ES367906A1 - Procedure for the obtaining of polyhydroxypenyl-stabilizing creams of the cellular structure and the cytometabolism (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of polyhydroxypenyl-stabilizing creams of the cellular structure and the cytometabolism (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES367906A1 ES367906A1 ES367906A ES367906A ES367906A1 ES 367906 A1 ES367906 A1 ES 367906A1 ES 367906 A ES367906 A ES 367906A ES 367906 A ES367906 A ES 367906A ES 367906 A1 ES367906 A1 ES 367906A1
- Authority
- ES
- Spain
- Prior art keywords
- solvent system
- cytometabolism
- stabilizing
- translation
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 210000003850 cellular structure Anatomy 0.000 title 1
- 239000006071 cream Substances 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 244000272459 Silybum marianum Species 0.000 abstract 1
- 235000010841 Silybum marianum Nutrition 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 235000011869 dried fruits Nutrition 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/40—Separation, e.g. from natural material; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Process for obtaining polyhydroxyphenylchromones stabilizing the cell structure and cytometabolism, characterized by tearing, in the cellular complex, by means of great mechanical pressure, preferably in a helical press, dried fruits of silybum marianum gaertn., to exonerate them from the main quantity of the oil fatty; extracting thoroughly with ethyl acetate the press residue still having a residual oil content of 5 to 10%; evaporate the ethyl acetate; dissolve in 2% by weight, in the lower phase of a solvent system suitable for the separation of the undesired concomitant substances, for example the solvent system constituted essentially by methanol and petroleum ether, the dry, oily-crass residue and partially lumpy, containing about 20 to 30% active matter; centrifuge to clarify and remove the flocculent particles of solid matter; the residue in said solvent system is subjected to the multiplicative, preferably uniform, countercurrent distribution; a brownish powder containing 70 to 80% polyhydroxyphenylchromones is separated from the lower leaving phase by concentration in vacuo; and optionally, the silymarin i, which during the concentration is segregated in the form of a white to ocher crystallized, is already directly separated from the lower phase. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1923082A DE1923082C3 (en) | 1969-05-06 | 1969-05-06 | Process for the production of polyhydroxyphenylchromanones (Silymarin I-IV) and medicaments containing the polyhydroxyphenylchromanone (Silymarin I-IV = Silymarin I-IV group) mixture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES367906A1 true ES367906A1 (en) | 1971-04-16 |
Family
ID=5733385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES367906A Expired ES367906A1 (en) | 1969-05-06 | 1969-05-31 | Procedure for the obtaining of polyhydroxypenyl-stabilizing creams of the cellular structure and the cytometabolism (Machine-translation by Google Translate, not legally binding) |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT290723B (en) |
| CH (1) | CH541554A (en) |
| CS (1) | CS162722B2 (en) |
| DE (1) | DE1923082C3 (en) |
| ES (1) | ES367906A1 (en) |
| FI (1) | FI50932C (en) |
| IE (1) | IE34110B1 (en) |
| IL (1) | IL34381A (en) |
| NO (1) | NO130345B (en) |
| PL (1) | PL80560B1 (en) |
| YU (1) | YU37065B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2428680C2 (en) * | 1974-06-14 | 1983-02-17 | Dr. Madaus & Co, 5000 Köln | 1- (2 ', 4', 6'-trihydroxyphenyl) propanedione (1,2) compounds, processes for their preparation and pharmaceuticals containing these compounds |
| DE3537656A1 (en) * | 1984-11-22 | 1986-05-22 | Dr. Madaus GmbH & Co, 5000 Köln | METHOD FOR PRODUCING ISOSILYBIN-FREE SILIBININE AND MEDICINAL PRODUCTS CONTAINING SILIBININE |
| FR2594691B1 (en) * | 1986-02-24 | 1990-08-03 | Bonne Claude | NEW COSMETIC PREPARATIONS CONTAINING EXTRACT OF SILYBUM MARIANUM FRUITS |
| DE4401902C2 (en) * | 1994-01-24 | 2000-02-03 | Madaus Ag | Use of flavolignans as an adjuvant in tumor therapy |
| EP2959910A1 (en) | 2014-06-26 | 2015-12-30 | Bionorica Se | Milk thistle extract of fruit shells of Silybum marianum, process of manufacture and use |
| EP4696313A1 (en) | 2024-08-13 | 2026-02-18 | WÖRWAG Pharma GmbH & Co.KG | Formulation of krill oil and silymarin |
-
1969
- 1969-05-06 DE DE1923082A patent/DE1923082C3/en not_active Expired
- 1969-05-30 AT AT517269A patent/AT290723B/en not_active IP Right Cessation
- 1969-05-30 CH CH825169A patent/CH541554A/en not_active IP Right Cessation
- 1969-05-31 ES ES367906A patent/ES367906A1/en not_active Expired
-
1970
- 1970-04-21 IE IE510/70A patent/IE34110B1/en unknown
- 1970-04-24 IL IL34381A patent/IL34381A/en unknown
- 1970-05-04 YU YU1129/70A patent/YU37065B/en unknown
- 1970-05-05 CS CS3099A patent/CS162722B2/cs unknown
- 1970-05-05 PL PL1970140431A patent/PL80560B1/pl unknown
- 1970-05-05 NO NO01710/70A patent/NO130345B/no unknown
- 1970-05-05 FI FI701253A patent/FI50932C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| FI50932C (en) | 1976-09-10 |
| CH541554A (en) | 1973-09-15 |
| FI50932B (en) | 1976-05-31 |
| PL80560B1 (en) | 1975-08-30 |
| NO130345B (en) | 1974-08-19 |
| IL34381A (en) | 1973-06-29 |
| CS162722B2 (en) | 1975-07-15 |
| DE1923082A1 (en) | 1970-11-19 |
| AT290723B (en) | 1971-06-11 |
| IE34110L (en) | 1970-11-06 |
| YU37065B (en) | 1984-08-31 |
| YU112970A (en) | 1983-04-27 |
| IE34110B1 (en) | 1975-02-05 |
| DE1923082C3 (en) | 1985-08-22 |
| DE1923082B2 (en) | 1974-09-19 |
| IL34381A0 (en) | 1970-06-17 |
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