ES363295A1 - A procedure for preparing benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for preparing benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES363295A1 ES363295A1 ES363295A ES363295A ES363295A1 ES 363295 A1 ES363295 A1 ES 363295A1 ES 363295 A ES363295 A ES 363295A ES 363295 A ES363295 A ES 363295A ES 363295 A1 ES363295 A1 ES 363295A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- machine
- legally binding
- google translate
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for preparing benzodiazepine derivatives, characterized by cyclizing a compound of the general formula **(See formula)** where X represents a carbonyl or methylene group; R1 represents hydrogen or lower alkyl; represents hydrogen, halogen lower alkyl, lower alkoxy or trifluoromethyl; R3 and R4 are the same or different and each represent hydrogen, lower alkyl, halogen, lower alkoxy, trifluoromethyl, nitro, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl; and R5 and R6 represents hydrogen, lower alkyl, acyl, aryl, or lower aralkyl, or a respective halohydric salt, under acidic conditions, to produce a 5-phenyl-3H-l, 4-benzodiazepine derivative of the general formula **(See formula)** where X, R1, R2, R3 and R4 have the same meaning as indicated above. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP688468A JPS5130074B1 (en) | 1968-02-06 | 1968-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES363295A1 true ES363295A1 (en) | 1970-12-16 |
Family
ID=11650643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES363295A Expired ES363295A1 (en) | 1968-02-06 | 1969-02-05 | A procedure for preparing benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5130074B1 (en) |
| BR (1) | BR6906070D0 (en) |
| CH (1) | CH513886A (en) |
| DK (1) | DK136423C (en) |
| ES (1) | ES363295A1 (en) |
| SE (1) | SE372532B (en) |
| YU (1) | YU33789B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2132708B1 (en) * | 1971-04-08 | 1976-04-16 | Chugai Pharmaceutical Co Ltd |
-
1968
- 1968-02-06 JP JP688468A patent/JPS5130074B1/ja active Pending
-
1969
- 1969-01-23 CH CH115269A patent/CH513886A/en not_active IP Right Cessation
- 1969-01-28 SE SE112569A patent/SE372532B/xx unknown
- 1969-02-03 BR BR20607069A patent/BR6906070D0/en unknown
- 1969-02-04 DK DK60369A patent/DK136423C/en not_active IP Right Cessation
- 1969-02-05 ES ES363295A patent/ES363295A1/en not_active Expired
- 1969-02-06 YU YU27169A patent/YU33789B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5130074B1 (en) | 1976-08-30 |
| BR6906070D0 (en) | 1973-03-13 |
| CH513886A (en) | 1971-10-15 |
| YU33789B (en) | 1978-05-15 |
| DK136423B (en) | 1977-10-10 |
| YU27169A (en) | 1977-10-31 |
| SE372532B (en) | 1974-12-23 |
| DK136423C (en) | 1978-03-13 |
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