ES361989A1 - Procedure for the obtaining of derivatives of 7-aminocephaloesporanic acid. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining derivatives of 7-aminocephaloesporanic acid, characterized in that the compounds of formula I: **(See formula)** wherein R1 signifies an imidazolium or imidazolyl radical, optionally hydrogenated, which is bonded with a nitrogen atom to the acetylamino radical and wherein R2 signifies a free hydroxyl radical or esterified by a carboxylic acid, wherein the atoms The oxygen atoms in the ester may be substituted by sulfur atoms, a carbamoyloxy radical, optionally N-substituted, in which the oxygen atoms may be substituted by sulfur or a quaternary ammonium radical, and optionally its internal salts yes a compound of formula II: **(See formula)** wherein Z signifies a haloacetyl moiety and R2 has the meaning of above, is reacted with an imidazole, optionally hydrogenated, or a compound of formula II where Z signifies hydrogen, is acylated with the radical R1-CH2 -CO-, in which R1 represents an imidazolyl radical, optionally hydrogenated and, if desired, the compounds obtained with a hydroxy radical R2 free or esterified by a carboxylic acid transform each other and, if desired, into the compounds obtained in which R2 signifies a hydroxyl radical esterified by a carboxylic acid, in which the oxygen atoms may be substituted by sulfur atoms, these radicals are substituted in a manner known per se by a carbamoyloxy radical, if appropriate, N-substituted, in which the oxygen atoms can be substituted by sulfur or by a quaternary ammonium radical and, if desired, optionally, the obtained compounds are transformed into their metal salts, such as alkaline or alkali inoterreas or salts with ammonia or organic bases, or from the salts obtained free carboxylic acids are formed or, if necessary, internal salts. (Machine-translation by Google Translate, not legally binding)