ES365404A1 - Procedimiento para la preparacion de eteres de la 1-alfa, 2alfa-metilen-19-nortestorterona y sus homologos de 18-alco- hilo. - Google Patents

Procedimiento para la preparacion de eteres de la 1-alfa, 2alfa-metilen-19-nortestorterona y sus homologos de 18-alco- hilo.

Info

Publication number: ES365404A1
Authority: ES; Spain
Prior art keywords: alpha; methyl; estran; methylene; prepared
Prior art date: 1968-04-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES365404A

Other languages

English (en)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-04-05

Filing date

1969-03-28

Publication date

1971-01-01

1969-03-28 Application filed by Schering AG filed Critical Schering AG

1971-01-01 Publication of ES365404A1 publication Critical patent/ES365404A1/es

Status Expired legal-status Critical Current

Links

229960004719 nandrolone Drugs 0.000 title 1
150000003431 steroids Chemical class 0.000 abstract 3
PVFOHMXILQEIHX-UHFFFAOYSA-N 8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9-[2-(2-bromophenyl)ethyl]purin-6-amine Chemical compound C=1C=2OCOC=2C=C(Br)C=1SC1=NC=2C(N)=NC=NC=2N1CCC1=CC=CC=C1Br PVFOHMXILQEIHX-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
QENZOBLYOJSARN-GSNZFIHSSA-N (8r,9r,10s,13s,14s)-13-methyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1CC2CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 QENZOBLYOJSARN-GSNZFIHSSA-N 0.000 abstract 1
BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 abstract 1
238000006640 acetylation reaction Methods 0.000 abstract 1
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
229940124325 anabolic agent Drugs 0.000 abstract 1
239000003263 anabolic agent Substances 0.000 abstract 1
230000031709 bromination Effects 0.000 abstract 1
238000005893 bromination reaction Methods 0.000 abstract 1
239000000969 carrier Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000006704 dehydrohalogenation reaction Methods 0.000 abstract 1
230000026030 halogenation Effects 0.000 abstract 1
238000005658 halogenation reaction Methods 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000011987 methylation Effects 0.000 abstract 1
238000007069 methylation reaction Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ES365404A 1968-04-05 1969-03-28 Procedimiento para la preparacion de eteres de la 1-alfa, 2alfa-metilen-19-nortestorterona y sus homologos de 18-alco- hilo. Expired ES365404A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19681768161 DE1768161B2 (de)	1968-04-05	1968-04-05	Aether des 1 alpha, 2 alpha-methylen-19-nor-testosterons und seiner 18- alkylhomologen, verfahren zu ihrer herstellung, diese enthaltende arzneimittel sowie entsprechende 5 alpha-oestran-zwischenprodukte

Publications (1)

Publication Number	Publication Date
ES365404A1 true ES365404A1 (es)	1971-01-01

Family

ID=5699619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES365404A Expired ES365404A1 (es)	1968-04-05	1969-03-28	Procedimiento para la preparacion de eteres de la 1-alfa, 2alfa-metilen-19-nortestorterona y sus homologos de 18-alco- hilo.

Country Status (16)

Country	Link
US (1)	US3590033A (es)
AT (2)	AT290743B (es)
BE (1)	BE731081A (es)
CH (1)	CH535219A (es)
CS (3)	CS162679B2 (es)
DE (1)	DE1768161B2 (es)
DK (1)	DK119109B (es)
ES (1)	ES365404A1 (es)
FI (1)	FI45320C (es)
FR (1)	FR2007402A1 (es)
GB (1)	GB1265393A (es)
IE (1)	IE32768B1 (es)
IL (1)	IL31926A (es)
NL (1)	NL160571C (es)
NO (1)	NO129348B (es)
SE (1)	SE344063B (es)

