819B1 (en) | 1974-06-24 |
| IL31159A0 (en) | 1969-01-29 |
| NL6818462A (en) | 1969-07-01 |
| DE1810836A1 (en) | 1970-01-08 |
| AT286962B (en) | 1971-01-11 |
| GB1257929A (en) | 1971-12-22 |
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