ES364636A1 - Procedure for the preparation of new derivatives of 5h-dibenz (b, f) azepine. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new derivatives of 5h-dibenz (b, f) azepine. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES364636A1 ES364636A1 ES364636A ES364636A ES364636A1 ES 364636 A1 ES364636 A1 ES 364636A1 ES 364636 A ES364636 A ES 364636A ES 364636 A ES364636 A ES 364636A ES 364636 A1 ES364636 A1 ES 364636A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- general formula
- organic
- carbon atoms
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LCGTWRLJTMHIQZ-UHFFFAOYSA-N 5H-dibenzo[b,f]azepine Chemical class C1=CC2=CC=CC=C2NC2=CC=CC=C21 LCGTWRLJTMHIQZ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 239000002609 medium Substances 0.000 abstract 2
- 150000002763 monocarboxylic acids Chemical class 0.000 abstract 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- TUCNEACPLKLKNU-UHFFFAOYSA-N acetyl Chemical compound C[C]=O TUCNEACPLKLKNU-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Process for the preparation of new 5h-dibenz [b, f] azepine derivatives of the general formula i ** (see formula) ** In which R1 means hydrogen or a lower alkyl group with at most 3 carbon atoms, R2 means hydrogen or a lower alkyl group with at most 4 carbon atoms, R3 signifies hydrogen or chlorine, as well as the salts of the carboxylic acids falling under the general formula i, characterized in that a compound of the general formula ii ** (see formula) ** In which R1 means an alkyl group with at most 3 carbon atoms; A1 means a lower alkoxycarbonyl group (-co-o-alkyl) or the cyano group and a2 means a lower alkoxycarbonyl group, a lower alkoxyalkyl group (-co-co-o-alkyl), the cyano group or the acetyl group and r2 and r3 have the significance indicated under formula i, It is allowed to react in an organic or aqueous-organic medium with an alkaline hydroxide or, if neither a, nor a2 is a cyano group, in water-free medium also with an alkaline alkanolate or, in case a2 is not a acetyl radical, in organic-aqueous medium also with a mineral acid, of the alkali salt of a dicarboxylic acid optionally obtained first in the use of an alkaline hydroxide the acid is released and heated until splitting of the equimolar dose of carbon dioxide and eventually carbon monoxide, and if desired a free monocarboxylic acid obtained is transformed into a salt with an inorganic or organic base or a salt obtained from a monocarboxylic acid of the general formula i the latter is released. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH215969A CH506529A (en) | 1969-02-14 | 1969-02-14 | Dibenzazepinylacetic acid derivs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES364636A1 true ES364636A1 (en) | 1971-06-16 |
Family
ID=4227254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES364636A Expired ES364636A1 (en) | 1969-02-14 | 1969-02-28 | Procedure for the preparation of new derivatives of 5h-dibenz (b, f) azepine. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH506529A (en) |
| ES (1) | ES364636A1 (en) |
-
1969
- 1969-02-14 CH CH215969A patent/CH506529A/en not_active IP Right Cessation
- 1969-02-28 ES ES364636A patent/ES364636A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH506529A (en) | 1971-04-30 |
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