ES364004A1 - Procedimiento para la preparacion de derivados del estra- diol. - Google Patents

Procedimiento para la preparacion de derivados del estra- diol.

Info

Publication number: ES364004A1
Authority: ES; Spain
Prior art keywords: compounds; alkali metal; alkyl; prepared; tetrahydropyran
Prior art date: 1968-02-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES364004A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-02-26

Filing date

1969-02-24

Publication date

1971-02-16

1969-02-24 Application filed by Sandoz AG filed Critical Sandoz AG

1971-02-16 Publication of ES364004A1 publication Critical patent/ES364004A1/es

Status Expired legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 abstract 14
229910052783 alkali metal Inorganic materials 0.000 abstract 6
150000001340 alkali metals Chemical class 0.000 abstract 6
239000011777 magnesium Substances 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
238000006243 chemical reaction Methods 0.000 abstract 3
125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 3
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical group [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
-1 carboxyethynyl Chemical group 0.000 abstract 1
239000000969 carrier Substances 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
150000002162 estranes Chemical class 0.000 abstract 1
230000001076 estrogenic effect Effects 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229910052749 magnesium Chemical group 0.000 abstract 1
230000016087 ovulation Effects 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001072 progestational effect Effects 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

ES364004A 1968-02-26 1969-02-24 Procedimiento para la preparacion de derivados del estra- diol. Expired ES364004A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70799168A	1968-02-26	1968-02-26
US73733968A	1968-06-17	1968-06-17

Publications (1)

Publication Number	Publication Date
ES364004A1 true ES364004A1 (es)	1971-02-16

Family

ID=27107998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES364004A Expired ES364004A1 (es)	1968-02-26	1969-02-24	Procedimiento para la preparacion de derivados del estra- diol.

Country Status (7)

Country	Link
BE (1)	BE728870A (de)
CH (1)	CH515228A (de)
DE (1)	DE1909089A1 (de)
ES (1)	ES364004A1 (de)
FR (1)	FR2002599A1 (de)
GB (1)	GB1260392A (de)
SE (1)	SE350490B (de)

1969
- 1969-02-12 CH CH208769A patent/CH515228A/de not_active IP Right Cessation
- 1969-02-14 GB GB8113/69A patent/GB1260392A/en not_active Expired
- 1969-02-19 SE SE02282/69A patent/SE350490B/xx unknown
- 1969-02-24 BE BE728870D patent/BE728870A/xx unknown
- 1969-02-24 ES ES364004A patent/ES364004A1/es not_active Expired
- 1969-02-24 DE DE19691909089 patent/DE1909089A1/de active Pending
- 1969-02-24 FR FR6904639A patent/FR2002599A1/fr not_active Withdrawn

Also Published As

Publication number	Publication date
DE1909089A1 (de)	1969-09-11
CH515228A (de)	1971-11-15
GB1260392A (en)	1972-01-19
BE728870A (de)	1969-08-25
FR2002599A1 (de)	1969-10-31
SE350490B (de)	1972-10-30

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