1968
- 1968-04-05 DE DE19681768161 patent/DE1768161B2/de active Granted
1969
- 1969-03-11 CH CH366869A patent/CH535219A/de not_active IP Right Cessation
- 1969-03-17 DK DK143669AA patent/DK119109B/da unknown
- 1969-03-21 AT AT282269A patent/AT290743B/de not_active IP Right Cessation
- 1969-03-21 AT AT922969A patent/AT289308B/de not_active IP Right Cessation
- 1969-03-24 CS CS741409A patent/CS162679B2/cs unknown
- 1969-03-24 CS CS741410A patent/CS162680B2/cs unknown
- 1969-03-24 CS CS2074A patent/CS162678B2/cs unknown
- 1969-03-28 ES ES365404A patent/ES365404A1/es not_active Expired
- 1969-03-30 IL IL31926A patent/IL31926A/en unknown
- 1969-03-31 GB GB1265393D patent/GB1265393A/en not_active Expired
- 1969-03-31 SE SE4540/69A patent/SE344063B/xx unknown
- 1969-04-01 IE IE443/69A patent/IE32768B1/xx unknown
- 1969-04-01 FI FI690958A patent/FI45320C/fi active
- 1969-04-01 NO NO01365/69A patent/NO129348B/no unknown
- 1969-04-03 NL NL6905323.A patent/NL160571C/xx not_active IP Right Cessation
- 1969-04-04 BE BE731081D patent/BE731081A/xx unknown
- 1969-04-04 FR FR6910486A patent/FR2007402A1/fr not_active Withdrawn
- 1969-04-04 US US815259A patent/US3590033A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE32768L (en)	1969-10-05
SE344063B (es)	1972-03-27
NL160571B (nl)	1979-06-15
AT290743B (de)	1971-06-11
AT289308B (de)	1971-04-13
DE1768161B2 (de)	1977-06-23
CH535219A (de)	1973-03-31
NL6905323A (es)	1969-10-07
BE731081A (es)	1969-10-06
FI45320C (fi)	1972-05-10
CS162679B2 (en)	1975-07-15
FR2007402A1 (es)	1970-01-09
DK119109B (da)	1970-11-16
DE1768161A1 (de)	1971-11-18
US3590033A (en)	1971-06-29
NO129348B (es)	1974-04-01
NL160571C (nl)	1979-11-15
FI45320B (es)	1972-01-31
IL31926A0 (en)	1969-05-28
IL31926A (en)	1973-06-29
IE32768B1 (en)	1973-11-28
GB1265393A (es)	1972-03-01
CS162678B2 (es)	1975-07-15
CS162680B2 (en)	1975-07-15

Publication	Publication Date	Title
GB1087316A (en)	1967-10-18	7ª-methyl-oestratrienes
GB1265393A (es)	1972-03-01
GB1206874A (en)	1970-09-30	7alpha-METHYL-6&beta,19-OXIDO-ANDROSTANE COMPOUNDS
US3290297A (en)	1966-12-06	Tetrahydrofuranyl ethers of delta1, 3, 5(10)-estratriene
GB1085035A (en)	1967-09-27	New 3,3-methylene-19-nor-steroids
GB1014890A (en)	1965-12-31	Steroid 17ª-yi acetals and process for their preparation
GB1317194A (en)	1973-05-16	21,21-dichloro-steroids
GB996079A (en)	1965-06-23	17ª‡,21-substituted methylenedioxy steroids and methods therefor
GB1289852A (es)	1972-09-20
GB1311725A (en)	1973-03-28	18-cyano pregnane compounds and process for their manufacture
GB1286097A (en)	1972-08-16	2-HALOGENO-18-METHYL-Delta<1>-ANDROSTENES
GB1094806A (en)	1967-12-13	Unsaturated steroid compounds and processes for their preparation
ES343908A2 (es)	1968-10-01	Un procedimiento para preparar dihalometilen esteroides.
GB1051580A (es)
GB1162769A (en)	1969-08-27	Delta<,5>-7alpha-Methyl-Estradienes and their preparation
ES362790A1 (es)	1971-02-16	Un procedimiento para preparar un 3-ciclopentiloxi -este- roide.
GB965292A (en)	1964-07-29	Halogenated steroid derivatives
GB1235642A (en)	1971-06-16	A new oestratriol and a process for its manufacture
GB1336434A (en)	1973-11-07	14,18- epoxy-ethanoimino steroids their preparation and compositions containing them
GB1208884A (en)	1970-10-14	Tetrahydropyranylethers of steroids and process for their manufacture
GB1377993A (en)	1974-12-18	6alpha, 16alpha-dimethyl-steroids
FR2438055A1 (fr)	1980-04-30	Nouveaux homo-nor-steroides et leurs methodes de preparation
GB1095722A (en)	1967-12-20	Improvements in or relating to 10ª-methyl steroid compounds
GB1085913A (en)	1967-10-04	Improvements in or relating to pharmacologically-active compounds being 9ª10ªmethyl steroids
US3028401A (en)	1962-04-03	6-fluoro-19-nor-testosterone derivatives